Sex cord‐stromal tumours of the ovary

Fox, H.

doi:10.1002/path.1711450202

Cited by 75 publications

(36 citation statements)

References 121 publications

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“…Sertoli cell differentiation has been seen in mouse granulosa cell tumors (28), and Knowles (35) also described mixtures of both elements in rat ovarian tumors induced by ENU coupled with radiation treatment. There is a degree of architectural and cytological overlap between these two neoplasms in human beings (36). Mixed tumors observed in the present study indicate that Sertoli and granulosa cell elements are homologous, with a common origin from the sex cord.…”

Section: Discussionsupporting

confidence: 46%

Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Maekawa

Oda²,

Tanigawa³

et al. 1987

Environ Health Perspect

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Spontaneous ovarian tumors are very rare in ACI, Wistar, F344 and Donryu rats; the few neoplasms found are of the granulosa/theca cell type. Ovarian tumors were also rare in these strains of rats when given high doses ofN-alkyl-N-nitrosoureas continuously in the drinking water for their life-span; however, relatively high incidences of Sertoli cell tumors or Sertoli cell tumors mixed with granulosa cell tumors were induced in Donryu rats after administration of either a 400 ppm N-ethyl-N-nitrosourea solution in the drinking water for 4 weeks or as a single dose of 200 mg N-propyl-N-nitrosourea per kg body weight by stomach tube. Typical Sertoli cell tumors consisted of solid areas showing tubular formation. The tubules were lined by tall, columnar cells, with abundant, faintly eosinophilic, often vacuolated cytoplasm, and basally oriented, round nuclei, resembling seminiferous tubules in the testes. In some cases, Sertoli cell tumor elements were found mixed with areas of granulosa cells.The induction of ovarian Sertoli cell tumors in Donryu rats by low doses of nitrosoureas may provide a useful model for these tumors in man.

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Section: Discussionsupporting

confidence: 46%

Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Maekawa

Oda²,

Tanigawa³

et al. 1987

Environ Health Perspect

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“…Symptoms of androgen excess are associated with a tumoral pathology in !1% of women of all ages (2)(3)(4)(5). Androgen-producing ovarian tumors include lipoid, Leydig cell, granulosa-theca cell, and Sertoli-stromal cell tumors (6,7). Adrenal androgen-secreting tumors are rare but highly suggestive of malignancy (8).…”

Section: Introductionmentioning

confidence: 99%

Impact of clinical, hormonal, radiological, and immunohistochemical studies on the diagnosis of postmenopausal hyperandrogenism

Sarfati

Bachelot

Coussieu

et al. 2011

European Journal of Endocrinology

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Objective: Evaluation of postmenopausal women with suspicion of androgen-secreting tumor. Design and patients: We retrospectively studied 22 postmenopausal women referred to our center for suspicion of androgen-secreting tumor. All patients had clinical, biological, and morphological evaluation. In absence of adrenal tumors, ovarian surgery was most often proposed and immunohistochemistry (IHC) studies were performed. Results: Ovarian tumors were detected by ultrasound and/or magnetic resonance imaging in eight patients. Two adrenal androgen-secreting tumors were diagnosed by an adrenal computed tomography (CT) scan. The clinical presentation of the women with or without tumors was similar. Nevertheless, women with tumor exhibited significantly higher testosterone levels and lower basal FSH and LH levels than the other women (2.6G2.7 vs 0.9G0.9 ng/ml, P!0.05; 26.5G22.9 vs 66.5G 26.0 IU/l, P!0.01; and 12.0G8.6 vs 24.1G8.9 IU/l, P!0.05 respectively). Based on a likelihood ratio test, patients with a tumor had 8.4 and 10.8 times higher risk of having a testosterone level R1.4 ng/ml or an FSH level %35 IU/l. Finally, IHC analysis with an anti-P450c17a antibody allowed the identification of an elevated number of ovarian androgen-producing cells in five patients in whom no tumor was found. Conclusions: Androgen-secreting tumors are clinically difficult to discriminate from other causes of postmenopausal hyperandrogenism. Testosterone and FSH were the two discriminative markers in a multivariate analysis. Ovarian and adrenal tumors were detected by imaging studies. However, ovarian non-tumoral causes of hyperandrogenism may be difficult to detect with conventional histology.

