Sex dependence of clearance rates of aldosterone and its metabolites from plasma of intact rats

Morris, David J.; Caron, Philip; Graham, William C.; Silverman, Jill A.; Deconti, Giulio A.

doi:10.1016/0039-128x(75)90040-9

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…The lack of parallel changes in the number and average volume of zona glomerulosa cells and their organelles [25] would suggest that this decline depends mainly on extraadrenal factors, among which is an altered distribution of that hormone in the body fluid, due to an elevated volume of extravascular space (as evidenced by the higher body weight of pregnant hamsters). Moreover, aldosterone binds to specific carrier proteins only to a small degree, so that, at least in rats [23], its biological half-life is notably shorter than that of glucocorticoids. This finding is in apparent contrast to the data concerning the level of aldosterone in the blood of pregnant women, where a marked stimulation of the renin-angiotensin system is responsible for the enhanced plasma concentration of this hormone (for review, see [13]).…”

Section: Discussionmentioning

confidence: 99%

Gestational changes in hamster adrenal cortex: stereologic and functional studies

Nowak¹,

Nussdorfer

Nowak³

et al. 1990

Res. Exp. Med.

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Pregnancy in hamsters evoked a prompt increase in adrenal weight, with the highest value at day 5 and a subsequent fall toward the end of gestation. The surface densities of mitochondrial cristae and smooth endoplasmic reticulum did not display significant changes in the course of gestation, while lll3-hydroxylase and 313-hydroxysteroid dehydrogenase/isomerase activity (two enzymes located in these two organelles) underwent significant increases at day 5 and day 10 of pregnancy, respectively. Neither the adrenal content of cortisot nor cortisol output by adrenal homogenates changed, but cortisol production measured in adrenal slices gradually rose during the course of pregnancy. Blood cortisol concentration increased about ten-fold toward the end of gestation, whereas the plasma ACTH level remained unchanged and plasma aldosterone concentration was significantly lowered. The conclusion is drawn that the pregnant hamster's adrenal glands possess an enhanced capacity to secrete cortisol, but the factor(s) involved remain unknown.

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Section: Discussionmentioning

confidence: 99%

Gestational changes in hamster adrenal cortex: stereologic and functional studies

Nowak¹,

Nussdorfer

Nowak³

et al. 1990

Res. Exp. Med.

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“…In addition, oestrogens, progestogens, gluco-and mineralo-corticoids, by affecting electrolyte and water balances (Johnson, Davis, Baumber & Schneider, 1970;Oparil, Ehrlich & Lindheimer, 1975;Johnson, Davis, Brown, Wheeler & Witty, 1972;Deis, Lloyd & Pickford, 1963;Laragh & Sealey, 1973) alter synthetic and release mechanisms, which may themselves change in sensitivity to ADH. These considerations, together with known male-female differences in cardiovascular reactivity, sympathetic tone (Albrecht, 1974;Buiiag, Walaszek & Mueting, 1975;Bufiag, 1976), and adrenocortical function, in particular aldosterone metabolism (Morris, Caron, Graham, Silverman & De Conti, 1975;Morris, Berek & Davis, 1973), clearly allow considerable sexual variation in the properties of renin-release mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Vasopressin Effects on Plasma Renin Activity in Male and Female Rats

1978

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1. The influence of gonadal and pituitary factors on the plasma renin response to exogenous vasopressin was examined in anaesthetized rats.2. Plasma renin activity (PRA) was measured in Brattleboro rats (with and without hypothalamic diabetes insipidus) and Long-Evans male and female rats, before and after single intravenous injection of antidiuretic hormone (ADH) or saline.3. Control saline injections did not change PRA. ADH reduced PRA in male, but increased PRA in female rats. Rats with diabetes insipidus displayed the greatest changes and were used in subsequent experiments. Extrarenal renin activity (nephrectomized rats) gave qualitatively similar responses to ADH. Plasma renin concentration, which was also measured with PRA in intact and nephrectomized male and female rats with diabetes insipidus, increased in the females and decreased in the males after ADH.4. Castration, 24 h before study, abolished the ADH-induced fall in PRA, and testosterone implanted before castration did not restore the response. Cyproterone acetate reversed the ADH effect in males, so that PRA then rose after ADH. Hypophysectomized male rats, with depressed basal plasma renin activities, also showed a reduced PRA after ADH. 5. Ovariectomy had little effect on the ADHinduced renin release and the response was similar at oestrus, metoestrus and dioestrus. In hypophysectomized female rats ADH reduced PRA; a *Present address: Department of Zoology, University of Correspondence: Dr I. W. Henderson, Department of Manchester, Manchester M13 9PL, U.K.Zoology, University of Sheffield, Sheffield S10 2TN, U.K. male pattern of response was seen in hypophysectomized female rats.6. In both sexes PRA responses to ADH were blunted but not abolished by Padrenergic blockade (propranolol). a-Adrenergic blockade (phenoxybenzamine) had little influence on the male response but in females the typical increase disappeared so that ADH reduced PRA.7. It is concluded that pituitary hormones, including gonadotrophins and gonadal factors as well as adrenal sex steroids, appear to affect significantly the interplay between antidiuretic hormone and the renin-angiotensin system.

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Regulation of plasma levels of aldosterone and its metabolites during the latent period of aldosterone

Morris

Tsai

Deconti

1976

Journal of Steroid Biochemistry

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Sex dependence of clearance rates of aldosterone and its metabolites from plasma of intact rats

Cited by 11 publications

References 19 publications

Gestational changes in hamster adrenal cortex: stereologic and functional studies

Gestational changes in hamster adrenal cortex: stereologic and functional studies

Vasopressin Effects on Plasma Renin Activity in Male and Female Rats

Regulation of plasma levels of aldosterone and its metabolites during the latent period of aldosterone

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