Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry

Sugianto, Rizky Indrameikha; Schmidt, Bernhard M.W.; Memaran, Nima; Düzova, Ali; Topaloğlu, Rezan; Seeman, Tomáš; König, Sabine; Strologo, Luca Dello; Murer, Luisa; Özçakar, Z. Bı̇rsı̇n; Bald, Martin; Shenoy, Mohan; Buescher, Anja; Hoyer, Peter F.; Pohl, Michael; Billing, Heiko; Oh, Jun; Staude, Hagen; Pöhl, Martin; Genç, Gürkan; Klaus, Günter; Alparslan, Caner; Grenda, Ryszard; Rubik, Jacek; Krupka, Kai; Tönshoff, Burkhard; Wühl, Elke

doi:10.1007/s00467-019-04395-4

Cited by 20 publications

(18 citation statements)

References 42 publications

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“…In the pediatric population, girls are less likely to undergo pre-emptive transplantation 6,22 and show poorer graft survival than boys, the latter being partly explained by receiving male donor organs 23,24 . Our own data indicated a greater susceptibility of girls for cyclosporin A-associated hypertension 25 , which could contribute to poorer graft survival and increased cardiovascular mortality.…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 71%

“…Notably, we previously showed that girls are more susceptible to cyclosporine Aassociated hypertension than boys 25 .…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 94%

“…The observed association between higher BP and higher PWV in both sexes is in accordance with previous findings in the general pediatric population 60,61 , in various patient groups 15,17,62 and after kidney transplantation 18,63 . Uncontrolled or untreated hypertension is present in 30-40% of pediatric kidney allograft recipients 25,63 .…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

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Findings from 4C-T Study demonstrate an increased cardiovascular burden in girls with end stage kidney disease and kidney transplantation

Sugianto

Memaran

Schmidt

et al. 2022

Kidney International

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Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 71%

“…Notably, we previously showed that girls are more susceptible to cyclosporine Aassociated hypertension than boys 25 .…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 94%

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

See 1 more Smart Citation

Findings from 4C-T Study demonstrate an increased cardiovascular burden in girls with end stage kidney disease and kidney transplantation

Sugianto

Memaran

Schmidt

et al. 2022

Kidney International

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“…Our findings in these otherwise healthy but overweight children are in accordance with data from a large cohort of children with chronic kidney disease, in whom a stronger association of obesity with LVMIz and LVH was demonstrated among girls compared to boys [ 7 ]. A greater vulnerability of girls upon cardiovascular stresses had been demonstrated in older girls after renal transplantation that displayed higher BP values when exposed to an additional risk, i.e., higher trough levels for cyclosporine A [ 25 ]. Further support comes from recent adult data.…”

Section: Discussionmentioning

confidence: 99%

Impact of Sex and Obesity on Echocardiographic Parameters in Children and Adolescents

et al. 2022

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Subclinical alterations in left ventricular structure and function are detectable in adolescents with hypertension or obesity. However, data on early echocardiographic abnormalities in seemingly healthy children are lacking. Sex differences in cardiac structure and function have been previously reported, but sex-specific reference values are not available. Specifically, the potential interaction of sex and overweight has not been addressed at all. Anthropometric data, blood pressure and exercise tests were obtained in 356 healthy children. Echocardiographic parameters comprised peak early (E) and late (A) mitral inflow Doppler velocities, E/A ratio, tissue Doppler peak velocities of early (e′) and late diastolic (a′) excursion of mitral/septal annulus and isovolumetric relaxation time (IVRT). Left ventricular mass index (LVMI) and LVMI z-score were calculated. Interaction terms between BMI and sex and stratification by sex were used for analysis. We provide values for echocardiographic parameters for children of two age groups separated by BMI. Overweight/obese children had a significant higher LVMI, lower E/A ratio, higher E/e′ ratios and a longer IVRT. For a given BMI in the upper ranges we demonstrated a higher LVMI in girls than in boys, the IVRT extended significantly more in girls than in boys with increasing BMI. There are sex differences in structural and functional echocardiographic parameters in children and adolescents. Our data not only confirms the importance of overweight and obesity, but demonstrates important interactions between sex and overweight. The greater susceptibility of overweight girls toward echocardiographic changes associated with potential long-term functional impairment needs further exploration and follow-up.Trial registration number DRKS00012371; Date 18.08.2017.

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“…The dependent variable was a binary variable indicating whether a resident suffered from hypertension. Hypertension is defined in accordance with the national guidelines for primary hypertension prevention and management [ 29 , 30 ]: currently taking antihypertensive drugs, previously diagnosed as hypertensive by a clinician, or systolic blood pressure over 140 mm Hg or diastolic blood pressure over 90 mm Hg without antihypertensive drugs.…”

Section: Methodsmentioning

confidence: 99%

The Association of Midday Napping With Hypertension Among Chinese Adults Older Than 45 Years: Cross-sectional Study

Tang

Zhou

Long

et al. 2022

JMIR Public Health Surveill

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Background Hypertension is one of the main public health issues around worldwide, and midday napping is a popular habit. The association between the two remains to be explored. Objective The goal of the research was to explore the association of midday napping with hypertension. Methods This study separately selected 11,439, 12,689, and 9464 Chinese respondents aged over 45 years from the China Health and Retirement Longitudinal Study 2011, 2015, and 2018 data sets. Binary logistic regression was used to explore the association of midday napping with hypertension, and the 3-step method was used to test the mediation effect of BMI. Results Among all respondents, the prevalence rates of hypertension were 24.6% (2818/11439) in 2011, 21.1% (2683/12689) in 2015, and 22.1% (2092/9464) in 2018. Midday napping was positively correlated with hypertension. In 2011 and 2015, napping 60 to 90 minutes had the greatest odds ratios [OR] (OR2011 1.705, OR2015 1.494). In 2018, the biggest OR came from the group napping 30 to 60 minutes (OR 1.223), and ORs of different napping durations decreased from 2011 to 2018. In addition, BMI had a partial mediation effect in 2015 and 2018. Conclusions Midday napping is a potential risk factor for hypertension with BMI acting as a mediator. To prevent hypertension, avoiding prolonged duration of midday napping and taking action to maintain a normal BMI level are recommended.

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Sex and age as determinants for high blood pressure in pediatric renal transplant recipients: a longitudinal analysis of the CERTAIN Registry

Cited by 20 publications

References 42 publications

Findings from 4C-T Study demonstrate an increased cardiovascular burden in girls with end stage kidney disease and kidney transplantation

Findings from 4C-T Study demonstrate an increased cardiovascular burden in girls with end stage kidney disease and kidney transplantation

Impact of Sex and Obesity on Echocardiographic Parameters in Children and Adolescents

The Association of Midday Napping With Hypertension Among Chinese Adults Older Than 45 Years: Cross-sectional Study

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