Abstract:Rodent premotor cortex (M2) integrates information from sensory and cognitive networks for action selection and planning during goal-directed decision making. M2 function is regulated by cortical inputs and ascending neuromodulators, including norepinephrine (NE) released from the locus coeruleus (LC). LC-NE has been shown to modulate the signal to noise ratio of neural representations in target regions prior to decision execution, to increase the salience of relevant stimuli. Using rats performing a two-alter… Show more
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