Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study

Bahmer, Thomas; Borzikowsky, Christoph; Lieb, Wolfgang; Horn, Anna; Krist, Lilian; Fricke, Julia; Scheibenbogen, Carmen; Rabe, Klaus F.; Maetzler, Walter; Maetzler, Corina; Laudien, Martin; Frank, Derk; Ballhausen, Sabrina; Hermes, Anne; Muljukov, Olga; Hæusler, Karl Georg; Mokhtari, Nour Eddine El; Witzenrath, Martin; Vehreschild, Jörg Janne; Krefting, Dagmar; Pape, Daniel; Montellano, Felipe A.; Kohls, Mirjam; Morbach, Caroline; Störk, Stefan; Reese, Jens‐Peter; Keil, Thomas; Heuschmann, Peter U.; Krawczak, Michael; Schreiber, Stefan

doi:10.1016/j.eclinm.2022.101549

Cited by 80 publications

(76 citation statements)

References 25 publications

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“…COVIDOM is a population-based, prospective multicentre study in the German National Pandemic Cohort Network (NAPKON). 15 , 16 Patient inclusion criteria were: (i) a positive polymerase chain reaction (PCR) test for SARS-CoV-2, (ii) a primary residence in in the administrative regions of Schleswig-Holstein or Würzburg, and (iii) age ≥18 years at the time of infection. Patients were invited by mail through public health authorities.…”

Section: Methodsmentioning

confidence: 99%

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Hartung¹,

Neumann²,

Bahmer³

et al. 2022

eClinicalMedicine

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Section: Methodsmentioning

confidence: 99%

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Hartung¹,

Neumann²,

Bahmer³

et al. 2022

eClinicalMedicine

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“…Most studies indicate female sex and older age as risk factors for long-term neurological consequences of the COVID-19 [ 39 , 42 , 47 , 48 , 49 , 50 ].…”

Section: Predictors Of Post-covid Neurological Complicationsmentioning

confidence: 99%

“…Data on the relationship of the disease severity with the likelihood of long-term consequences of COVID-19 are contradictory. A number of studies showed the association of the severity of the acute COVID-19 with the occurrence of long-term neurological consequences [ 23 , 39 , 42 , 46 , 48 , 49 , 50 ]. It was also found that the number of initial symptoms better predicts the presence of long COVID than the severity of the acute phase of the disease [ 47 , 50 , 56 ].…”

Section: Predictors Of Post-covid Neurological Complicationsmentioning

confidence: 99%

“…Both demyelinating diseases and long COVID are characterized by fatigue, delirium, depression, cognitive and sensory impairment [ 7 , 67 , 127 ]. For both diseases, female sex is a risk factor [ 39 , 42 , 47 , 48 , 49 , 50 , 128 ]. However, it should be noted that there is some discrepancy between the predictors of MS and the cytokine storm, which can be considered as a mechanism of post-COVID demyelination.…”

Section: Possible Mechanisms Of Demyelination Caused By Covid-19mentioning

confidence: 99%

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Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19

Khodanovich

Parshukova

Naumova

2022

IJMS

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Long-term neurological and mental complications of COVID-19, the so-called post-COVID syndrome or long COVID, affect the quality of life. The most persistent manifestations of long COVID include fatigue, anosmia/hyposmia, insomnia, depression/anxiety, and memory/attention deficits. The physiological basis of neurological and psychiatric disorders is still poorly understood. This review summarizes the current knowledge of neurological sequelae in post-COVID patients and discusses brain demyelination as a possible mechanism of these complications with a focus on neuroimaging findings. Numerous reviews, experimental and theoretical studies consider brain demyelination as one of the mechanisms of the central neural system impairment. Several factors might cause demyelination, such as inflammation, direct effect of the virus on oligodendrocytes, and cerebrovascular disorders, inducing myelin damage. There is a contradiction between the solid fundamental basis underlying demyelination as the mechanism of the neurological injuries and relatively little published clinical evidence related to demyelination in COVID-19 patients. The reason for this probably lies in the fact that most clinical studies used conventional MRI techniques, which can detect only large, clearly visible demyelinating lesions. A very limited number of studies use specific methods for myelin quantification detected changes in the white matter tracts 3 and 10 months after the acute phase of COVID-19. Future research applying quantitative MRI assessment of myelin in combination with neurological and psychological studies will help in understanding the mechanisms of post-COVID complications associated with demyelination.

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“…Ein weiterer wichtiger Aspekt ist die Komplexität der Abbildung einer solch weiten Definition in großen Kohortenstudien, wie beispielsweise im Nationalen Pandemie-Kohorten-Netzwerk (NAP-KON), einem Projekt im Rahmen des NUMs [39,40] Merke Für aktuelle und zukünftige Forschungsfragen sollten die Kriterien, die Patient*innen mit langfristigen Symptomen charakterisieren, objektiviert werden, indem standardisierte Fragebögen, die alle Aspekte des biopsychosozialen Modells abbilden, genutzt werden und auch funktionelle Einschränkungen mit erfassen. Neben Aktivitätstest wie dem häufig genutzten 6-Minuten-Gehtest, ist auch die Post-COVID-Functional-Scale eine praxisorientierte Möglichkeit [16,36].…”

Section: Standardisierung Des Assessments Erforderlichunclassified

Post-COVID: Alles eine Frage der Definition?

Lemhöfer

Appel

Haüser

et al. 2022

Dtsch Med Wochenschr

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ZusammenfassungDie Prävalenz des Post-COVID-Syndroms (PCS) ist noch nicht abschließend geklärt. Die bisherigen Definitionen bilden vorrangig zeitliche Aspekte ab, lassen jedoch funktionelle Defizite sowie die Objektivierung von Symptomen außer Acht. Dies führt zu diagnostischen sowie therapeutischen Unklarheiten. In Pubmed wurde daher nach systematischen Reviews gesucht, die sich mit den Folgen einer SARS-CoV-2-Infektion befassten. Die zugrunde liegenden Definitionen sowie zeitlichen Einschlusskriterien wurden extrahiert. 16 systematische Reviews wurden eingeschlossen, davon 11 mit einer Definition des PCS. In 58 % der analysierten Einzelstudien wurden Patienten mit einer Symptomatik > 12 Wochen und damit entsprechend der Definition des PCS inkludiert. Fazit: Eine weitere Präzisierung der Definition des PCS ist notwendig, um Diagnostik und eine multimodale Behandlung zu erleichtern und die knappen therapeutischen Ressourcen entsprechend zu nutzen.

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Severity, predictors and clinical correlates of Post-COVID syndrome (PCS) in Germany: A prospective, multi-centre, population-based cohort study

Cited by 80 publications

References 25 publications

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Fatigue and cognitive impairment after COVID-19: A prospective multicentre study

Role of Demyelination in the Persistence of Neurological and Mental Impairments after COVID-19

Post-COVID: Alles eine Frage der Definition?

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