Abstract:Objective Volatile anesthetics are widely used for general anesthesia during surgical operations. Voltagegated Na + channels expressed in central neurons are major targets for volatile anesthetics; but it is unclear whether these drugs modulate native tetrodotoxinresistant (TTX-R) Na + channels, which are involved in the development and maintenance of inflammatory pain.
MethodsIn this study, we examined the effects of sevoflurane on TTX-R Na + currents (I Na ) in acutely isolated rat dorsal root ganglion neuro… Show more
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