Sex-based fMRI differences in obese humans in response to high vs. low energy food cues

Geliebter, Allan; Pantazatos, Spiro P.; McOuatt, Haley; Puma, L; Gibson, Charlisa D.; Atalayer, Deniz

doi:10.1016/j.bbr.2012.12.023

Cited by 64 publications

(87 citation statements)

References 33 publications

(40 reference statements)

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“…Analyses of auditory cues and non-food stimuli will not be presented. Main sex-based differences in BOLD activations in response to high-ED > low-ED food cues during fed and fasted states are reported elsewhere (Geliebter et al, 2013). …”

Section: Methodsmentioning

confidence: 65%

“…Normal weight women compared with normal weight men showed greater responses to taste and olfactory stimulation in the insula (Uher et al, 2006), and greater responses to high vs. low energy food pictures (when fasted [≥ 3hours]), in fusiform gyrus (Frank et al, 2010). We recently reported that when fasted, obese women showed higher activation in response to high vs. low-ED visual food cues in the caudate (Geliebter et al, 2013), which is a brain area implicated in reward processing and craving (Pelchat et al, 2004). Other studies have reported a greater activation in response to food pictures with high hedonic value in fasting normal weight women (compared with men) in the dorsolateral prefrontal cortex (Cornier et al, 2010), a region implicated in inhibitory control (Diamond, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Sexually dimorphic functional connectivity in response to high vs. low energy-dense food cues in obese humans: An fMRI study

et al. 2014

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Sexually-dimorphic behavioral and biological aspects of human eating have been described. Using psychophysiological interactions (PPI) analysis, we investigated sex-based differences in functional connectivity with a key emotion-processing region (amygdala, AMG) and a key reward-processing area (ventral striatum, VS) in response to high vs. low energy-dense (ED) food images using blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) in obese persons in fasted and fed states. When fed, in response to high vs. low-ED food cues, obese men (vs. women) had greater functional connectivity with AMG in right subgenual anterior cingulate, whereas obese women had greater functional connectivity with AMG in left angular gyrus and right primary motor areas. In addition, when fed, AMG functional connectivity with pre/post-central gyrus was more associated with BMI in women (vs. men). When fasted, obese men (vs. women) had greater functional connectivity with AMG in bilateral supplementary frontal and primary motor areas, left precuneus, and right cuneus, whereas obese women had greater functional connectivity with AMG in left inferior frontal gyrus, right thalamus, and dorsomedial prefrontal cortex. When fed, greater functional connectivity with VS was observed in men in bilateral supplementary and primary motor areas, left postcentral gyrus, and left precuneus. These sex-based differences in functional connectivity in response to visual food cues may help partly explain differential eating behavior, pathology prevalence, and outcomes in men and women.

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Section: Methodsmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

Sexually dimorphic functional connectivity in response to high vs. low energy-dense food cues in obese humans: An fMRI study

et al. 2014

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“…For instance, we recently observed a sex difference in the response of body composition to early nutrition in preterm infants (16). Moreover, the role of sex in human eating has been previously documented in obese adults; a recent study (17) showed that obese women had greater neural activation in regions associated with cognition and emotionrelated brain regions than did obese men. Thus, a role of sex on eating behaviors at age 2 y is possible but must be confirmed in future studies.…”

Section: Discussionmentioning

confidence: 96%

Effect of preterm birth and birth weight on eating behavior at 2 y of age

Migraine¹,

Nicklaus²,

Parnet³

et al. 2013

The American Journal of Clinical Nutrition

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Preterm children have more eating difficulties than term children do, but after adjustment for maternal and neonatal characteristics, gestational age is not associated with impaired eating behaviors at the age of 2 y. Female sex, a low maternal level of education, and less than -1 SD intrauterine growth are associated with eating difficulties at 2 y of age. This trial was registered at clinicaltrials.gov as NCT 00663572.