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“…Apart from his clearly delineating the Brenner tumor as a distinctive neoplasm separate from other tumors with an insular pattern such as the granulosa cell tumor (and instituting the now famous eponymous designation for the former tumor), he elaborated on the various morphologic features of the granulosa cell tumor to a degree greater than had been done before. The history of the granulosa cell tumor was nicely summarized by the eminent British pathologists Drs Harold Fox and Fred Langley 84 in their book (one of many strengths of which is good consideration of the historical background to the entities they discuss). They and others 56 credit the great Rokitansky with perhaps first describing what we now know as the granulosa cell tumor, but it was not until 1895 that von Kahlden 85 described the histologic features of this tumor in detail and the designation 'granulosa cell tumor' was only introduced in 1914 by von Werdt.…”

Section: The Ovarymentioning

confidence: 99%

“…142 The start of the 1970s saw the publication of an excellent monograph on ovarian tumors by the Czech investigator, Karel Motlik. 144 The remaining years of that decade saw the publication of two notable books, the previously mentioned 'Tumors of the Ovary' by Drs Fox and Langley, 84 and the second series fascicle 'Tumors of the Ovary and Maldeveloped Gonads' by Dr Scully. 145 Although many fine contributions by workers of the current generation have ensued it is perhaps appropriate to end our story at this time with those outstanding books, one from each side of the Atlantic, and leave the 'rest of the story' for another day.…”

Section: The Ovarymentioning

confidence: 99%

A brief history of the pathology of the gonads

Young

2005

Mod Pathol

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Our understanding of gonadal pathology has reached its current state as a result of the contributions of numerous outstanding investigators. Knowledge of testicular tumor pathology dates back to the great British workers Percival Pott and Sir Astley Cooper but the single greatest early stride was made with the description in 1906 by the French urologist Maurice Chevassu of the seminoma. The seminal 1946 paper of Nathan B Friedman and Robert A Moore, which segregated out as a distinct entity embryonal carcinoma, is, however, the foundation for the current classification of testicular tumors. In that year Pierre Masson described the distinctive neoplasm, the spermatocytic seminoma. The 1950s saw the publication of an important paper by Frank J Dixon and Dr Moore and they also wrote the first series fascicle on testicular tumors. In this same timeframe, and thereafter, Robert E Scully made significant contributions to testicular pathology, writing the first English language paper on spermatocytic seminoma, describing several subtypes of sex cord tumor, and also the distinctive lesion of intersex, the gonadoblastoma, as well as playing a major role in 1980 in formulating the current classification of premalignant lesions of the testis. The current classification of testicular tumors was arrived at in the early 1970s when the World Health Organization, under the leadership of Dr FK Mostofi, who himself made notable contributions to testicular pathology, devised what is fundamentally the current classification of neoplasms of the male gonad. Although comments on ovarian pathology were made by such legendary figures of earlier times as Giovanni Battista Morgagni and Matthew Baillie, it is only in the mid to later years of the 19th century that contributions, mostly in Europe, began to move knowledge of ovarian pathology to its current state. Thomas Hodgkin, Richard Bright, and Sir James Paget all wrote extensively on ovarian neoplasms. In 1870, Heinrich Waldeyer, and later in that century, another German, Hermann Johannes Pfannenstiel wrote important papers on the surface epithelial tumors. The latter was likely the first to refer to neoplasms now known as of 'borderline malignancy' and also wrote on pseudomyxoma peritonei and other topics. Their work was followed by that of Robert Meyer who made monumental contributions to gynecological pathology, including recognizing the Brenner tumor as a distinctive neoplasm and proposing the first classification of Sertoli-Leydig cell tumors (arrhenoblastomas). He also coined the term 'disgerminoma' (soon changed to dysgerminoma) for the ovarian tumor that had been described in detail by the French investigator Marcel Chenot 5 years after Chevassu had mentioned the tumor in his paper describing the seminoma. During the Meyer era other significant contributions were made by, among others, Howard C Taylor writing on the borderline tumors and John A Sampson writing on endometriosis and tumors, associated with it. In the second-half of the 20th century major contributions were made b...

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Sex cord‐stromal tumours of the ovary

Cited by 75 publications

References 121 publications

Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Experimental induction of ovarian Sertoli cell tumors in rats by N-nitrosoureas.

Impact of clinical, hormonal, radiological, and immunohistochemical studies on the diagnosis of postmenopausal hyperandrogenism

A brief history of the pathology of the gonads

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