Sex-Dependent Effect of Melatonin on Systemic Erythematosus Lupus Developed in Mrl/Mpj-Faslpr Mice: It Ameliorates the Disease Course in Females, whereas It Exacerbates It in Males

Jimenez-Caliani, Antonio J.; Jimenez-Jorge, Silvia; Molinero, Patrocinio; Fernández-Santos, José M.; Martín-Lacave, Inés; Rubio, Amalia; Guerrero, Juan M.; Osuna, Carmen

doi:10.1210/en.2005-0648

Cited by 34 publications

(24 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been shown that melatonin possesses gender-dependent effects on the development of systemic lupus erythematosus. 36 Thus, our gender-specific effects of sildenafil are in the line with the above-mentioned publications.…”

Section: Discussionsupporting

confidence: 89%

Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells

et al. 2015

View full text Add to dashboard Cite

Pancreatic ductal adenocarcinoma (PDAC) represents one of the deadliest cancers in the world. PDAC cells activate tumor-specific immune responses but simultaneously trigger a strong immunosuppression. We showed that PDAC cells produce high amount of chronic inflammatory mediators and PDAC tumors build an immunosuppressive cytokine milieu, which correlates with tumor progression. We observed a low frequency of dendritic cells (DC) and a pronounced accumulation of macrophages and myeloid-derived suppressor cells (MDSC) in murine PDAC tumors. A strong accumulation of MDSC has also been demonstrated in the peripheral blood of resected PDAC patients. While DC and macrophages seem not to play a significant role in this PDAC model in the context of immunosuppression, MDSC are highly suppressive, and their accumulation is associated with an increase in intratumoral VEGF concentration during the PDAC progression. Application of the phosphodiesterase-5 inhibitor sildenafil led to a prolonged survival of PDACbearing female mice, which was due to the decrease in MDSC frequencies and in the systemic VEGF level. This led to a restoration of anticancer immune responses, manifested in the recovery of T lymphocyte functions and in an increase in the frequency of conventional CD4 C T cells in tumors and IFNg level in serum of PDAC-bearing mice. Thus, MDSC are strongly involved in the PDAC-associated immunosuppression and that their depletion could create new approaches for therapy of PDAC.

show abstract

Section: Discussionsupporting

confidence: 89%

Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Several investigations either directly or indirectly supported the relationships between the hormone and the autoimmune process. The administration of melatonin in female lupus MRL/MP-fas mice reduced the levels of autoantibodies and improved the histological changes (22). Since the hormone was added to the drinking water, the exact time of melatonin application could not be specified in the latter study, but it could be of clinical importance.…”

Section: Discussionmentioning

confidence: 99%

Decreased Daily Melatonin Levels in Women with Systemic Lupus Erythematosus - A Short Report

et al. 2013

View full text Add to dashboard Cite

“…Melatonin administered in the morning increased the survival of lupus-prone animals, although the effect was not reproduced after evening treatment [255]. Additionally, melatonin reduced vascular lesions and inflammatory infiltration in the kidneys, diminished titers of anti-collagen II and anti-dsDNA autoantibodies, reduced the production of pro-inflammatory cytokines and increased the release of anti-inflammatory cytokines in both female lupus-prone animals [256] and pristane-induced lupus [257]. However, melatonin had no effect or actually worsened the disease in male lupus-prone mice [256].…”

Section: Clinical Relevance Of Melatoninmentioning

confidence: 99%

Melatonin: Buffering the Immune System

Carrillo-Vico

Lardone

Álvarez-Sánchez

et al. 2013

IJMS

577

455

View full text Add to dashboard Cite

Melatonin modulates a wide range of physiological functions with pleiotropic effects on the immune system. Despite the large number of reports implicating melatonin as an immunomodulatory compound, it still remains unclear how melatonin regulates immunity. While some authors argue that melatonin is an immunostimulant, many studies have also described anti-inflammatory properties. The data reviewed in this paper support the idea of melatonin as an immune buffer, acting as a stimulant under basal or immunosuppressive conditions or as an anti-inflammatory compound in the presence of exacerbated immune responses, such as acute inflammation. The clinical relevance of the multiple functions of melatonin under different immune conditions, such as infection, autoimmunity, vaccination and immunosenescence, is also reviewed.

show abstract

Sex-Dependent Effect of Melatonin on Systemic Erythematosus Lupus Developed in Mrl/Mpj-Faslpr Mice: It Ameliorates the Disease Course in Females, whereas It Exacerbates It in Males

Cited by 34 publications

References 42 publications

Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells

Characterization of myeloid leukocytes and soluble mediators in pancreatic cancer: importance of myeloid-derived suppressor cells

Decreased Daily Melatonin Levels in Women with Systemic Lupus Erythematosus - A Short Report

Melatonin: Buffering the Immune System

Contact Info

Product

Resources

About