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“…Malefemale sex differences in brain activation in response to the flavors of normal foods (176,675), to pure tastes (299), and to pictures of food (135,231,264,378,748) have been reported. In a recent review of this literature, Geliebter et al (264) concluded that if brain areas are classed by their predominate functions, as described above, pictures of food stimuli elicit more activation in areas related to planning and executing behaviors in men and more activation in areas related to cognitive and affective processes in women. This conclusion, although certainly generally correct, belies the complexity of the data obtained in these studies.…”

Section: R1243 Sex Differences In the Physiology Of Eatingmentioning

confidence: 99%

“…Haase at al. (299) studied brain responses to intraoral infusions of 0.3 ml 0.04 M caffeine (bitter), 0.01 M citric acid (sour), 0.64 M sucrose (sweet) or 0.16 M NaCl (salty) in normal-weight men and women during fed and fasted states [using a method similar to that of Geliebter et al (264) described above]. Indeed, only two sex differences in brain responses to sucrose between the fed and fasted states were detected-the differential responses were larger in men than women in the insula and cerebellum (sex differences for other tastes occurred in several other areas).…”

Section: R1243 Sex Differences In the Physiology Of Eatingmentioning

confidence: 99%

Sex differences in the physiology of eating

Asarian

Geary²

2013

American Journal of Physiology-Regulatory, Integrative and Comp

390

338

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(HPG) axis function fundamentally affects the physiology of eating. We review sex differences in the physiological and pathophysiological controls of amounts eaten in rats, mice, monkeys, and humans. These controls result from interactions among genetic effects, organizational effects of reproductive hormones (i.e., permanent early developmental effects), and activational effects of these hormones (i.e., effects dependent on hormone levels). Male-female sex differences in the physiology of eating involve both organizational and activational effects of androgens and estrogens. An activational effect of estrogens decreases eating 1) during the periovulatory period of the ovarian cycle in rats, mice, monkeys, and women and 2) tonically between puberty and reproductive senescence or ovariectomy in rats and monkeys, sometimes in mice, and possibly in women. Estrogens acting on estrogen receptor-␣ (ER␣) in the caudal medial nucleus of the solitary tract appear to mediate these effects in rats. Androgens, prolactin, and other reproductive hormones also affect eating in rats. Sex differences in eating are mediated by alterations in orosensory capacity and hedonics, gastric mechanoreception, ghrelin, CCK, glucagon-like peptide-1 (GLP-1), glucagon, insulin, amylin, apolipoprotein A-IV, fatty-acid oxidation, and leptin. The control of eating by central neurochemical signaling via serotonin, MSH, neuropeptide Y, Agouti-related peptide (AgRP), melanin-concentrating hormone, and dopamine is modulated by HPG function. Finally, sex differences in the physiology of eating may contribute to human obesity, anorexia nervosa, and binge eating. The variety and physiological importance of what has been learned so far warrant intensifying basic, translational, and clinical research on sex differences in eating.neuroendocrinology; estrogens; testosterone; eating disorders; obesity SEX DIFFERENCES ARE PERVASIVE in physiology and medicine (51,64,73,109,110,466,797,826). The controls of eating and energy homeostasis are no exceptions. It was observed approximately 100 years ago that removal of the ovaries leads to marked accretion of adipose tissue in rats (697), that daily food intake expressed as kilocalories per gram body weight differs between male and female rats (778), and that food intake varies regularly through the ovarian cycle in intact female rats (674, 779). Sex differences in eating have been the subject of physiological research ever since. The clinical relevance of this work is increasingly evident. In the United States, women are approximately threefold more vulnerable than men to psychiatric eating disorders (346,351) and approximately twofold more vulnerable to severe and morbid obesity (BMI Ն 35 and 40 kg/m 2 , respectively, mass/height 2 ) (226). Women also appear to suffer more from these disorders in terms of physical and psychological functioning and quality of life (24,84,273,292,465,531,762). The increased obesity burden suffered by women is reflected in the fact that Ͼ80% of bariatric surgery patients in the U...

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Sex-based fMRI differences in obese humans in response to high vs. low energy food cues

Cited by 64 publications

References 33 publications

Sexually dimorphic functional connectivity in response to high vs. low energy-dense food cues in obese humans: An fMRI study

Sexually dimorphic functional connectivity in response to high vs. low energy-dense food cues in obese humans: An fMRI study

Effect of preterm birth and birth weight on eating behavior at 2 y of age

Sex differences in the physiology of eating

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