Sex-autosome translocations: meiotic behaviour suggests an inactivation block with permanence of autosomal gene activity in Phyllostomid bats

Noronha, Renata Coelho Rodrigues; Nagamachi, Cleusa Yoshiko; Pieczarka, Júlio César; Marques-Aguiar, Suely Aparecida; Barros, Regina Maria de Souza

doi:10.1080/00087114.2001.10589235

Cited by 11 publications

(14 citation statements)

References 10 publications

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“…To account for the fixation of these chromosomal rearrangements, several authors [for a review, see Dobigny et al, 2004] have proposed that accumulation of heterochromatin between the sex and autosomal segments may serve to insulate the 2 chromosomal arms, thus reducing the disruptive effects of these types of rearrangements. Support for this hypothesis is found in almost all mammal species known to possess sex-autosome fusions, in which a large block of heterochromatin is identified between the autosome and the X chromosome segments [e.g., Ratomponirina et al, 1986;Jaafar et al, 1993;Yang et al, 1997;Metcalfe et al, 1998;Rodrigues Noronha et al, 2001;Dobigny et al, 2004;Deuve et al, 2008]. However, concerning the African pygmy mice, while results for M .…”

mentioning

confidence: 81%

“…This suggests that inherent genomic traits allowing a higher rate of occurrence and/or fixation of this rearrangement may be present within the Nannomys . In other mammal species with sex-autosome fusions, a large block of heterochromatin is almost systematically present between the autosome and the X chromosome components [e.g., Ratomponirina et al, 1986;Jaafar et al, 1993;Yang et al, 1997;Metcalfe et al, 1998;Rodrigues Noronha et al, 2001;Dobigny et al, 2004;Deuve et al, 2008]. It has thus been proposed that such a heterochromatic block has been selected to functionally isolate the original X and the translocated autosome.…”

Section: Role Of Its As a Buffer Between Autosomal And Sex Chromosomementioning

confidence: 99%

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Extensive Amplification of Telomeric Repeats in the Karyotypically Highly Diverse African Pygmy Mice

Colomina¹,

Catalan²,

Britton‐Davidian³

et al. 2017

Cytogenet Genome Res

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Telomeres are ribonucleoprotein structures protecting the physical ends of eukaryotic chromosomes. However, telomeric sequences can also occur at non-terminal regions of chromosomes, forming the so-called interstitial telomeric sequences (ITSs). Some ITSs are considered as relics of past chromosomal rearrangements and as such provide important insights into karyotype evolution. By FISH, we explored the distribution of telomeric motifs in the genome of a complex of mammalian species that has long been recognized for its extraordinary karyotypic diversity: the African pygmy mice. This survey involved 5 species, representing 10 highly diverse karyotypes with or without autosomal and sex-autosome robertsonian (Rb) fusions. The study revealed that in species with an ancestral-like karyotype (i.e., no fusions; Mus mattheyi and M. indutus), only terminal telomeres were observed, whereas in species experiencing intense chromosomal evolution (e.g., M. minutoides, M. musculoides), a large amplification of telomeric repeats was also identified in the pericentromeric region of acrocentrics and most metacentrics. We concluded that (i) the mechanism of Rb fusion in the African pygmy mice is different than the one highlighted in the house mouse; (ii) the intensity of the ITS hybridization signal could be a signature of the age of formation of the Rb fusion; (iii) the large amplification of pericentromeric telomeric sequences in acrocentrics may mediate the formation of Rb fusions, and (iv) the ITSs on the sex-autosome fusion Rb(X.1) may participate to the insulation buffer between the sexual and autosomal arms to prevent X inactivation from spreading and silencing autosomal genes and allow the independent regulation of replication timing of both segments.

