Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis

Deng, Xiaoqian; Vipani, Megha; Ge, Liang; Gouda, Divakara; Wang, Beibei; Wei, Huafeng

doi:10.1186/s12871-020-01139-y

Cited by 17 publications

(17 citation statements)

References 29 publications

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“…Significant differences were observed between groups, with propofol showing an inhibitory effect on signaling pathways involved in carcinogenesis [172]. Deng et al exposed breast cancer cell lines to sevofluorane vs. propofol, and observed an increase in tumor survival in the propofol group, mediated by the modulation of intracellular calcium homeostasis [173]. In contrast, Liu et al observed that sevoflurane suppressed breast cancer cell proliferation through an increase in miRNA-203 overexpression [174].…”

Section: Mirnas and Drugs Used During Anaesthetic Proceduresmentioning

confidence: 99%

Breast Cancer and Anaesthesia: Genetic Influence

Ponferrada

Orriach

Ruiz

et al. 2021

IJMS

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Breast cancer is the leading cause of mortality in women. It is a heterogeneous disease with a high degree of inter-subject variability even in patients with the same type of tumor, with individualized medicine having acquired significant relevance in this field. The clinical and morphological heterogeneity of the different types of breast tumors has led to a diversity of staging and classification systems. Thus, these tumors show wide variability in genetic expression and prognostic biomarkers. Surgical treatment is essential in the management of these patients. However, the perioperative period has been found to significantly influence survival and cancer recurrence. There is growing interest in the pro-tumoral effect of different anaesthetic and analgesic agents used intraoperatively and their relationship with metastatic progression. There is cumulative evidence of the influence of anaesthetic techniques on the physiopathological mechanisms of survival and growth of the residual neoplastic cells released during surgery. Prospective randomized clinical trials are needed to obtain quality evidence on the relationship between cancer and anaesthesia. This document summarizes the evidence currently available about the effects of the anaesthetic agents and techniques used in primary cancer surgery and long-term oncologic outcomes, and the biomolecular mechanisms involved in their interaction.

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Section: Mirnas and Drugs Used During Anaesthetic Proceduresmentioning

confidence: 99%

Breast Cancer and Anaesthesia: Genetic Influence

Ponferrada

Orriach

Ruiz

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…In a colorectal cancer cell line, desflurane (10.3%) induces EMT and metastasis through dysregulation of miR-34/LOXL3 axis a well-known tumor suppressor ( 64 ). Sevoflurane (2% for six hours), in vitro , increases survival of breast cancer cells via modulation of intracellular Ca 2+ homeostasis ( 65 ). Secondly, volatile anesthetics could facilitate cancer progression by inducing immunosuppression.…”

Section: Inhalational Agents and Intravenous Anesthetics For Cancer Surgerymentioning

confidence: 99%

“…Sevoflurane (2% for six hours), in vitro, increases survival of breast cancer cells via modulation of intracellular Ca 2+ homeostasis (65). Secondly, volatile anesthetics could facilitate cancer progression by inducing immunosuppression.…”

Section: Volatile Anestheticsmentioning

confidence: 99%

Anesthesia Techniques and Long-Term Oncological Outcomes

Ramirez

Cata

2021

Front. Oncol.

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Despite advances in cancer treatments, surgery remains one of the most important therapies for solid tumors. Unfortunately, surgery promotes angiogenesis, shedding of cancer cells into the circulation and suppresses anti-tumor immunity. Together this increases the risk of tumor metastasis, accelerated growth of pre-existing micro-metastasis and cancer recurrence. It was theorized that regional anesthesia could influence long-term outcomes after cancer surgery, however new clinical evidence demonstrates that the anesthesia technique has little influence in oncologic outcomes. Several randomized controlled trials are in progress and may provide a better understanding on how volatile and intravenous hypnotics impact cancer progression. The purpose of this review is to summarize the effect of the anesthesia techniques on the immune system and tumor microenvironment (TME) as well as to summarize the clinical evidence of anesthesia techniques on cancer outcomes.

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“…An interesting question remains whether the known effects of volatile anesthetics on immune function are detrimental for cancer recurrence and metastatic conversion. In vitro and in vivo studies have shown that when breast, ovarian and renal cell carcinoma cells are exposed to volatile gases there is increased cytokine release (IL-1/6/8 and TNF), NK and T-cell modulation as well as an increase in growth, angiogenic and migration factors ( 3 , 7 , 37 – 39 ). However, for other cancer types such as non-small cell lung cancer (NSCLC) exposure to volatile anesthetics has been shown to be suppressive of growth and migration ( 40 ).…”

Section: Tiva Vs Volatile Gas Anesthesiamentioning

confidence: 99%

Anesthesia and Cancer, Friend or Foe? A Narrative Review

Montejano

Jevtović-Todorović

2021

Front. Oncol.

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Cancer remains the leading cause of death worldwide with close to 10 million deaths reported annually. Due to growth of the advanced age cohort in our population, it is predicted that the number of new cancer cases diagnosed between now until 2035 is to reach potentially 24 million individuals, a staggering increase in a relatively short time period. For many solid tumors, surgical resection along with chemotherapy is the best available approach to a potential cure which leads to almost 80% of cancer patients undergoing at least one surgical procedure during the course of their disease. During surgical intervention, the exposure to general anesthesia can be lengthy, complex and often involves various modalities resulting in an important question as to the role, if any, anesthesia may play in primary recurrence or metastatic conversion. Many components of the stress and inflammatory responses exhibited in the perioperative period can contribute to cancer growth and invasion. The agents used to induce and maintain general anesthesia have variable interactions with the immune and neuroendocrine systems and can influence the stress response during surgery. Thus, debating the best type of anesthesia that would help to attenuate sympathetic and/or pro-inflammatory responses while modulating cytokine release and transcription factors/oncogenes remains at the forefront. This may affect inducible cancer cell survival and migratory abilities not only intra-operatively, but also during the immediate post-operative phase of recovery. The ultimate question becomes how and whether the choice of anesthesia may influence the outcomes of cancer surgery with two major approaches being considered, i.e., regional and general anesthesia as well as the various hypnotics, analgesics and sympatholytics commonly used. In this review, we will address the latest information as to the role that anesthesia may play during cancer surgery with specific focus on primary recurrence and metastasis.

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Sevoflurane modulates breast cancer cell survival via modulation of intracellular calcium homeostasis

Cited by 17 publications

References 29 publications

Breast Cancer and Anaesthesia: Genetic Influence

Breast Cancer and Anaesthesia: Genetic Influence

Anesthesia Techniques and Long-Term Oncological Outcomes

Anesthesia and Cancer, Friend or Foe? A Narrative Review

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