Sevoflurane induces less cerebral vasodilation than isoflurane at the same A‐line^® autoregressive index level

Abstract

Sevoflurane induced less cerebral vasodilation than isoflurane at the same depth of anesthesia, measured by AAI, and hence seems more favorable for clinical neuroanesthesia. In our opinion the difference between sevoflurane and isoflurane in the MAC fraction required to attain the same AAI level demonstrates the limitations of MAC in defining the level of anesthesia.

Changes of Cerebral Blood Flow during the Secondary Expansion of a Cortical Contusion Assessed by14C-Iodoantipyrine Autoradiography in Mice Using a Non-Invasive Protocol

“…The only other laboratory which measured CBF after TBI in mice used isoflurane anesthesia and froze the brains with some delay after sacrifice (Lundblad et al, 2004(Lundblad et al, , 2007. Since isoflurane is well known to increase CBF significantly (Holmstrom et al, 2005) and post-mortem diffusion of 14 C-iodoantipyrine from the intravascular space into the brain parenchyma is one of the most prominent sources for overestimating CBF when using 14 C-iodoantipyrine autoradiography (Lumblad, 2004), it is conceivable that by avoiding these two sources of possible artifact we may have obtained lower, though more physiological cortical blood flow measurements than previously reported. FIG.…”

Volatile sedation with sevoflurane in intensive care patients with acute stroke or subarachnoid haemorrhage using AnaConDa®: an observational study

“…As a result, the safety and feasibility of sevoflurane for sedation in the NCCU is unclear. [3][4][5][6][7][8][9][10] With a more widespread administration of sevoflurane to ICU patients with primary or secondary brain injury, potential benefits as well as harms might go unnoticed if multimodality neuromonitoring is not utilized. To clarify the potential benefits and safety concerns regarding sevoflurane sedation, we prospectively analysed the switch from i.v.…”

Dose-Dependent Influence of Sevoflurane Anesthesia on Neuronal Survival and Cognitive Outcome After Transient Forebrain Ischemia in Sprague-Dawley Rats

“…Sevoflurane is considered to be the most suitable volatile anesthetic for neuroanesthesia [7], because of its minimal cerebral vasodilatory effects and, as a consequence, almost not present influence on intracranial pressure [8][9][10]. Furthermore, low blood-gas solubility enables rapid recovery from anesthesia, which is essential for immediate detection of postoperative surgical complications, such as secondary intracranial hemorrhage or cerebral edema.…”