Sex and rheumatoid arthritis: Mouse model versus human disease

Cutolo, Maurizio

doi:10.1002/art.22322

Cited by 28 publications

(24 citation statements)

References 16 publications

(8 reference statements)

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“…This outcome might be concerned with large variation in age at menopause in both case and control groups. Several investigations have described that estrogen may increase the risk of RA through promoting phagocytic activity of immune system and producing antibodies (8,9). In addition, it is revealed that the balance among sex hormones impaired in synovial fluid of subjects with RA (9).…”

Section: Discussionmentioning

confidence: 99%

“…Several investigations have described that estrogen may increase the risk of RA through promoting phagocytic activity of immune system and producing antibodies (8,9). In addition, it is revealed that the balance among sex hormones impaired in synovial fluid of subjects with RA (9). It seems that estrogen to androgen ratio is increasing in favor of exacerbating inflammatory condition (1,34).…”

Section: Discussionmentioning

confidence: 99%

“…The contributions of high estrogen level to the hypothalamic-pituitary-adrenal (HPA) axis in augmentation of inflammatory reactions were addressed in different earlier observations (7). Additionally, estrogen is likely attributed to the upregulated production of auto-antibodies such as rheumatoid factor (RF) and anticyclic citrullinated peptides (anti-CCP) (8,9), suggesting a possible promoting effect of estrogen on RA development. In other circumstances, a series of epidemiologic data re- cently suggested the protective role of high level of estrogen on RA pathogenesis prominently resulted from the significant ameliorating conditions in association with pregnancy and post-partum flares on RA symptoms (10).…”

Section: Introductionmentioning

confidence: 99%

“…In other circumstances, a series of epidemiologic data re- cently suggested the protective role of high level of estrogen on RA pathogenesis prominently resulted from the significant ameliorating conditions in association with pregnancy and post-partum flares on RA symptoms (10). It is biologically speculated that estrogen might be attributed to the inhibition of IL-1 and TNF-α secretions from macrophage and T-cells and also induction of regulatory T-cells and TGF-β, which altogether results in osteoclast apoptosis and reduction in inflammation and eventually might lead to remission in the disease (8,9). There is confined evidence with contradictory findings to support the role of estrogen and related reproductive factors (such as age at menarche, age at menopause and age at first delivery) in RA risk, which is subject to a debate.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study

Shishavan

Pirouzpanah

Hajialilo

et al. 2016

Iran Red Crescent Med J

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Background: Given the high prevalence of rheumatoid arthritis (RA) in females of reproductive ages, it seems that hormonal factors might be important in RA pathogenesis. Objectives: The current study aimed to investigate the association between females' reproductive factors occurring prior to the onset of rheumatoid arthritis and the risk of RA development. Methods: This case-control study was conducted on 231 patients with RA and 238 controls among females aged 26 -64 years old from the North-West of Iran. The adjusted risk of RA was assessed using multivariate logistic regression models.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study

Shishavan

Pirouzpanah

Hajialilo

et al. 2016

Iran Red Crescent Med J

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“…ERs have prominent effects on immune function in both the innate and adaptive immune responses. However, the roles of estrogen receptors may be different between species, significantly limiting the easy translation of preclinical studies (in animal models) into the clinical setting (6).…”

mentioning

confidence: 99%

Selective estrogen receptor agonism lacks clinical benefit in rheumatoid arthritis: Comment on the article by van Vollenhoven et al

Cutolo

2010

Arthritis & Rheumatism

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study of cartilage defects, measured using GRE-type sequences, are valid. Furthermore, this discussion has highlighted that in both clinical medicine and epidemiology studies there is often more than one way by which to measure a structure or feature, so it is critical that investigators and readers consider the epidemiologic issues around measurement integrity when interpreting study findings. We politely suggest that, based on the current evidence, there should not be any specific recommendations in regard to the best MRI protocol for obtaining images from which cartilage defects can be scored in population-based studies.

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Efficacy and safety of a selective estrogen receptor β agonist, ERB‐041, in patients with rheumatoid arthritis: A 12‐week, randomized, placebo‐controlled, phase II study

Roman‐Blas¹,

Castañeda²,

Cutolo³

et al. 2010

Arthritis Care & Research

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Results. No statistically significant difference for the ACR20 was found between the ERB-041 treatment and placebo groups (P ‫؍‬ 0.518). Nor was a significant difference observed for ACR50 and ACR70 responses, health outcomes measures, CRP levels, and overall incidence of adverse events among all groups. Forty-four subjects (15.1%) discontinued the study and the rate of discontinuation was similar among the treatment groups. The most commonly reported treatment-emergent adverse events were headache (7.6%), nausea (6.2%), infection (4.8%), and bronchitis (4.1%). None of the adverse events was considered treatment related. Conclusion. Although well tolerated and safe, ERB-041 failed to demonstrate antiinflammatory efficacy in RA patients, despite evidence of strong activity in preclinical arthritis models. These results suggest that selective ER␤ agonists would not have effects on regulating inflammatory response in RA. Nevertheless, further studies are warranted to establish their efficacy in inflammatory arthritis.

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Sex and rheumatoid arthritis: Mouse model versus human disease

Cited by 28 publications

References 16 publications

Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study

Risk Factors of Rheumatoid Arthritis Development Among Females in North-West of Iran: A Case-Control Study

Selective estrogen receptor agonism lacks clinical benefit in rheumatoid arthritis: Comment on the article by van Vollenhoven et al

Efficacy and safety of a selective estrogen receptor β agonist, ERB‐041, in patients with rheumatoid arthritis: A 12‐week, randomized, placebo‐controlled, phase II study

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