Sex Chromosomal Genes in Male Infertility

Singh, Vertika; Singh, Kiran; Rajender, Singh

doi:10.1007/978-981-10-4017-7_15

Cited by 2 publications

(1 citation statement)

References 86 publications

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“…Because the mitochondrial genome is exclusively maternally transmitted (Frank & Hurst, 1996; Pominankowski, 1999), a selection response against male‐detrimental mitochondrial genes or for male‐beneficial genes is not possible in a randomly mating population. In human fertility studies, mitochondria are “the most important organelles for the evaluation of sperm quality ” (Luo et al, 2013; Nakada et al, 2006) and Y chromosome microdeletions are the most common cause of human male infertility (Bansal et al, 2017).…”

Section: Supporting Evidence and Discussionmentioning

confidence: 99%

Adaptive co‐evolution of mitochondria and the Y‐chromosome: A resolution to conflict between evolutionary opponents

Wade

Fogarty

2021

Ecology and Evolution

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Males appear to be an evolutionary dead end for mitochondria and other organelles with uniparental, maternal inheritance. Moreover, adaptive evolution of mitochondrial genes affecting fitness of females, the transmitting sex, can have deleterious fitness effects on males, the non-transmitting sex (a phenomenon known as "mother's curse"; Partridge & Hurst, 1998). Although mitochondria are essential to sperm motility, mitochondria have been considered evolutionarily "…unavailable as an avenue for adaptive evolution of sperm phenotype" (Zeh, 2004, p. S307). Moreover, traits related to reproduction that are "strongly sexually dimorphic or sex limited in expression (e.g., traits related to reproduction), are predicted to be those most vulnerable to the build-up of an underlying male-specific mitochondrial mutation load" (Beekman et al., 2014, p. 2). As pointed out by Gemmell et al. (2004), this seemingly important role of small

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Section: Supporting Evidence and Discussionmentioning

confidence: 99%

Adaptive co‐evolution of mitochondria and the Y‐chromosome: A resolution to conflict between evolutionary opponents

Wade

Fogarty

2021

Ecology and Evolution

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Reproductive effects of sulfoxaflor in male Sprague Dawley rats

Mohamed

Ali

Yahia

et al. 2022

Environ Sci Pollut Res

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The study objective was to evaluate the potential reproductive toxicity of sulfoxaflor (SFX) insecticide in male Sprague Dawley rats. To attain these objectives, forty male Sprague Dawley rats of 10–12 weeks old were randomly divided into four equal groups; the 1st group was used as a control group; the other three groups were exposed to 25, 100, and 500 mg/kg body weight SFX by oral gavage for 4 weeks. Relative testicular weight, testosterone, FSH, LH, MDA, and GPx levels, sperm viability, sperm morphology, sperm DNA damage, and histopathological changes in testes, epididymis, and seminal vesical of these rats were investigated after 4 weeks. The results showed that SFX exposure resulted in a significant increase in FSH, LH, MDA, and GPx levels as well as the percentage of dead and abnormal sperms and DNA damage in rat sperms. Histopathological examination of testes established testicular degeneration with coagulative necrosis as well as the proliferation of interstitial connective tissue infiltrated with inflammatory cells with congestion of intertubular blood vessels in epididymis and degeneration of lining epithelium of seminal vesicles.

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Sex Chromosomal Genes in Male Infertility

Cited by 2 publications

References 86 publications

Adaptive co‐evolution of mitochondria and the Y‐chromosome: A resolution to conflict between evolutionary opponents

Adaptive co‐evolution of mitochondria and the Y‐chromosome: A resolution to conflict between evolutionary opponents

Reproductive effects of sulfoxaflor in male Sprague Dawley rats

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