Sex-based difference in immune responses and efficacy of the pneumococcal conjugate vaccine
Essi Y. I. Tchalla,
Anagha Betadpur,
Andrew Y. Khalil
et al.
Abstract:Vaccine-mediated protection and susceptibility to Streptococcus pneumoniae (pneumococcus) infections are influenced by biological sex. The incidence of invasive pneumococcal disease remains higher in males compared to females even after the introduction of the pneumococcal conjugate vaccine (PCV). However, sex-based differences in the immune response to this conjugate vaccine remain unexplored. To investigate those differences, we vaccinated adult male and female mice with PCV and assessed cellular and humoral… Show more
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