Sex and age discrepancy of <scp>HbA1c</scp> and fetal hemoglobin determined by <scp>HPLC</scp> in a large Chinese Han population

Hu, Jihong; Gao, Jun; Li, Jianbo

doi:10.1111/1753-0407.12544

Cited by 10 publications

(4 citation statements)

References 52 publications

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“…Additionally, an early Hb level, as with the other blood lines, is very dependent on weeks and increases with weeks [24,25]. This explains the results of our decision tree, i.e., an early Hb threshold of >15.2 would have no independent impact at 24 months on a population that is said to be less at risk (female, VP, >26 weeks), which naturally has a higher sex-related Hb fetal threshold [26]. A recent study confirms this sex-specific association between an early marker of anemia and cognitive function at age 12 months of age and white matter volume [27].…”

Section: Discussionmentioning

confidence: 63%

Impact of Early Hemoglobin Levels on Neurodevelopment Outcomes of Two-Year-Olds in Very Preterm Children

et al. 2023

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Objective: To evaluate, in very preterm infants, the hemoglobin (Hb) levels during the first 24 h and the neurodevelopment outcomes at 24 months of corrected age. Design, setting, and patients: We conducted a secondary analysis of the French national prospective and population-based cohort EPIPAGE-2. The eligible study participants were live-born singletons who were born before 32 weeks of gestational age, with early Hb levels who were admitted to the neonatal intensive care unit. Main outcome measures: The early Hb levels for an outcome survival at 24 months of corrected age without neurodevelopmental impairment were measured. The secondary outcomes were survival at discharge and without severe neonatal morbidity. Results: Of the 2158 singletons of <32 weeks with mean early Hb levels of 15.4 (±2.4) g/dL, 1490 of the infants (69%) had a follow-up at two years of age. An early Hb of 15.2 g/dL is the minimum receiving operating characteristic curve at the 24 months risk-free level, but the area under the curve at 0.54 (close to 50%) indicates that this rate was not informative. In logistic regression, no association was found between early Hb levels and outcomes at two years of age (aOR 0.966; 95% CI [0.775–1.204]; p = 0.758) but rather there was a correlation found with severe morbidity (aOR 1.322; 95% CI [1.003–1.743]; p = 0.048). A risk stratification tree showed that male newborns of >26 weeks with Hb of <15.5 g/dL (n = 703) were associated with a poor outcome at 24 months (OR 1.9; CI: [1.5–2.4] p < 0.01). Conclusions: Early low Hb levels are associated with major neonatal morbidities in VP singletons, but not with neurodevelopment outcomes at two years of age, except in male infants of >26 Weeks GA.

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Section: Discussionmentioning

confidence: 63%

Impact of Early Hemoglobin Levels on Neurodevelopment Outcomes of Two-Year-Olds in Very Preterm Children

et al. 2023

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“…A series of studies have also indicated that VI or low visual acuity is more prevalent among Chinese women (general population) ( 28 ). Studies showed that women might have a longer life expectancy, higher HbA1c level ( 29 ), and higher prevalence of DM ( 30 ) than men, which may contribute to their higher risk of developing DM-related ocular complications and age-related ocular disorders ( 22 ). However, whether DM and gender could synergistically affect VI in the Chinese population with DM is yet to be elucidated and deserves further studies.…”

Section: Discussionmentioning

confidence: 99%

The prevalence, incidence, and persistence of self-reported visual impairment among Chinese population with diabetes mellitus: evaluation from a nationally representative survey, 2015–2018

Zhou

Jin

Wang

et al. 2023

Front. Public Health

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AimsOur aim was to investigate the prevalence, incidence, and persistence of visual impairment (VI) and their correlates among the Chinese population with diabetes mellitus (DM) over 3 years.Materials and methodsThe China Health and Retirement Longitudinal Survey is the first nationally representative longitudinal survey of the Chinese population. A cross-sectional analysis of prevalent VI in 2015 consisted of 2,173 participants with DM. A longitudinal observation of incident and persistent VI consisted of 1,633 participants from 2015 to 2018. Risk factors of VI were identified via univariate and multivariate logistic regression analyses.ResultsAmong our study population with DM, 11.8% reported VI in 2015, 4.5% had persistent VI from 2015 to 2018, and 8.9% developed VI in 2018. Factors identified to be correlated to VI (p < 0.05) were older age, being a woman, lower educational attainment, living in a rural area, application of DM medication and non-pharmacological treatment, receiving DM-related tests, use of spectacles, and poorer health status.ConclusionThis most recent national data provides a baseline for future public health initiatives on VI among the Chinese population with DM. With multiple risk factors identified, these could provide concurrent targets for various public health strategies and interventions with the aim of reducing the burden of VI among the population with DM in China.

