Sex‐dependent effects of uric acid on cerebral microbleed: a cross‐sectional study in the general population

Jeong, Su Jin; Yoo, Taiwoo; Nam, You Seon; Kim, S. H.; Lee, J. E.; Lim, Jae Sung; Kwon, Hyung‐Min; Park, J.‐H.

doi:10.1111/ene.13378

Cited by 10 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This also may reflex the dual effect of UA. In a cross-sectional study of 2,686 patients, Jeong et al reported that a high UA level was a risk factor for cerebral microbleeds only in male patients (19), and we confirmed and extended this finding in our study. Further studies are needed to explore whether these patients are potential candidates for interventions.…”

Section: Discussionsupporting

confidence: 90%

“…UA levels are commonly available in medical settings, and the results of our study suggested that UA may be a potential target for interventions. Several previous studies have investigated the sex differences of UA in patients with cerebrovascular diseases (19,20). Recently, a similar study reported that the incidence of spontaneous HT was higher in patients with low UA levels than in patients with high UA levels (13).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Sex-dependent association analysis between serum uric acid and spontaneous hemorrhagic transformation in patients with ischemic stroke

et al. 2023

View full text Add to dashboard Cite

ObjectiveThe association between serum uric acid (UA) and spontaneous hemorrhagic transformation (HT) has been seldom studied, and the role of UA in spontaneous HT remains unclear. This study aims to investigate the sex-dependent association between UA and spontaneous HT in patients with ischemic stroke.MethodWe retrospectively included patients with ischemic stroke in a tertiary academic hospital between December 2016 and May 2020. Patients were included if they presented within 24 h after the onset of symptoms and did not receive reperfusion therapy. Spontaneous HT was determined by an independent evaluation of neuroimaging by three trained neurologists who were blinded to clinical data. A univariate analysis was performed to identify factors related to spontaneous HT. Four logistic regression models were established to adjust each factor and assess the association between UA and spontaneous HT.ResultsA total of 769 patients were enrolled (64.6% were male patients and 3.9% had HT). After adjusting the confounders with a P < 0.05 (model A) in the univariate analysis, the ratio of UA and its interquartile range (RUI) was independently associated with spontaneous HT in male patients (OR: 1.85; 95% CI: 1.07–3.19; P = 0.028), but not in female patients (OR: 1.39; 95% CI: 0.28–6.82; P = 0.685). In models B–D, the results remain consistent with model A after the adjustment for other potential confounders.ConclusionsHigher serum UA was independently associated with a higher occurrence of spontaneous HT in male patients who were admitted within 24 h after the stroke onset without receiving reperfusion therapy.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Sex-dependent association analysis between serum uric acid and spontaneous hemorrhagic transformation in patients with ischemic stroke

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Stroke remains the most common problem for neurologists to diagnose and treat . Preventative measures, such as control of hypertension, reduction in smoking and treatment of hyperlipidaemia, have made a significant contribution to preventing and delaying stroke onset.…”

mentioning

confidence: 99%

Progress in neurology 2017–2018

Schapira

2018

Euro J of Neurology

View full text Add to dashboard Cite

Lower uric acid level may be associated with hemorrhagic transformation after intravenous thrombolysis

et al. 2021

View full text Add to dashboard Cite

Sex‐dependent effects of uric acid on cerebral microbleed: a cross‐sectional study in the general population

Abstract: High serum UA value was associated with higher prevalence of CMB in male, but lower prevalence of CMB in female subjects.

Cited by 10 publications

References 26 publications

Sex-dependent association analysis between serum uric acid and spontaneous hemorrhagic transformation in patients with ischemic stroke

Sex-dependent association analysis between serum uric acid and spontaneous hemorrhagic transformation in patients with ischemic stroke

Progress in neurology 2017–2018

Lower uric acid level may be associated with hemorrhagic transformation after intravenous thrombolysis

Contact Info

Product

Resources

About