Sex- and age-dependent contribution of System xc– to cognitive, sensory, and social behaviors revealed by comprehensive behavioral analyses of System xc– null mice
Abstract:BackgroundSystem xc– (Sxc–) is an important heteromeric amino acid cystine/glutamate exchanger that plays a pivotal role in the CNS by importing cystine into cells while exporting glutamate. Although certain behaviors have been identified as altered in Sxc– null mutant mice, our understanding of the comprehensive impact of Sxc– on behavior remains incomplete.MethodsTo address this gap, we compared motor, sensory and social behaviors of male and female mice in mice null for Sxc– (SLC7A11sut/sut) with wildtype l… Show more
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