Background . Age estimation using orthopantomographs (OPGs) has been in practice for a long time, but none of the methods is considered universally accepted yet. Very few studies have been conducted using radiomorphometric indices for age estimation. This study was conducted to assess the radiomorphometric indices using digital OPGs and their applicability for age estimation of individuals in south Indian population. Materials and Methods . OPGs of 611 individuals ( 302 male and 309 females) were selected on basis of predetermined inclusion and exclusion criteria. The OPGs of the patients ( age 0 to 69 years) were divided into 7 groups ( each decade) . The 6 radiomorphometric indices of bilateral Mandible ( upper and lower Ramus breadth; condylar , projected and coronoid ramus height ; and gonial angle ) were measured on Monitor of 15" display LED Screen using IMAGE J software.Results. The mean gonial angle was found to be higher in females as compared to males in all the age groups (with maximum in 10-19years age groups ) except in 03-09years age groups. In contrast to that, mean condylar height , mean projected condylar height , mean coronoid ramus height, and mean ramus breadth were found to be higher in males as compared to females in all the age groups except in 03-09 years groups, which was statically significant. Gonial angle was found to be greater in 3 to 19years age group, and thereafter decreasing with age. Condylar height , projective condylar height and coronoid ramus height were found to be increasing during 2 nd and 3 rd decades i.e 19 to 39 age group and thereafter decreasing with age (positive correlation ). Conclusion . Condylar height was found to be the most significant age predictor and ramus breadth was found to be most insignificant age predictor.