Sex-dependent relationship between n -3 long-chain polyunsaturated fatty acids and insulin resistance: A systematic review

Abbott, Kylie; Thota, Rohith N.; Burrows, T.; Acharya, Shamasunder; Garg, Manohar L.

doi:10.1016/j.jnim.2015.12.182

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 A clinical study reported that supplementation with DHA-rich fish oil increased testosterone levels in overweight and obese men, which suggested that DHA might promote Leydig cell function. 10 The phospholipid content of the rodent testis plasma membrane could be altered by changes in the dietary fat composition, and DHA could influence the regulation of gonadotropin receptor-mediated activity in testis. 11 Dietary n-3 PUFAs are essential for the functional maturation of the brain and peripheral tissue, and low maternal consumption of n-3 PUFAs has been associated with neurodevelopmental disorders in offspring.…”

Section: ■ Introductionmentioning

confidence: 99%

N-3 PUFA Deficiency from Early Life to Adulthood Exacerbated Susceptibility to Reactive Oxygen Species-Induced Testicular Dysfunction in Adult Mice

Zhao

Wang

Yang

et al. 2023

J. Agric. Food Chem.

View full text Add to dashboard Cite

Homeostasis of reactive oxygen species is required to maintain sperm maturation and capacitation. Docosahexaenoic acid (DHA) is accumulated in testicles and spermatozoa and has the ability to manipulate the redox status. The effects of dietary n-3 polyunsaturated fatty acid (n-3 PUFA) deficiency from early life to adulthood on the physiological and functional properties of males under the redox imbalance of testicular tissue deserve attention. The consecutive injection of hydrogen peroxide (H 2 O 2 ) and tertbutyl hydroperoxide (t-BHP) for 15 days to induce oxidative stress in testicular tissue was used to elucidate the consequences of testicular n-3 PUFA deficiency. The results indicated that reactive oxygen species treatment in adult male mice with DHA deficiency in the testis could reduce spermatogenesis and disrupt sex hormone production, as well as trigger testicular lipid peroxidation and tissue damage. N-3 PUFA deficiency from early life to adulthood resulted in higher susceptibility to testicular dysfunction in the germinal function of supplying germ cells and the endocrine role of secreting hormones through the mechanism of aggravating mitochondria-mediated apoptosis and destruction of blood testicular barrier under oxidative stress, which might provide a basis for humans to reduce susceptibility to chronic disease and maintain reproductive health in adulthood through dietary interventions of n-3 PUFAs.

show abstract

Section: ■ Introductionmentioning

confidence: 99%