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“…Thus, this study uniquely establishes the existence of a strong association between HbA1c, HbA0 and HbA2, which should be explored further to determine possible interference in HbA1c estimation, especially among populations with prevalently higher proportions of the highlighted Hb types. In contrast, another study targeting age-speci c effects of Hb types on HbA1c interpretation reported a rather low degree of correlation between HbF and Hba1c, suggesting that age could be a signi cant factor in the interpretation of HbA1c levels (Hu et al, 2018). Since the analysis was done across patients with various ages with varying glycaemic control capabilities (both types 1 and 2 diabetes mellitus), this could explain the deviation from the ndings of the current study, which only focused on patients with T2DM, which are primarily of adult age.…”

Section: Discussionmentioning

confidence: 90%

Haemoglobin types and variant interference with HbA1c and its association with uncontrolled HbA1c in type 2 diabetes mellitus

Malaba,

Kosiyo,

Guyah

2024

Preprint

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Diabetes mellitus is among the leading global health concerns, causing over 1.5 million deaths alongside other significant comorbidities and complications. Conventional diagnosis involves estimating fasting, random blood glucose levels and glucose tolerance test. For monitoring purposes, long-term glycaemic control has been achieved through the measurement of glycated haemoglobin (HbA1c) which is considered reliable and preferred tool. However, its estimation could be affected by haemoglobin types like HbA0, HbA2, and HbF concentrations whose magnitude remains unclear as well as other haematological parameters. As such, the current study determined the association between HbA1c and haemoglobin types and determined correlation between haemoglobin types and haematological parameters among patients with type 2 diabetes mellitus (T2DM) compared to healthy non-diabetic participants. In this cross-sectional study, participants [n = 144 (72 per group), ages 23-80 years] at the Bungoma County Referral Hospital were recruited using simple random sampling. HbA1c and other Haemoglobin variants were measured using ion-exchange high-performance liquid chromatography (HPLC) by the Bio-Rad D-10 machine (Bio-Rad Laboratories, Inc). Haematological parameters were measured using the Celtac G MEK-9100K machine (Nihon Kohden Europe). Chi-square (c2) analysis was used to determine the differences between proportions. Mann-Whitney U test was used to compare laboratory characteristics between (T2DM) patients and non-diabetics. With HbA0 as the reference group, association between HbA1c and haemoglobin types was determined using multivariate logistic regression. Correlation between haemoglobin types and haematological parameters was determined using Pearson correlation. HbA1c is associated with reduced HbA0 [OR=0.949, 95% CI=0.914-0.986, p=0.007], reduced HbA2 [OR=0.275, 95% CI=0.146-0.489, p=0.001] and reduced HbF [OR=0.322, 95% CI=0.140-0.745, p=0.008]. Further, HCT had a negative correlation with HbAO and a positive correlation with HbAS in participants with controlled diabetes. MCV and MCH had a negative correlation with HbF. The MCH had a negative correlation with HbA2 in participant with uncontrolled diabetes. The study concluded that HbA1c is significantly associated with reduced haemoglobin types (HbA0, HbA2, HbSS, and HbF) in type 2 diabetes mellitus hence levels of various haemobglobin types should be considered in monitoring glycaemic control.

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Sex and age discrepancy of HbA1c and fetal hemoglobin determined by HPLC in a large Chinese Han population

Abstract: The data suggest that sex and age should be considered in clinical interpretation of HbA1c.

Cited by 10 publications

References 52 publications

Impact of Early Hemoglobin Levels on Neurodevelopment Outcomes of Two-Year-Olds in Very Preterm Children

Impact of Early Hemoglobin Levels on Neurodevelopment Outcomes of Two-Year-Olds in Very Preterm Children

The prevalence, incidence, and persistence of self-reported visual impairment among Chinese population with diabetes mellitus: evaluation from a nationally representative survey, 2015–2018

Haemoglobin types and variant interference with HbA1c and its association with uncontrolled HbA1c in type 2 diabetes mellitus

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