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mentioning

confidence: 81%

Section: Role Of Its As a Buffer Between Autosomal And Sex Chromosomementioning

confidence: 99%

Extensive Amplification of Telomeric Repeats in the Karyotypically Highly Diverse African Pygmy Mice

Colomina¹,

Catalan²,

Britton‐Davidian³

et al. 2017

Cytogenet Genome Res

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“…Most of the species in subfamily Glossophaginae, including Glossophaga soricina, have a classical (XY) chromosomal sex determination system, whereas the species in subfamily Stenodermatinae have XY 1 Y 2 multiple and neo-XY compound systems (Baker and Hsu 1970;Solari 1994;Noronha et al 2001). The sex compound chromosomes of Stenodermatinae are the result of two successive chromosome rearrangements, but the autosome involved in these rearrangements has not been identified (Tucker 1986;Rodrigues et al 2005).…”

Section: Introductionmentioning

confidence: 97%

“…There are species with a compound (neo-XX/XY) sex determination system which presents a typical XY body, as in the house musk shrew Suncus murinus and some bats (Solari 1994;Noronha et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Meiotic analysis of XX/XY and neo-XX/XY sex chromosomes in Phyllostomidae by cross-species chromosome painting revealing a common chromosome 15-XY rearrangement in Stenodermatinae

et al. 2010

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We analyzed the meiotic behavior of the sex chromosomes of the bats Glossophaga soricina (XX/XY), Artibeus cinereus and Uroderma magnirostrum (neo-XX/XY) using multicolor FISH. The X chromosome and pair 15 autosome probes are from Phyllostomus hastatus and the Y from Carollia brevicauda. On both species with the neo-XX/XY system, the autosome translocated to the sex chromosomes is the pair 15 in P. hastatus, a synapomorphy. The analysis of meiosis confirms that the X and Y have a pseudo-autosomal region, with a typical end-to-end pairing. The autosomal regions of the neo-XX/XY shows different levels of condensation when compared to the original XX/XY. The compound system presented a characteristic shape, as if it was a closed ring with a tail. The ring represents the non-paired segments of the X and Y and the small pairing region of the original sex chromosomes. The tail corresponds to the pairing of the 15 P. hastatus autosomal bivalent, which are translocated to the sex chromosomes. Probably the non-pairing is responsible for the meiotic silencing of these segments.

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“…3 g). Studies in some mammals that have an X-autosome translocation show that the original X is separated from the autosomal sequence by a heterochromatic block (Kasahara and Dutrillaux, 1983;Noronha et al, 2001;Dobigny et al, 2004). This block probably does not allow the spreading of X inactivation to the autosomal segment of the X during meiosis (Solari and Pigozzi, 1994;Noronha et al, 2001).…”

Section: Xy 1 Y 2 Meiosis: Fish Analysismentioning

confidence: 99%

Neo-XY body: an analysis of XY1Y2 meiotic behavior in Carollia (Chiroptera, Phyllostomidae) by chromosome painting

Noronha

Nagamachi

O’Brien

et al. 2009

Cytogenet Genome Res

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Classical and molecular cytogenetic analyses of mitotic and meiotic cells were performed on two species of Carollia from the family Phyllostomidae (Chiroptera), which have an XX/XY₁Y₂ sex determination system. Our results show that the species Carollia perspicillata and Carollia brevicauda have the same Xq-autosome translocation (neo-X). Using multicolor FISH we observed different levels of condensation of the original X and Y chromosomes when compared to the translocated autosomal segment, a likely consequence of the nucleolar organizer region blocking spreading of inactivation to the autosomal region of the neo-X. The use of chromosome painting showed the behavior of the sex chromosome trivalent – here called the ‘neo-XY body’ – in meiosis. We compared the variation between the condensation of the original X and Y and the autosome-sex chromosome axis and described the pairing between the original X-Y segments (pseudoautosomal region) and the XY₂ homologous segments, suggesting genetic activity of the latter during meiosis.

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Sex-autosome translocations: meiotic behaviour suggests an inactivation block with permanence of autosomal gene activity in Phyllostomid bats

Cited by 11 publications

References 10 publications

Extensive Amplification of Telomeric Repeats in the Karyotypically Highly Diverse African Pygmy Mice

Extensive Amplification of Telomeric Repeats in the Karyotypically Highly Diverse African Pygmy Mice

Meiotic analysis of XX/XY and neo-XX/XY sex chromosomes in Phyllostomidae by cross-species chromosome painting revealing a common chromosome 15-XY rearrangement in Stenodermatinae

Neo-XY body: an analysis of XY<sub>1</sub>Y<sub>2</sub> meiotic behavior in <i>Carollia</i> (Chiroptera, Phyllostomidae) by chromosome painting

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