Sex combs find middle ground in evolution debate

Abouheif, Ehab; Rafiqi, Ab. Matteen

doi:10.1073/pnas.1415189111

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Morphallaxis and Self-regulation: Is The Tumor An Organ?1

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2017

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“…As the saying goes, “Mutation proposes, selection disposes” 101 . Error-prone mechanisms of DNA replication fit this description of randomness.…”

Section: Morphallaxis and Self-regulation: Is The Tumor An Organ?mentioning

confidence: 99%

Evolutionary scalpels for dissecting tumor ecosystems

Rosenbloom

Cámara

Chu

et al. 2017

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

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Amidst the growing literature on cancer genomics and intratumor heterogeneity, essential principles in evolutionary biology recur time and time again. Here we use these principles to guide the reader through major advances in cancer research, highlighting issues of “hit hard, hit early” treatment strategies, drug resistance, and metastasis. We distinguish between two frameworks for understanding heterogeneous tumors, both of which can inform treatment strategies: (1) The tumor as diverse ecosystem, a Darwinian population of sometimes-competing, sometimes-cooperating cells; (2) The tumor as tightly integrated, self-regulating organ, which may hijack developmental signals to restore functional heterogeneity after treatment. While the first framework dominates literature on cancer evolution, the second framework enjoys support as well. Throughout this review, we illustrate how mathematical models inform understanding of tumor progression and treatment outcomes. Connecting models to genomic data faces computational and technical hurdles, but high-throughput single-cell technologies show promise to clear these hurdles.

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“…As the saying goes, “Mutation proposes, selection disposes” 101 . Error-prone mechanisms of DNA replication fit this description of randomness.…”

Section: Morphallaxis and Self-regulation: Is The Tumor An Organ?mentioning

confidence: 99%