Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014

Severi, Ettore; Georgalis, Leonidas; Pijnacker, Roan; Veneti, Lamprini; Turiac, Iulia Adelina; Chiesa, Flaminia; Rizzo, Caterina; Martinelli, Domenico; Vold, Line; Herrador, Bernardo Guzman; Martínez, Carmen Varela; Sánchez, Elena Vanessa Martínez; Semenza, Jan C.; Lopalco, Pierluigi; Dahlström, Lisen Arnheim; Giesecke, Johan

doi:10.1016/j.ijid.2022.01.053

Cited by 8 publications

(11 citation statements)

References 29 publications

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“…Due to the low endemicity of the Hepatic Virus A in Italy, infections are usually found in susceptible adults who may manifest severe symptoms [ 35 ]. The rate of hospitalization in this country has been extensively described by Severi et al [ 36 ] for the years 2001–2013; the authors were surprised by the records of hospitalizations that exceeded those of the notifications, and they explained this paradox considering the well-known underestimation of HAV human cases in Italy, as reported previously [ 30 ]. According to PREMAL data relating to hospitalization rates during the period 2013–2019, in Campania about 95% of all individuals registered in the surveillance system needed hospitalization.…”

Section: Discussionmentioning

confidence: 74%

Surveillance of Human Cases of Salmonellosis, Campylobacteriosis, Listeriosis, and Hepatitis A in Campania (Southern Italy): Seven-Year Monitoring (2013–2019)

Colarusso¹,

Peruzy

Mazzone³

et al. 2022

Pathogens

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Foodborne infections cause illness and death every year worldwide. The aim of this study was to describe trends in 2013–2019 in the occurrence of human cases of salmonellosis, campylobacteriosis, listeriosis, and hepatitis A in the Campania region. Human case data were provided by the National Surveillance System of disease and were grouped by year, province, age group, and sex. Moreover, the number of people hospitalized was recorded. In the Campania region, the total number of confirmed human cases for the diseases investigated was 1924, with Hepatitis A and the Salmonellosis as the first most reported (1009 and 825 cases, respectively). The incidence rates of gastroenteritis under study were lower than those in Italy and European Union in the same period, with the exception of Hepatitis A whose incidence was higher than that recorded in Italy. Data on hospitalizations pointed out the onset of severe forms of infection also for listeriosis and campylobacteriosis, whose incidence was very low (27 and 63 cases, respectively). Unfortunately, no information on the foods implicated is available. Although probably underestimated, gastroenteritis due to foodborne agents still represents a burden in Campania, and continuous monitoring and implementation of the currently available regional surveillance system is required.

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Section: Discussionmentioning

confidence: 74%

Surveillance of Human Cases of Salmonellosis, Campylobacteriosis, Listeriosis, and Hepatitis A in Campania (Southern Italy): Seven-Year Monitoring (2013–2019)

Colarusso¹,

Peruzy

Mazzone³

et al. 2022

Pathogens

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“…Although fulminant forms of HAV may occur in the elderly due to significant alcohol consumption and chronic HBV infection (10). As a result of studies associated with the severity of clinical manifestations of hepatitis A in five European countries, no increase in the severity of the clinical picture in patients with hepatitis A was revealed, and elderly patients with liver diseases are at increased risk of severe disease and should be a priority for vaccination (11,12).…”

Section: Herpes Virus Hominismentioning

confidence: 99%

Etiology, clinical and laboratory characteristics, and outcomes in patients with acute viral hepatitis

