“…3,9 There has been extensive research on the effects of anesthetic agents, both volatile and intravenous, on mediators and pathways involved in smooth muscle cell vasoconstriction/vasodilation. 70,74 Some of the pathways studied include receptor activation, Ca2+ mobilization, myofilament Ca 2+ sensitivity, and potassium-chloride/ Rho kinase, as well as modulation of vascular tone in response to medications and other stimuli. 70,74 The endothelium contributes to aortic biomechanics through its effects on viscoelasticity and direct vasodilation via smooth muscle cells.…”