Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months

Steinbeis, Fridolin; Thibeault, Charlotte; Doellinger, Felix; Ring, Raphaela Maria; Mittermaier, Mirja; Ruwwe-Gloesenkamp, Christoph; Alius, Florian; Knape, Philipp; Meyer, Hans-Jakob; Lippert, Lena J; Helbig, Elisa T; Grund, D.; Temmesfeld-Wollbrueck, Bettina; Suttorp, Norbert; Sander, Leif Erik; Kurth, Florian; Penzkofer, Tobias; Witzenrath, Martin; Zöller, Thomas

doi:10.1016/j.rmed.2021.106709

Cited by 67 publications

(95 citation statements)

References 48 publications

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“…A positive correlation of pulmonary restriction in follow-up with COVID-19 severity was described earlier, especially in hospitalised patients 20 , 21 . Data on mild or even asymptomatic courses are scarce.…”

Section: Discussionsupporting

confidence: 71%

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Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients

Kersten

Wolf

Hoyo

et al. 2022

Sci Rep

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After acute infection with the SARS-CoV-2 virus, a considerable number of patients remains symptomatic with pathological changes in various organ systems. This study aimed to relate the physical and mental burden of symptoms of long COVID patients to the findings of a somatic evaluation. In patients with persistent long COVID symptoms three months after acute infection we assessed physical and mental health status using the SF-36 questionnaire. The cohort was dichotomised by the results (upper two quartiles vs. lower to quartiles) and compared with regard to transthoracic echocardiography, body plethysmography (including diffusion capacity), capillary blood gas analysis and 6-min walk test (6-MWT). From February 22 to September 13, 2021, 463 patients were prospectively examined, of which 367 completed the SF-36 questionnaire. A positive correlation between initial disease severity (need for hospitalization, intensive care medicine) and resulting symptom burden at follow-up could be demonstrated. Patients with impaired subjective physical and mental status were significantly more likely to be women. There was a significant correlation between symptom severity and reduced exercise tolerance in the 6-MWT (495.6 ± 83.7 m vs 549.7 ± 71.6 m, p < 0.001) and diffusion capacity for carbon monoxide (85.6 ± 14.3% of target vs 94.5 ± 14.4, p < 0.001). In long COVID patients, initial disease severity is correlated with symptom burden after at least 3 months of follow-up. Highly symptomatic long COVID patients show impaired diffusion capacity and 6-MWT despite average or mildly affected mechanical lung parameters. It must be further differentiated whether this corresponds to a transient functional impairment or whether it is a matter of defined organ damage.

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Section: Discussionsupporting

confidence: 71%

“…In the longitudinal trial by Steinbeis et al, an improvement in respiratory function has been shown, including DLCO over time 20 . Considering the possible time course of DLCO and the significantly different observation times of the cohorts after COVID-19 infection in our collective, a possible confounder or coincidence is possible here.…”

Section: Discussionmentioning

confidence: 96%

Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients

Kersten

Wolf

Hoyo

et al. 2022

Sci Rep

View full text Add to dashboard Cite

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“…A total of 4112 patients were included, including 2127 males and 1985 females, of whom 2414 (58.7%) patients completed the carbon monoxide diffusing test. The mean/median age of the subjects of the 11 studies 25 , 26 , 28 , 29 , 30 , 31 , 32 , 34 , 35 , 37 , 38 on DLCO was over 50 years.…”

Section: Resultsmentioning

confidence: 98%

“…All of the 18 included studies are observational studies, of which 16 are cohort studies, 17 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 one is a prospective, cross-sectional study 40 and one is a cross-sectional case-control study. 41 The included studies were published between 2020 and 2021 and were conducted in seven countries including China, Germany, Italy, Spain, Chile, Norway and Saudi Arabia.…”

Section: Resultsmentioning

confidence: 99%

Risk factors for impaired pulmonary diffusion function in convalescent COVID-19 patients: A systematic review and meta-analysis

Zhi

Zhao

et al. 2022

eClinicalMedicine

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“…Those impairments correlated with a 66% reduction in 6-minute walk distance as well. Steinbeis et al ( 12 ) reported longitudinal measures of respiratory symptoms and lung function over 1 year in a cohort of COVID-19 survivors spanning from mild acute illness to ICU survivors. Among all patients, 43% reported dyspnea at 12 months, although data specific to ICU survivors alone were not presented.…”

Section: Discussionmentioning

confidence: 99%

Six-Month Impairment in Cognition, Mental Health, and Physical Function Following COVID-19–Associated Respiratory Failure

Maley

Sandsmark

Trainor

et al. 2022

Critical Care Explorations

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OBJECTIVES: To determine the prevalence and extent of impairments impacting health-related quality of life among survivors of COVID-19 who required mechanical ventilation, 6 months after hospital discharge. DESIGN: Multicenter, prospective cohort study, enrolling adults 18 years old or older with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 infection who received mechanical ventilation for 48 hours or more and survived to hospital discharge. Eligible patients were contacted 6 months after discharge for telephone-based interviews from March 2020 to December 2020. Assessments included: Montreal Cognitive Assessment-Blind, Hospital Anxiety and Depression Scale, Impact of Event Scale-6, EuroQOL 5 domain quality-of-life questionnaire, and components of the Multidimensional Dyspnea Profile. SETTING: Two tertiary academic health systems. PATIENTS: Of 173 eligible survivors, a random sample of 63 were contacted and 60 consented and completed interviews. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Mean age was 57 + 13 years and mean duration of invasive mechanical ventilation was 14 + 8.2 days. Six months post-discharge, 48 patients (80%; 95% CI, 68–88%) met criteria for post-intensive care syndrome (PICS), with one or more domains impaired. Among patients with PICS, 28 (47%; 95% CI, 35–59%) were impaired in at least 2 domains, and 12 (20%; 95% CI, 12–32%) impaired in all three domains. Significant symptoms of post-traumatic stress were present in 20 patients (33%; 95% CI, 23–46%), anxiety in 23 (38%; 95% CI, 27–51%), and depression in 25 (42%; 95% CI, 30–54%). Thirty-three patients (55%; 95% CI, 42–67%) had impairments in physical activity; 25 patients (42%; 95% CI, 30–54%) demonstrated cognitive impairment. CONCLUSIONS: Eighty percent of COVID-19 survivors who required mechanical ventilation demonstrated PICS 6 months after hospital discharge. Patients were commonly impaired in multiple PICS domains as well as coexisting mental health domains.

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Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months

Cited by 67 publications

References 48 publications

Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients

Symptom burden correlates to impairment of diffusion capacity and exercise intolerance in long COVID patients

Risk factors for impaired pulmonary diffusion function in convalescent COVID-19 patients: A systematic review and meta-analysis

Six-Month Impairment in Cognition, Mental Health, and Physical Function Following COVID-19–Associated Respiratory Failure

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