Sex and allergic diseases

Nowak‐Węgrzyn, Anna; Ellis, Anne K.; Castells, Mariana

doi:10.1016/j.anai.2018.12.010

Cited by 10 publications

(9 citation statements)

References 7 publications

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“…Males and females probably have different evolutionary needs, so the former have a more efficient humoral based response, whereas the latter show an immune response less efficient upon pathogen challenge [4]. Evidences indicate that progesterone, androgens, and glucocorticoids may have an immunosuppressive effect, whereas estrogens enhance mast cell reactivity, delayed type IV allergic reactions, humoral responses, and autoimmunity [7,8]. The male (testosterone) and female sex hormones (estrogen and progesterone) binding to the receptors expressed on the surface of a moltitude of cells types activate signaling cascade or directly induce gene expression [9].…”

Section: Hormones Chromosomes Immunity and Allergymentioning

confidence: 99%

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

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Allergies are rapidly worsening in recent decades, representing the most common immunological diseases. The mechanism of disorders such as asthma, rhinocongiuntivitis, urticaria, atopic dermatitis, food and drug allergies, and anaphylaxis still remain unclear and consequently treatments is mostly still symptomatic and aspecific while developments of new therapies are limited. A growing amount of data in the literature shows us how the prevalence of allergic diseases is different in both sexes and its changes over the course of life. Genes, hormones, environmental and immunological factors affect sex disparities associated with the development and control of allergic diseases, while they more rarely are considered and reported regarding their differences related to social, psychological, cultural, economic, and employment aspects. This review describes the available knowledge on the role of sex and gender in allergies in an attempt to improve the indispensable gender perspective whose potential is still underestimated while it represents a significant turning point in research and the clinic. It will offer insights to stimulate exploration of the many aspects still unknown in this relationship that could ameliorate the preventive, diagnostic, and therapeutic strategies in allergic diseases.

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Section: Hormones Chromosomes Immunity and Allergymentioning

confidence: 99%

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Martinis

Sirufo

Suppa

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…This gender-specific trend suggests the 'adolescent switch' discussed in other studies. Asthma mostly affects boys in childhood and women in adulthood [20], with many factors contributing to its frequency and severity, including shift in sex hormone [21][22][23], genetic factors [24], maternal asthma [25], and environmental exposure [26]. Gender-specific trend for asthma should be taken into account in asthma management and it is relevant to consider gender differences in the daily clinical practice [27].…”

Section: Discussionmentioning

confidence: 99%

Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study

et al. 2020

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Background: Respiratory infections are one of three leading causes of childhood mortality, and worldwide increase and recent plateau in childhood asthma has been reported. However, data on trends of respiratory diseases over long period of time is limited. This study aimed to determine the trends of respiratory disease outpatient visits (ROVs) and diagnoses (RODs) in one of the largest children's teaching hospitals in China between 2009 and 2018. Methods: A retrospective study based on routine administrative data was designed and implemented according to the RECORD statement. Demographic details and diagnoses of the outpatients < 18 years visiting the respiratory department of the hospital were extracted from the Hospital Information System. Age-and gender-specific trends were illustrated by calculating average annual growth rate (AAGR) for ROVs and comparing change of proportion for different RODs over time. Results: There were 698,054 ROVs from 285,574 children (40.4% female). AAGR of ROVs was 15.2%. Children aged 4 to < 7 years had a faster increase than other age groups. Bronchitis (27.6%), pneumonia (18.5%), pneumonia affecting other systems (18.4%), asthma and status asthmaticus (10.7%), and vasomotor and allergic rhinitis (9.2%) accounted for 84.4% of all RODs. The proportion of bronchitis decreased across years, with the concomitant increasing trend in the proportion of pneumonia. Age-specific trend in diagnoses showed greater proportion of asthma in all visits for the children aged 7 to < 18 years than younger children. Gender-specific trend in diagnoses showed the proportion of asthma was greater for males but the AAGR was greater for females. Conclusion: The persistent upward trend in ROVs was observed among children at different ages and a gender difference was also seen. In contrast to what has been reported, burden of asthma and allergies diseases continues to increase locally.

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“…This gender-specific trend suggests the 'adolescent switch' discussed in other studies. Asthma mostly affects boys in childhood and women in adulthood [20], with many factors contributing to its frequency and severity, including shift in sex hormone [21][22][23], genetic factors [24], maternal asthma [25], and environmental exposure [26]. Genderspecific trend for asthma should be taken into account in asthma management and it is relevant to consider gender differences in the daily clinical practice [27].…”

Section: Discussionmentioning

confidence: 99%

Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study

Shi

Zhang

Liu

et al. 2020

Preprint

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Background: Respiratory infections are one of three leading causes of childhood mortality, and worldwide increase and recent plateau in childhood asthma has been reported. However, data on trends of respiratory diseases over long period of time is limited. This study aimed to determine the trends of respiratory disease outpatient visits (ROVs) and diagnoses (RODs) in one of the largest children’s teaching hospitals in China between 2009 and 2018. Methods: A retrospective study based on routine administrative data was designed and implemented according to the RECORD statement. Demographic details and diagnoses of the outpatients <18 years visiting the respiratory department of the hospital were extracted from the Hospital Information System. Age- and gender-specific trends were illustrated by calculating average annual growth rate (AAGR) for ROVs and comparing change of proportion for different RODs over time. Results: There were 698054 ROVs from 285574 children (40.4% female). AAGR of ROVs was 15.2%. Children aged 4 to < 7 years had a faster increase than other age groups. Bronchitis (27.6%), pneumonia (18.5%), pneumonia affecting other systems (18.4%), asthma and status asthmaticus (10.7%), and vasomotor and allergic rhinitis (9.2%) accounted for 84.4% of all RODs. The proportion of bronchitis decreased across years, with the concomitant increasing trend in the proportion of pneumonia. Age-specific trend in diagnoses showed greater proportion of asthma in all visits for the children aged 7 to < 18 years than younger children. Gender-specific trend in diagnoses showed the proportion of asthma was greater for males but the AAGR was greater for females. Conclusion: The persistent upward trend in ROVs was observed among children at different ages and a gender difference was also seen. In contrast to what has been reported, burden of asthma and allergies diseases continues to increase locally.

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Sex and allergic diseases

Cited by 10 publications

References 7 publications

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Sex and Gender Aspects for Patient Stratification in Allergy Prevention and Treatment

Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study

Age- and gender-specific trends in respiratory outpatient visits and diagnoses at a tertiary pediatric hospital in China: a 10-year retrospective study

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