Sex and APOE4-specific links between cardiometabolic risk factors and white matter alterations in individuals with a family history of Alzheimer’s disease
Stefanie A. Tremblay,
R. Nathan Spreng,
Alfie Wearn
et al.
Abstract:INTRODUCTION: White matter (WM) alterations are among the earliest changes in Alzheimer's disease (AD), yet limited work has comprehensively characterized the effects of AD risk factors on WM. METHODS: In older adults with a family history of AD, we investigated the sex-specific and APOE genotype-related relationships between WM microstructure and risk factors. Multiple MRI-derived metrics were integrated using a multivariate approach based on the Mahalanobis distance (D2). The links between WM D2 and cognitio… Show more
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