Sex-Dependency of T Cell-Induced Salt-Sensitive Hypertension and Kidney Damage
Justine M. Abais-Battad,
John Henry Dasinger,
Hayley Lund
et al.
Abstract:BACKGROUND:
It is established that the immune system, namely T cells, plays a role in the development of hypertension and renal damage in male Dahl salt-sensitive (SS) rats, but far less is known about this relationship in females. Rats with genetically deleted T cells via
CD247
gene mutation on the Dahl SS background (SS
CD247−/−
) were utilized to interrogate the effect of sex and T cells on salt sensitivity.
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