Sex‐Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice

Leung, Lana; Martin, Joshua; Lawmaster, Todd; Arthur, Kathryn A.; Al‐Nakkash, Layla

doi:10.1155/2016/1796357

Cited by 3 publications

(3 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar values in healthy and MetS + Sd + SAE and MetS + HFd + SAE group suggest that Aronia extract was capable of improving fractional shortening during both high-calorie and standard dietary conditions in the presence of metabolic syndrome. In accordance with our findings, it has been previously reported that polyphenolics and plants rich in polyphenolics had effect in lessening the pathological alterations in FS promoted by MetS [27,28,29]. A decrease in systemic blood pressure after Aronia extract treatment may increase fractional shortenings, resulting in increased myocardial contractility [30].…”

Section: Discussionsupporting

confidence: 91%

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Jakovljević

Milić²,

Bradić

et al. 2018

IJMS

View full text Add to dashboard Cite

The aim of our study was to examine the effects of different dietary strategies, high-fat (HFd) or standard diet (Sd) alone or in combination with standardized oral supplementation (0.45 mL/kg/day) of Aronia melanocarpa extract (SAE) in rats with metabolic syndrome (MetS). SAE is an official product of pharmaceutical company Pharmanova (Belgrade, Serbia); however, the procedure for extraction was done by EU-Chem company (Belgrade, Serbia). Rats were divided randomly into six groups: control with Sd, control with Sd and SAE, MetS with HFd, MetS with HFd and SAE, MetS with Sd and MetS with Sd and SAE during 4 weeks. At the end of the 4-week protocol, cardiac function and liver morphology were assessed, while in the blood samples glucose, insulin, iron levels and systemic redox state were determined. Our results demonstrated that SAE had the ability to lower blood pressure and exert benefits on in vivo and ex vivo heart function. Moreover, SAE improved glucose tolerance, attenuated pathological liver alterations and oxidative stress present in MetS. Obtained beneficial effects of SAE were more prominent in combination with changing dietary habits. Promising potential of SAE supplementation alone or in combination with different dietary protocols in triggering cardioprotection should be further examined in future.

show abstract

Section: Discussionsupporting

confidence: 91%

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Jakovljević

Milić²,

Bradić

et al. 2018

IJMS

View full text Add to dashboard Cite

show abstract

“…This is in line with previous findings showing that natural substances belonging to a group of flavonoids might ameliorate endothelial dysfunction and cardiac hypertrophy in the spontaneously hypertensive rats [26, 27]. Additionally, the beneficial effect of isoflavones on overall cardiovascular markers in models of LV dysfunction, involving enhancement of percent FS, has been proven so far [28].…”

Section: Discussionsupporting

confidence: 91%

Protective Effects ofGalium verum L.Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats

Bradić

Živković

Srejović

et al. 2019

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

Galium verum L. (G. verum, lady’s bedstraw) is a perennial herbaceous plant, belonging to the Rubiaceae family. It has been widely used throughout history due to multiple therapeutic properties. However, the effects of this plant species on functional recovery of the heart after ischemia have still not been fully clarified. Therefore, the aim of our study was to examine the effects of methanol extract of G. verum on myocardial ischemia/reperfusion (I/R) injury in spontaneously hypertensive rats (SHR), with a special emphasis on the role of oxidative stress. Rats involved in the research were divided randomly into two groups: control (spontaneously hypertensive rats (SHR)) and G. verum group, including SHR rats treated with the G. verum extract (500 mg/kg body weight per os) for 4 weeks. At the end of the treatment, in vivo cardiac function was assessed by echocardiography. Rats were sacrificed and blood samples were taken for spectrophotometric determination of systemic redox state. Hearts from all rats were isolated and retrogradely perfused according to the Langendorff technique. After a stabilization period, hearts were subjected to 20-minute ischemia, followed by 30-minute reperfusion. Levels of prooxidants were spectrophotometrically measured in coronary venous effluent, while antioxidant enzymes activity was assessed in heart tissue. Cell morphology was evaluated by hematoxylin and eosin (HE) staining. 4-week treatment with G. verum extract alleviated left ventricular hypertrophy and considerably improved in vivo cardiac function. Furthermore, G. verum extract preserved cardiac contractility, systolic function, and coronary vasodilatory response after ischemia. Moreover, it alleviated I/R-induced structural damage of the heart. Additionally, G. verum extract led to a drop in the generation of most of the measured prooxidants, thus mitigating cardiac oxidative damage. Promising potential of G. verum in the present study may be a basis for further researches which would fully clarify the mechanisms through which this plant species triggers cardioprotection.

show abstract

“…Subcutaneous genistein administration of 0.2 mg/kg/day in ovariectomized New Zealand white female rabbits did not have a protection efect on ischemic myocardium in both nonovariectomized or ovariectomized animals for 4 weeks [35]. Compared to control groups, genistein treatment (600 mg/kg, diet) for 4 weeks in both sexes of C57BL/6J mice made echocardiographic changes in function, increased left ventricle internal dimension (LVIDs), cardiac GLUT4 protein expression, and signifcantly decreased fractional shortening and whole heart surface area [36].…”

Section: In Vivo Studiesmentioning

confidence: 88%

Pharmacological Effects of Genistein on Cardiovascular Diseases

Jafari,

Shoghi,

Khazdair

2023

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Cardiovascular diseases (CVDs) are a group of disorders that involve the heart or blood vessels and are the leading cause of mortality worldwide. Natural products have several pharmacological activities, such as anti-inflammatory, antioxidant, and immunoregulatory properties. This review summarizes the possible therapeutic effects of Genistein on CVD. The information from the current review study was obtained by searching for the keywords such as “Genistein”, “Cardiac dysfunction”, “hypertrophy”, and “Ischemia” “lipid profile” in different online database such as PubMed, Scopus, and Google Scholar, until February 2022. The results of the studies showed that genistein intake has a promising effect on improving cardiac dysfunction, ischemia, and reperfusion of the heart, decreasing cardiac toxicity, modulating lipid profile, and lowering blood pressure. The preventive effects of genistein on experimental models of studies were shown through mechanisms such as anti-inflammatory, antioxidant, and immunomodulatory effects. Pharmacological effects of genistein on cardiac dysfunction, cardiac toxicity, lipid profile, and hypertension indicate the possible remedy effect of this agent in the treatment of CVD.

show abstract

Sex‐Dependent Effects of Dietary Genistein on Echocardiographic Profile and Cardiac GLUT4 Signaling in Mice

Cited by 3 publications

References 43 publications

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Standardized Aronia melanocarpa Extract as Novel Supplement against Metabolic Syndrome: A Rat Model

Protective Effects ofGalium verum L.Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats

Pharmacological Effects of Genistein on Cardiovascular Diseases

Contact Info

Product

Resources

About