Sex-, Age-, and Ethnicity-Dependent Variation in Body Composition: Can There Be a Single Cutoff?

González, Marı́a Cristina; Xiao, Jingjie; Disi, Ilana Roitman

doi:10.1007/978-3-030-26226-6_8

Cited by 1 publication

(1 citation statement)

References 29 publications

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“…Computed tomography body composition reference values matched well-established patterns of body habitus with increased aging ( 1 , 12 , 31 ): women had higher subcutaneous adipose tissue area, whereas men had higher visceral adipose tissue area, higher skeletal muscle area, and higher skeletal muscle density. Our data show that vertebral bone area increased with older age, but that vertebral bone density decreased with older age.…”

Section: Discussionsupporting

confidence: 61%

Abdominal Body Composition Reference Ranges and Association With Chronic Conditions in an Age- and Sex-Stratified Representative Sample of a Geographically Defined American Population

Weston,

Grossardt,

Garner

et al. 2024

The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences

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Background Body composition can be accurately quantified from abdominal CT exams and is a predictor for the development of aging-related conditions and for mortality. However, reference ranges for CT-derived body composition measures of obesity, sarcopenia, and bone loss have yet to be defined in the general population. Methods We identified a population-representative sample of 4,900 persons aged 20 to 89 years who underwent an abdominal CT exam from 2010 to 2020. The sample was constructed using propensity score matching to an age and sex stratified sample of persons residing in the 27-county region of Southern Minnesota and Western Wisconsin. The matching included race, ethnicity, education level, region of residence and the presence of 20 chronic conditions. We used a validated deep learning based algorithm to calculate subcutaneous adipose tissue area, visceral adipose tissue area, skeletal muscle area, skeletal muscle density, vertebral bone area, and vertebral bone density from a CT abdominal section. Results We report CT-based body composition reference ranges on 4,649 persons representative of our geographic region. Older age was associated with a decrease in skeletal muscle area and density, and an increase in visceral adiposity. All chronic conditions were associated with a statistically significant difference in at least one body composition biomarker. The presence of a chronic condition was generally associated with greater subcutaneous and visceral adiposity, and lower muscle density and vertebrae bone density. Conclusions We report reference ranges for CT-based body composition biomarkers in a population-representative cohort of 4,649 persons by age, sex, body mass index, and chronic conditions.

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Section: Discussionsupporting

confidence: 61%