Sevoflurane in patients at risk of ventricular dysrhythmias

Charbit, Beny

doi:10.1007/s00540-017-2346-y

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2023

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Cited by 2 publications

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“…I wish to thank Dr. Charbit for his comments [1] on our recent article [2]. I address his comments here.…”

Section: To the Editormentioning

confidence: 96%

In reply: Sevoflurane in patients at risk of ventricular dysrhythmias

Terao

2017

J Anesth

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“…I wish to thank Dr. Charbit for his comments [1] on our recent article [2]. I address his comments here.…”

Section: To the Editormentioning

confidence: 96%

In reply: Sevoflurane in patients at risk of ventricular dysrhythmias

Terao

2017

J Anesth

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“…In previous studies, majority of experts consider that sevo urane prolonged the QTc interval signi cantly and increased the risk of ventricular arrhythmia. [5][6][7] It also has been reported that sevo urane prolong the QT interval without affecting the Tp-e interval or QT interval. [8][9][10] Therefore, nding an e cient biomarker that can correctly evaluate the effects of sevo urane or other drugs on cardiac electrophysiology has a great importance in clinical.…”

Section: Introductionmentioning

confidence: 99%

Index of cardiac electrophysiological balance can better predict the risk of arrhythmia than QT and Tp-e interval in patients inhalating sevoflurane

2023

Preprint

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Objective: To compare the value of ECG markers such as QT interval, Tp-e interval and index of cardiac electrophysiological balance (iCEB) in evaluating the effect of sevoflurane on cardiac electrophysiology. Methods: Sixty patients undergoing elective gynecological surgery were randomly divided into group S1, group S2 and group S3, 20 cases in each group. Patients were received 10ml/kg of hydroxyethyl starch, 0.1mg/kg of midazolam, 0.1 mg/kg of vecuronium, 3μg/kg of fentanyl and 0.3mg/kg of etomidate intravenously. Mechanical ventilation was performed after endotracheal intubation. Sevoflurane concentration was maintained at 0.6 MAC, 1.3 MAC and 2.0 MAC in group S1, group S2 and group S3 respectively. The QT interval, QRS interval and Tp-e interval were measured before anesthesia induction (T1), 5 minutes after tracheal intubation (T2), and 20 minutes after rising to the set concentration of sevoflurane (T3). The QTc interval, Tp-e/QT ratio and iCEB were measured and calculated. MAP and HR were recorded at the same time. Results Compared with T1-2, MAP and HR decreased at T3 in S1-3 group (P < 0.05); Compared with T1, iCEB increased at T2-3 in S1-3 groups, QTc interval prolonged at T3 in S1-3 groups (P < 0.05). Compared with T2, iCEB increased at T3 in S1-3 groups. Compared with S1 group , the Tp-e Shortened, iCEB increased in S2-3 groups . Compared with S2 group, iCEB decreased in S3 group at T3. Conclusion: iCEB is more sensitive and objective, and can better predict the risk of arrhythmia. iCEB can be used as the preferred index to evaluate the electrophysiological effects by anesthetics in clinic.

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Sevoflurane in patients at risk of ventricular dysrhythmias

Abstract: Terao et al. In these patients, propofol should be preferred, without sevoflurane, for both induction and maintenance of anesthesia [5], especially as the present work confirms the good electrophysiological tolerance of propofol.

Cited by 2 publications

References 5 publications

In reply: Sevoflurane in patients at risk of ventricular dysrhythmias

In reply: Sevoflurane in patients at risk of ventricular dysrhythmias

Index of cardiac electrophysiological balance can better predict the risk of arrhythmia than QT and Tp-e interval in patients inhalating sevoflurane

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