Severity of Scleritis and Episcleritis

Maza, Maite Sainz de la; Jabbur, Nada S.; Foster, C. Stephen

doi:10.1016/s0161-6420(94)31325-x

Cited by 192 publications

(129 citation statements)

References 11 publications

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“…In a retrospective study of 172 patients, anterior uveitis was found in 42% of patients with scleritis, cataracts were detected in 17%, PUK in 14%, glaucoma in 13%, and posterior segment disease in 6% [17]. In that same study, 37% of patients experienced a decrease in vision due to scleritis, defined as a loss of two or more lines of vision during follow up or a visual acuity of 20/80 or worse at presentation.…”

Section: Complications Of Scleritismentioning

confidence: 90%

“…Episcleritis is less likely to be associated with a systemic autoimmune condition than scleritis [17]. Ocular complications are also less likely in episcleritis, with vision loss occurring in none of the 37 patients in one study and only two of 94 (not related directly to episcleritis) in another [3,17]. Treatment is not necessary unless the redness is bothersome to the patient.…”

Section: Differential Diagnosis Of Scleritismentioning

confidence: 97%

“…Autoimmune conditions are found in approximately 40% of patients and infections in approximately 7% [3,18]. The most commonly associated rheumatic diseases are RA (18-33%); systemic vasculitis (7-19%), of which Wegener's granulomatosis is the most common; systemic lupus erythematosus (SLE)(4-7%); inflammatory bowel disease (4-7%), and relapsing polychondritis (3%) [3,17]. Less commonly associated conditions include sarcoidosis [19,20], cryoglobulinemia [21], and hypocomplementemic urticarial vasculitis [22].…”

Section: Systemic Conditions Associated With Scleritismentioning

confidence: 99%

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Scleritis and Peripheral Ulcerative Keratitis

Galor

Thorne

2007

Rheumatic Disease Clinics of North America

144

138

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Scleritis and peripheral ulcerative keratitis (PUK) can present as isolated conditions or as part of a systemic inflammatory or infectious disorder. Both are serious ocular conditions that can result in vision loss and therefore require early diagnosis and treatment. Nearly two-thirds of patients with non-infectious scleritis require systemic glucocorticoid therapy, and one fourth need a glucocorticoid-sparing agent, as well. Essentially all patients with non-infectious PUK require systemic glucocorticoids. Detailed clinical history, thorough physical examination, and thoughtful laboratory evaluations are all important in the exclusion of underlying disorders and extraocular involvement. KeywordsScleritis; peripheral ulcerative keratitis; glucocorticoids; cyclophosphamide; vasculitis; rheumatoid arthritis Scleritis and peripheral ulcerative keratitis (PUK) are two ocular disorders that require urgent attention for the purpose of diagnosis, treatment, and detection of underlying systemic inflammatory diseases.

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Section: Complications Of Scleritismentioning

confidence: 90%

Section: Differential Diagnosis Of Scleritismentioning

confidence: 97%

Section: Systemic Conditions Associated With Scleritismentioning

confidence: 99%

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Scleritis and Peripheral Ulcerative Keratitis

Galor

Thorne

2007

Rheumatic Disease Clinics of North America

144

138

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“…17,18 Various tissues have been used for patch grafting, including processed pericardium 19,20 sclera, 21,22 and fascia lata. 23 In our small series, treatment was initiated as early as possible with immunosuppressive treatment with high-dose corticosteroids and cytotoxic drugs as necessary, together with surgical replacement of damaged tissue.…”

Section: Discussionmentioning

confidence: 99%

Use of autologous fascia lata as a natural biomaterial for tectonic support in surgically induced necrotizing scleritis

Kobtan

2015

Eye

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Background Surgically induced scleral necrosis (SINS) is a severe form of scleritis threatening both vision and integrity of the eye. SINS is a rare sequel of ocular surgery and has been described after cataract extraction, trabeculectomy, strabismus, retinal detachment surgery including parsplana vitrectomy, penetrating keratoplasty, pterygium excision, and diode cyclophotocoagulation. Materials and methods To report on the application of autologous fascia lata as a readily available natural biomaterial for ocular tectonic support in SINS, we performed this retrospective chart review including two eyes of two patients; one case following both repaired rupture globe, parsplana vitrectomy, and diode laser transscleral cyclophotocoagulation and one case following pterygium surgical excision. Results Successful coverage of the area of scleral thinning with autologous fascia lata was achieved in both cases with overlying healthy vascularized conjunctiva and resolution of the ocular inflammation. Conclusion The fascia lata transplant combined with systemic immunosuppression was successful in providing adequate tectonic support and controlling the progression of scleral melt for two cases with SINS.

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“…Dentre as doenças mais frequentemente associadas à inflamação escleral podemos citar doenças infecciosas: herpes zoster oftálmico, herpes simples, sífilis, tuberculose (TBC); doenças reumáticas como artrite reumatóide e lúpus eritematoso sistêmico (LES); vasculites sistêmicas como granulomatose de Wegener, poliarterite nodosa, arterite de células gigantes e doença inflamatória intestinal como retocolite-ulcerativa e doença de Crohn (2)(3)(4) . Seu diagnóstico é difícil e sempre deve ser levado em consideração no diagnóstico diferencial de condições tais como: glaucoma de ângulo fechado, dobras de coróide, edema de disco óptico, descolamento seroso de retina, descolamento de coróide, exsudação sub-retiniana, tumor intraocular e efusão uveal (4)(5) . A avaliação diagnóstica é importante em todos os casos de esclerite e inclui avaliação clínica geral, com interrogatório dos sistemas e investigação laboratorial.…”

Section: Resumo Introduçãounclassified