Sex Difference Between Trace Elements and Pulmonary Functions in Children

Pan, Zhenzhen; Zhang, Xiaojuan; Yu, Hui; Xiang, Hongxia; Wang, Qian; Xu, Shiyao; Li, Ling

doi:10.1007/s12011-019-02019-4

Cited by 4 publications

(4 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Se deficiency is a common micronutrient deficiency, impacting 500 million to 1 billion individuals globally [ 11 ]. Low circulating Se levels have been associated with poor respiratory health in infants and children, including an increased incidence of childhood wheeze [ 12 ], pediatric asthma [ 12 , 13 , 14 ], worse pulmonary function in school-aged children [ 15 ], and prolonged ventilatory courses in inflamed pediatric patients [ 16 ]. Clinical evidence indicates that lung development can be impaired early after birth when a baby is Se deficient.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development

et al. 2022

View full text Add to dashboard Cite

Decreased selenium (Se) levels during childhood and infancy are associated with worse respiratory health. Se is biologically active after incorporation into Se-containing antioxidant enzymes (AOE) and proteins. It is unknown how decreased maternal Se during pregnancy and lactation impacts neonatal pulmonary selenoproteins, growth, and lung development. Using a model of neonatal Se deficiency that limits Se intake to the dam during pregnancy and lactation, we evaluated which neonatal pulmonary selenoproteins are decreased in both the saccular (postnatal day 0, P0) and early alveolar (postnatal day 7, P7) stages of lung development. We found that Se deficient (SeD) pups weigh less and exhibit impaired alveolar development compared to Se sufficient (SeS) pups at P7. The activity levels of glutathione peroxidase (GPx) and thioredoxin reductase (Txnrd) were decreased at P0 and P7 in SeD lungs compared to SeS lungs. Protein content of GPx1, GPx3 and Txnrd1 were decreased in SeD lungs at P0 and P7, whereas Txnrd2 content was unaltered compared to SeS controls. The expression of NRF-2 dependent genes and several non-Se containing AOE were similar between SeS and SeD lungs. SeD lungs exhibited a decrease in selenoprotein N, an endoplasmic reticulum protein implicated in alveolar development, at both time points. We conclude that exposure to Se deficiency during pregnancy and lactation impairs weight gain and lung growth in offspring. Our data identify multiple selenoproteins in the neonatal lung that are vulnerable to decreased Se intake, which may impact oxidative stress and cell signaling under physiologic conditions as well as after oxidative stressors.

show abstract

Section: Introductionmentioning

confidence: 99%

Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development

et al. 2022

View full text Add to dashboard Cite

show abstract

“…A more plausible explanation might be that these sex‐related differences are due to a dysanaptic growth of airways and lungs in boys, with a slower growth of the larger airways than lung volume (Pagtakhan et al., 1984 ). Finally, it has been described small but statistically significant differences between boys and girls regarding blood concentrations of trace elements such as Zn, Fe, and Cu (Cao et al., 2016 ), and at least for Zn a positive association with lung function (FVC and FEV 1 ) has been reported (Pan et al., 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study

Gochicoa‐Rangel,

Chávez,

Del‐Río‐Hidalgo

et al. 2023

Physiological Reports

View full text Add to dashboard Cite

Pulmonary mechanics has been traditionally viewed as determined by lung size and physical factors such as frictional forces and tissue viscoelastic properties, but few information exists regarding potential influences of cytokines and hormones on lung function. Concentrations of 28 cytokines and hormones were measured in saliva from clinically healthy scholar children, purposely selected to include a wide range of body mass index (BMI). Lung function was assessed by impulse oscillometry, spirometry, and diffusing capacity for carbon monoxide, and expressed as z‐score or percent predicted. Ninety‐six scholar children (55.2% female) were enrolled. Bivariate analysis showed that almost all lung function variables correlated with one or more cytokine or hormone, mainly in boys, but only some of them remained statistically significant in the multiple regression analyses. Thus, after adjusting by height, age, and BMI, salivary concentrations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in boys were associated with zR5‐R20 and reactance parameters (zX20, zFres, and zAX), while glucagon inversely correlated with resistances (zR5 and zR20). Thus, in physiological conditions, part of the mechanics of breathing might be influenced by some cytokines and hormones, including glucagon and GM‐CSF. This endogenous influence is a novel concept that warrants in‐depth characterization.

show abstract

“…However, there were no associations between serum Cu and TG levels among children and adolescents in the NHANES 2011–2014 study [ 6 ]. One hypothesis suggests that a key mechanism leading to MetS involves OS caused by redox imbalance [ 63 ]. Thus, Cu and Zn may be related to the development of MetS.…”

Section: Discussionmentioning

confidence: 99%

Copper/Zinc Ratio in Childhood and Adolescence: A Review

et al. 2023

View full text Add to dashboard Cite

Both copper (Cu) and zinc (Zn) are crucial micronutrients for human growth and development. This literature review covered the last five years of available evidence on the Cu/Zn ratio in children and adolescents. We searched PubMed, Web of Science, Google Scholar, Cochrane Library, and Science Direct for publications between 2017 and 2022, especially in English, although publications in other languages with abstracts in English were included. The main terms used were “copper”, “zinc”, “copper-zinc”, and “zinc-copper” ratios. Cu and Zn determinations made in blood, plasma, or serum were included. This review comprises several cross-sectional and case–control studies with substantial results. The bibliographic search generated a compilation of 19 articles, in which 63.2% of the studies mostly reported a significantly higher Cu/Zn ratio, and 57.9% of them informed significantly lower levels of Zn. We conclude that children and adolescents with acute and chronic conditions are at greater risk of developing elevated Cu/Zn ratios, related to altered nutritional, infectious, and inflammatory status.

show abstract

Sex Difference Between Trace Elements and Pulmonary Functions in Children

Cited by 4 publications

References 30 publications

Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development

Neonatal Selenium Deficiency Decreases Selenoproteins in the Lung and Impairs Pulmonary Alveolar Development

Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study

Copper/Zinc Ratio in Childhood and Adolescence: A Review

Contact Info

Product

Resources

About