Sevoflurane Relieves Lung Function Deterioration After Cardiopulmonary Bypass

Balogh, Á.; Peták, Ferenc; Fodor, Gergely H.; Südy, Roberta; Babik, Barna

doi:10.1053/j.jvca.2017.02.186

Cited by 10 publications

(17 citation statements)

References 34 publications

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“…Non-physiological blood circulation causes systemic inflammatory response syndrome during CPB ( 33 ). Furthermore, organ ischemia-reperfusion injury and surgical trauma are also important triggering factors of inflammatory response ( 34 , 35 ). Various inflammatory factors are produced during CPB, which may induce myocardial injury directly or indirectly ( 36 ).…”

Section: Discussionmentioning

confidence: 99%

Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats

et al. 2018

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Myocardial ischemia, hypoxia and reperfusion injury are induced by aortic occlusion, cardiac arrest and resuscitation during cardiopulmonary bypass (CPB), which can severely affect cardiac function. The aim of the present study was to investigate the effects of hydrogen-rich solution (HRS) and aquaporin (AQP) on cardiopulmonary bypass (CPB)-induced myocardial injury, and determine the mechanism of the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. Sprague Dawley rats were divided into a sham operation group, a CPB surgery group and a HRS group. A CPB model was established, and the hemodynamic parameters were determined at the termination of CPB. The myocardial tissues were observed by hematoxylin and eosin, and Masson staining. The levels of myocardial injury markers [adult cardiac troponin I (cTnI), lactate dehydrogenase (LDH), creatine kinase MB (CK-MB) and brain natriuretic peptide (BNP)], inflammatory factors [interleukin (IL)-1β, IL-6 and tumor necrosis factor-α (TNF-α)] and oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO)] were determined by ELISA. Furthermore, H9C2 cells were treated with HRS following hypoxia/reoxygenation. Cell viability and cell apoptosis were investigated. The expression of apoptosis regulator Bcl-2 (Bcl-2), apoptosis regulator Bax (Bax), caspase 3, AQP-1, AQP-4, phosphorylated (p)-Akt, heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) were investigated using western blotting and quantitative-polymerase chain reaction of tissues and cells. Following CPB, myocardial cell arrangement was disordered, myocardial injury markers (cTnI, LDH, CK-MB and BNP), inflammatory cytokines (IL-1β, IL-6 and TNF-α) and MDA levels were significantly increased compared with the sham group; whereas the SOD levels were significantly downregulated following CPB compared with the sham group. HRS attenuated myocardial injury, reduced the expression levels of cTnI, LDH, CK-MB, BNP, IL-1β, IL-6, TNF-α, MDA and MPO, and increased SOD release. Levels of Bcl-2, AQP-1, AQP-4, p-Akt, HO-1 and Nrf2 were significantly increased following HRS; whereas Bax and caspase-3 expression levels were significantly reduced following CPB. HRS treatment significantly increased the viability of myocardial cells, reduced the rate of myocardial cell apoptosis and the release of MDA and LDH compared with the CPB group. A PI3K inhibitor (LY294002) was revealed to reverse the protective effect of HRS treatment. HRS was demonstrated to attenuate CPB-induced myocardial injury, suppress AQP-1 and AQP-4 expression following CPB treatment and protect myocardial cells via the PI3K/Akt signaling pathway.

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Section: Discussionmentioning

confidence: 99%

Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats

et al. 2018

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“…[11] Aynı zamanda, sevofluranın bronkodilatasyonu, bozulmuş akciğer dokusu mekaniğini ve gelişmiş intrapulmoner şantları hafifletebilme etkilerinden de faydalanarak literatürde belirtildiği gibi akciğer fonksiyon bozukluğu olan bu hastada volatil ajan ile hem hemodinamik hem de respiratuvar avantaj sağlayabildik. [12] Sonuç olarak, eş zamanlı akciğer ve kardiyak cerrahi girişimlerde, başarı dikkatli cerrahi manipülasyonun yanında, anesteziyologların hemodinamik durumu korumak ve oksijen sunum-tüketim dengesini sağlayarak cerrahi güvenliği artırmasıyla birliktedir. Bu nedenle, yakın izlem ve monitörizasyon, anestezik ajanların hemodinami ve oksijenasyon ile birlikte titrasyonu ve hedefe yönelik sıvı tedavisinin önemini vurgulamak istedik.…”

Section: Discussionunclassified

Anesthetıc Approach In A Case Of Concurrent Off-Pump Coronary Bypass And Lung Resectıon

Kesimci¹

2022

GKDA Derg

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“…The CPB-induced systemic inflammatory response and lung IR injury were associated with pulmonary dysfunction [ 97 ], which can result in airway constriction, atelectasis, hypoxemia, elevated right heart afterload, and reduced systemic venous return [ 98 ].…”

Section: Clinical Translation Of Anaesthetic Cardioprotectionmentioning

confidence: 99%

Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery—A Narrative Review

Ştefan

Predoi

Goicea

et al. 2022

JCM

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Recent research has contested the previously accepted paradigm that volatile anaesthetics improve outcomes in cardiac surgery patients when compared to intravenous anaesthesia. In this review we summarise the mechanisms of myocardial ischaemia/reperfusion injury and cardioprotection in cardiac surgery. In addition, we make a comprehensive analysis of evidence comparing outcomes in patients undergoing cardiac surgery under volatile or intravenous anaesthesia, in terms of mortality and morbidity (cardiac, neurological, renal, pulmonary).

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Sevoflurane Relieves Lung Function Deterioration After Cardiopulmonary Bypass

Cited by 10 publications

References 34 publications

Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats

Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats

Anesthetıc Approach In A Case Of Concurrent Off-Pump Coronary Bypass And Lung Resectıon

Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery—A Narrative Review

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