Sex‐dependent correlates of arterial stiffness in Tanzanian adults

Karand, Julie C; Reis, Karl; Stephano, Ponsiano F; Gargurevich, Nick; Zhou, Joanne; Desderius, Bernard; Fadhil, Salama; Ladha, Yumna; Rosengard, Rachel; Kowal, Daniel R.; Peck, Robert

doi:10.1111/tmi.13676

Cited by 1 publication

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The risk of cardiovascular events, namely myocardial infarction, heart failure and stroke, among persons with HIV (PWH) is roughly two-fold higher compared to HIV-negative persons [1]. Increased cardiovascular risk in PWH is multifactorial and includes chronic innate and adaptive immune activation, dyslipidaemias, insulin resistance, and other factors [2][3][4]. Prior studies have also implicated impaired vascular compliance, or a reduced ability for blood vessel walls to expand and contract passively with changes in pressure [5], as a common finding in PWH and a possible mechanism contributing to this increased CVD risk.…”

Section: Introductionmentioning

confidence: 99%

Vascular dysfunction and body mass index in African adults with HIV

Kaluba

Chikopela

Goma

et al. 2023

BMC Cardiovasc Disord

View full text Add to dashboard Cite

Background Impaired vascular compliance is common among persons with HIV (PWH) and a risk factor for cardiovascular disease (CVD), though many studies documenting this are from regions with a high prevalence of overweight and obesity. The prevalence and characteristics of impaired vascular compliance among PWH with low body mass index (BMI) is not well described, particularly in sub-Saharan Africa (SSA) where the majority of PWH live, a low BMI is more common, and the burden of CVD is rising. Aim To assess non-invasive vascular compliance measurements, including augmentation index (AIX), pulse wave velocity (PWV) and pulse waveforms, in underweight, normal weight, and overweight PWH on long-term antiretroviral therapy (ART) in SSA. Methods A cross-sectional study among PWH on ART at the University Teaching Hospital in Lusaka, Zambia. All participants had been on a regimen of efavirenz, emtricitabine, and tenofovir disoproxil fumarate for five or more years. Carotid-femoral PWV (cfPWV), carotid-radial PWV (crPWV), and the corresponding augmentation indexes (cfAIX and crAIX), were measured in all participants, in addition to aortic pressure waveforms, classified as type A, B, C and D according to reflected wave timings and amplitude. Multiple linear regression assessed relationships between demographic and clinical factors with vascular measurement endpoints. Results Ninety one PWH on long-term ART were enrolled; 38 (42%) were underweight (BMI < 18.5 kg/m2), 43 (47%) were normal weight (18.5–24.9 kg/m2) and 10 (11%) were overweight (> 25 kg/m2). Median age was 41, 40 and 40 years, among the three groups, respectively, and the proportion of women increased with BMI level. Overweight participants had a 39% higher cfAIX compared to normal-weight participants, while being underweight was associated with 27% lower cfAIX, after adjusting for age, sex and blood pressure (P = 0.02 and P = 0.01, respectively), but measurements of cfPWV, crPWV and crAIX did not differ. Conclusion Underweight PWH in SSA had lower cfAIX measurements compared to normal weight individuals, indicating less arterial stiffness. However, similar cfPWV, crPWV and crAIX values among the underweight and overweight PWH suggest a low BMI may not confer substantial protection against impaired vascular compliance as a contributor to CVD risk among individuals on ART.

show abstract