Sevoflurane Exerts an Anti-depressive Action by Blocking the HMGB1/TLR4 Pathway in Unpredictable Chronic Mild Stress Rats

Guo, Zhenggang; Zhao, Feng; Wang, Ye; Geng, Miaomiao; Zhang, Yilei; Qing-xia, MA; Xu, Xiuzheng

doi:10.1007/s12031-019-01380-2

Cited by 17 publications

(9 citation statements)

References 37 publications

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“…TLR4, a pattern recognition receptor, is expressed in a range of cells, such as microglia, astrocytes and neurons, and plays an important role in regulating the inflammatory response to stress (Guo et al, 2019). HMGB1 and TLR4 form a ligand–receptor pair that is involved in diseases characterized by cell death and injury (Guo et al, 2019), including depression (Guo et al, 2019; Xu et al, 2020) and liver injury (Lu et al, 2020). In addition, TNF‐α, as a key inflammatory factor, can disrupt the integrity of the blood–brain barrier (Cheng et al, 2018) and induce depression‐like behaviour in mice (Qian, Wang, Tao, Long, & Wang, 2017).…”

Section: Introductionmentioning

confidence: 99%

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Piao

Aosai

et al. 2020

British J Pharmacology

150

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Background and Purpose: Arctigenin, a major bioactive component of Fructus arctii, has been reported to have antidepressant-like effects. However, the mechanisms underlying these effects are still unclear. Neuroinflammation can be caused by excessive production of proinflammatory cytokines in microglia via high-mobility group box 1 (HMGB1)/TLR4/NF-κB and TNF-α/TNFR1/NF-κB signalling pathways, leading to depression. In this study, we have investigated the antidepressant mechanism of arctigenin by conducting in vitro and in vivo studies. Experimental Approach: The effects of chronic unpredictable mild stress (CUMS) on wild-type (WT) and TLR4 −/− mice were examined. Antidepressant-like effects of arctigenin were tested using the CUMS-induced model of depression in WT mice. The effects of arctigenin were assessed on the HMGB1/TLR4/NF-κB and TNF-α/TNFR1/NF-κB signalling pathways in the prefrontal cortex (PFC) of mouse brain and HMGB1-or TNF-α-stimulated primary cultured microglia. The interaction between HMGB1 and TLR4 or TNF-α and TNFR1 with or without arctigenin was examined by localized surface plasmon resonance (LSPR) and coimmunoprecipitation assays.

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Section: Introductionmentioning

confidence: 99%

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Piao

Aosai

et al. 2020

British J Pharmacology

150

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“…The degree of damage is primarily dependent on the concentration of the anesthetic and the duration of exposure (23). According to previous hypotheses, in the present study, a concentration of 2% sevoflurane was administered to rats during early pregnancy (15)(16)(17)(18). Repeated sevoflurane exposure has also been reported to suppress the proliferation of neural progenitors in offspring (24).…”

Section: Discussionmentioning

confidence: 66%

“…Sevoflurane exposure. Rats in the control group were untreated, and those in the two sevoflurane exposure groups (S1 and S2) were exposed to 2% sevoflurane (15)(16)(17)(18). All rats were placed in separate cages and treated using 100% oxygen as a carrier gas, with a 4 l/min total gas flow.…”

Section: Animalsmentioning

confidence: 99%

Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats

Zhu

Liu

et al. 2021

Exp Ther Med

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The aim of the present study was to investigate the effect of exposure to sevoflurane general anesthesia during early pregnancy on interferon-inducible protein AIM2 (AIM2) expression in the hippocampus and parietal cortex of the offspring Sprague-Dawley (SD) rats. A total of 18 SD rats at a gestational age of 5-7 days were randomly divided into three groups: i) A control group (control); ii) 2-h sevoflurane general anesthesia, group 1 (S1); and iii) 4-h sevoflurane general anesthesia, group 2 (S2). The six offspring rats in each group were maintained for 30 days and assessed by Morris water maze testing. Brain specimens were collected from offspring rats 30 days after birth. Changes in the structural morphology of neurons in the hippocampus and parietal cortex were observed using hematoxylin and eosin staining. Nissl bodies in the hippocampus and parietal cortex were observed by Nissl staining. The expression of glial fibrillary acidic protein (GFAP), AIM2, CD45 and IL-1β was detected by immunohistochemistry and the protein levels of CD45, IL-1β, pro-caspase-1 and caspase-1 p10 were detected by western blotting. Compared with the control group, offspring rats in the S1 and S2 groups exhibited poor long-term learning and memory ability and experienced different degrees of damage to both the hippocampus and parietal cortex. The expression levels of GFAP, AIM2, CD45, IL-1β, caspase-1 and caspase-1 p10 in the offspring of both the S1 and the S2 groups were significantly increased (P<0.05) compared with offspring of the control group. Moreover, compared with the offspring of the S1 group, hippocampal and parietal cortex injury in the offspring of the S2 group was further aggravated, and the expression of GFAP, AIM2, CD45, IL-1β, pro-caspase-1 and cleaved-caspase-1 was significantly increased (P<0.05). In conclusion, sevoflurane general anesthesia in SD rat early pregnancy promoted the expression of AIM2 and the inflammatory response in the hippocampus and parietal cortex of offspring rats.

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“…We postulate that the combination of (R,S)-ketamine and dexmedetomidine may enhance the antidepressant effect. Sevoflurane can exert antidepressant effects by blocking the HMGB1/TLR4 signal transduction pathway (Guo et al, 2019). Therefore, the combined use of sevoflurane and (R,S)-ketamine during surgery may enhance the antidepressant effect.…”

Section: Discussionmentioning

confidence: 99%

Can Intraoperative Low-Dose R,S-Ketamine Prevent Depressive Symptoms After Surgery? The First Meta-Analysis of Clinical Trials

et al. 2020

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Background: Postoperative depression is a common complication after surgery that profoundly affects recovery and prognosis. New research indicates that (R,S)-ketamine is a potent antidepressant that exerts a rapid and sustained antidepressive effect. However, there is no consensus on whether intraoperative low-dose (R,S)-ketamine prevents postoperative depression. Objectives: This study aimed to investigate the safety, feasibility, and short-term complications of intraoperative low-dose (R,S)-ketamine in preventing postoperative depressive symptoms. Methods: The Web of Science, Cochrane, PubMed, and CNKI databases were systematically searched (last search February 28, 2020) to identify studies involving ketamine. Sensitivity and metaregression analyses were performed to identify potential confounders. The meta-analysis was performed using Review Manager 5.3. Results: A total of 13 studies (seven in Chinese and six in English) representing 1,148 cases of patients who were treated with (R,S)-ketamine and 874 cases of patients who received other treatments were included in the meta-analysis. Anesthesia duration and blood loss did not significantly differ between the two groups, demonstrating that (R,S

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Sevoflurane Exerts an Anti-depressive Action by Blocking the HMGB1/TLR4 Pathway in Unpredictable Chronic Mild Stress Rats

Cited by 17 publications

References 37 publications

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1/TLR4/NF‐κB and TNF‐α/TNFR1/NF‐κB pathways

Effects of sevoflurane general anesthesia during early pregnancy on AIM2 expression in the hippocampus and parietal cortex of Sprague‑Dawley offspring rats

Can Intraoperative Low-Dose R,S-Ketamine Prevent Depressive Symptoms After Surgery? The First Meta-Analysis of Clinical Trials

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