Sex cord-stromal tumors of the ovary: road map for progress

Hillman, R. Tyler; Gershenson, David M.

doi:10.1136/ijgc-2020-002329

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…Ovarian sex cord-stromal tumors, which can present as various morphology and clinical behavior, account for 7% of all ovarian tumors. [1][2][3] These tumors are thought to originate from sex cords or stromal cells, and the former consists of granulosa cells and Sertoli cells, but the latter comprises theca cells, Leydig cells and fibroblasts. [4,5] The cell types mentioned above can separately form a tumor or together with another.…”

Section: Introductionmentioning

confidence: 99%

Fibrothecoma of broad ligament with minor sex cord elements: Case report and brief literature review

2023

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Rationale: Sex cord-stromal tumors are always found in ovary, but the occurrence of this kind of tumor at extraovarian locations is extremely rare. Up to now, the case concerning fibrothecoma of broad ligament with minor sex cord elements has not been reported, and it is extremely challenging to diagnose before surgery. In this case report, we summarized pathogenesis, clinical features, laboratory finding, imaging studies, pathology, and therapeutic schedule of this tumor, with the aim of raising awareness and attention to this type of disease.Patient concerns: A 45-year-old Chinese woman was referred to our department with intermittent lower abdominal pain for about 6 years. On examination, both ultrasonography and computed tomography revealed she had a right adnexal mass.Diagnosis: Based on the results of histology and immunohistochemistry, the final diagnosis was confirmed as fibrothecoma of broad ligament with minor sex cord elements.Interventions: This patient underwent laparoscopic unilateral salpingo-oophorectomy with excision of the neoplasm.Outcomes: Eleven days post-treatment, the patient complained that the symptoms of abdominal pain was disappeared. There is no evidence of disease recurrence 5 years after laparoscopic surgery according to the consequences of radiologic examination Conclusion:The natural history of this kind of tumor is uncertain. Although main treatment of this neoplasm might be surgical resection and good prognosis can be achieved, we believe that long-time follow-up is extremely important in all patients diagnosed as fibrothecoma of broad ligament with minor sex cord. Laparoscopic unilateral salpingo-oophorectomy with excision of the tumor should be recommended to these patients.

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Section: Introductionmentioning

confidence: 99%

Fibrothecoma of broad ligament with minor sex cord elements: Case report and brief literature review

2023

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“…The ovarian granulosa cell normally produces the inhibin glycoprotein which has a negative feedback effect on the pituitary production of follicle-stimulating hormone (FSH). Higher levels of inhibin hormone might be a marker of primary or recurrent AOGCT in postmenopausal women [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Adult-Type Ovarian Granulosa Cell Tumour: Treatment Outcomes From a Single-Institution Experience

Alhusaini¹,

Elshenawy²,

Badran³

et al. 2022

Cureus

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Objectives: Ovarian granulosa cell tumour is rare. This study aims to report the clinical characteristics and long-term outcomes of adult-type ovarian granulosa cell tumour (AOGCT) at King Faisal Specialist Hospital and Research Centre (KFSH&RC) and to determine the prognostic factors affecting relapse and survival.Methods: We retrospectively reviewed patients with AOGCT, from 1988 to 2014, who were treated at our institution. Baseline characteristics, pathological findings, and outcomes were analysed and reported.Results: Sixty-one patients with AOGCT were identified with a median age of 49 years. Median follow-up was 5.0 years (range 2.1-8.2 years). 74% of patients were FIGO (International Federation of Gynecology and Obstetrics) stage I, whereas 7% were stage II, 5% were stage III, and unknown in 14% of the cases. The most common presenting symptoms included abdominal pain (43%) and vaginal bleeding (43%). The majority of patients (38 patients, 62%) were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy. Five (8%) patients received adjuvant chemotherapy. Sixteen patients (26%) relapsed with a median time to relapse of 5.5 years (0.7-8.1 years). Half of the recurrences (eight patients, 50%) occurred after five years of diagnosis. Five-year overall survival and disease-free survival (DFS) were 93% and 84%, respectively. Factors associated with a high risk of recurrence were the presence of ascites (p=0.000) and elevated preoperative CA 125 level (p=0.048). The overall survival was significantly influenced by the menopausal status (premenopausal 100% vs. postmenopausal 84%; p=0.02), preoperative CA 125 (normal 100% vs. elevated 64%; p=0.005), ascites (present 33% vs. absent 100%; p=0.000), and age (<55 years 100% vs. ≥ 55 years 77%; p= 0.002). Conclusion:This study confirms a good outcome for patients with AOGCT. They require long-term follow-up as late recurrences can occur many years post definitive therapy. The presence of ascites and elevated preoperative CA 125 levels were associated with a higher risk of recurrence and poor prognosis. Outcomes appear unaffected by fertility-sparing surgery or adjuvant chemotherapy.

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Sex cord-stromal tumors of the ovary: road map for progress

Cited by 2 publications

References 9 publications

Fibrothecoma of broad ligament with minor sex cord elements: Case report and brief literature review

Fibrothecoma of broad ligament with minor sex cord elements: Case report and brief literature review

Adult-Type Ovarian Granulosa Cell Tumour: Treatment Outcomes From a Single-Institution Experience

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