Ainura¹,

Lira²,

Aisuluu³

et al. 2022

Biomedicine

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Introduction and Aim: Kyrgyzstan is one of the most focused countries in the WHO European Region for acute viral hepatitis. The objective of this study is to evaluate the etiology, clinical and laboratory characteristics, and outcomes in patients with acute viral hepatitis. Materials and Methods: This is a prospective study conducted on 122 patients with acute viral hepatitis at our hospital from March 2017 to June 2020. The diagnosis of acute viral hepatitis was based on the standard case definition: sudden onset with symptoms of a) acute illness (fever, malaise, weakness); b) liver damage (anorexia, nausea, jaundice, dark urine, right upper quadrant tenderness); c) elevation activity of alanine aminotransferase is more than ten times compared to normal levels. Results: One hundred and twenty-two patients with acute viral hepatitis, including hepatitis A virus - 44 (36.1%), hepatitis B virus - 45 (36.9%), hepatitis C virus - 11 (9.0%), unspecified etiology - 22 (18, 0%). Patients with unidentified hepatitis, diagnosed through anti-HSV IgG was detected in 19 (86.4%) cases, anti-EBV IgG was detected in 18 (81.8%) cases, and 14 (63.6%) patients with anti-CMV IgG were present. Conclusion: This study demonstrates the need to consider herpes viruses in the differential diagnosis of patients with unspecified liver lesions.

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“…And it is a frequent cause of foodborne infections worldwide, resulting in sporadic cases, outbreaks or epidemics 2. HepA is highly endemic in most developing countries and usually occurs in early childhood 3. Severe cases can result in jaundice, acute hepatitis and even death.…”

Section: Introductionmentioning

confidence: 99%

“… 2 HepA is highly endemic in most developing countries and usually occurs in early childhood. 3 Severe cases can result in jaundice, acute hepatitis and even death. Currently, there are no highly effective antiviral drugs available on the market for treating HepA.…”

Section: Introductionmentioning

confidence: 99%

Assessing the effectiveness of the expanded hepatitis A vaccination program in China: an interrupted time series design

Wu,

Wang,

Huang

et al. 2024

BMJ Glob Health

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IntroductionChina initialised the expanded hepatitis A vaccination programme (EHAP) in 2008. However, the effectiveness of the programme remains unclear. We aimed to comprehensively evaluate the effectiveness of EHAP in the country.MethodsBased on the provincial data on the incidence of hepatitis A (HepA), the population and meteorological variables in China, we developed interrupted time series (ITS) models to estimate the effectiveness of EHAP with the autocorrelation, seasonality and the meteorological confounders being controlled. Results were also stratified by economic zones, age groups and provinces.ResultsWe found a 0.9% reduction (RR=0.991, 95% CI: 0.990 to 0.991) in monthly HepA incidence after EHAP, which was 0.3% greater than the reduction rate before EHAP in China. Across the three economic regions, we found a 1.1% reduction in HepA incidence in both central and western regions after EHAP, which were 0.3% and 1.2% greater than the reduction rates before EHAP, respectively. We found a decreased reduction rate for the eastern region. In addition, we found generally increased reduction rate after EHAP for age groups of 0–4, 5–14 and 15–24 years. However, we found decreased reduction rate among the 25–64 and ≥65 years groups. We found a slight increased rate after EHAP in Shanxi Province but not elsewhere.ConclusionOur finding provides comprehensive evidence on the effectiveness of EHAP in China, particularly in the central and western regions, and among the population aged 0–24 years old. This study has important implications for the adjustment of vaccination strategies for other regions and populations.

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Severity of the clinical presentation of hepatitis A in five European countries from 1995 to 2014

Cited by 8 publications

References 29 publications

Surveillance of Human Cases of Salmonellosis, Campylobacteriosis, Listeriosis, and Hepatitis A in Campania (Southern Italy): Seven-Year Monitoring (2013–2019)

Surveillance of Human Cases of Salmonellosis, Campylobacteriosis, Listeriosis, and Hepatitis A in Campania (Southern Italy): Seven-Year Monitoring (2013–2019)

Etiology, clinical and laboratory characteristics, and outcomes in patients with acute viral hepatitis

Assessing the effectiveness of the expanded hepatitis A vaccination program in China: an interrupted time series design

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