Severity of postgastrectomy syndrome and quality of life after advanced gastric cancer radical gastrectomy

Abstract

It has previously been suggested that postgastrectomy syndrome (PGS) is more severe in patients after surgery for advanced gastric cancer than in patients with early gastric cancer. Using the postgastrectomy syndrome assessment scale-45 (PGSAS-45), the present study aimed to determine whether PGS for postgastrectomy patients, in Kanazawa Medical University Hospital, with advanced gastric cancer was more severe than for patients with early gastric cancer. A questionnaire survey was conducted using PGSAS-45 for curative gastric cancer gastrectomy cases at Kanazawa Medical University Hospital. The questionnaire data were combined with patient background data, anonymized and moved to an unlinked file for patient privacy. Using this dataset, non-recurrent cases of distal partial gastrectomy were extracted and divided into two groups, stage IA or IB patients (group E), and stage IIA or higher (group A). The main outcome measures (MOMs) of PGSAS-45 were compared between the two groups. The participants in the present study included 35 cases in group E and 22 cases in group A. The results of a univariate analysis to compare the MOMs between the two groups showed that only the dumping subscale was significantly different in group A and was judged to be caused by the underlying bias of the background factor. There were no MOMs with significant differences in the pathological stage based on multiple regression analyses. In cases of distal partial gastrectomy, the PGS and quality of life (QoL) of patients following advanced gastric cancer surgery were similar to those of patients with early gastric cancer. The standardized treatment for advanced gastric cancer did not induce notable postoperative failures, and QoL was not impaired. In contrast, for early-stage gastric cancer cases, the present study suggests that it is necessary to distinguish metastasis-negative cases to indicate an appropriate, function-preserving curative gastrectomy.

Impact of Systematic Holistic Nursing Combined with Narrative Nursing Intervention for Patients with Advanced Gastric Cancer on Complications and Negative Emotions

“…Inclusion criteria: patients who were diagnosed with gastric cancer by tumor marker detection and pathological examination [9], with the TNM staging of stage III or IV, who met the indications for gastric cancer surgery [7], with stable vital signs after the surgery, without a history of other tumors, with a Karnofsky score of >60 points [10], and who had a detailed understanding of the main objectives of the study and the specific implementation needs of the study and provided written informed consent were included.…”

Health-Related Quality of Life in Locally Advanced Gastric Cancer: A Systematic Review

“…Kinami et al, also investigated long-term impacts on HRQOL (PGSAS-45) in patients who underwent a distal partial gastrectomy > 1 year ago. Locally advanced stage gastric cancer patients, in which the majority also received adjuvant chemotherapy before, showed similar HRQOL compared to early-stage gastric cancer (except for the dumping subscale which was found to be dependent on remnant stomach size) [ 32 ].…”

“…Second, there is also a difference in the quality of the included studies. Most studies are not randomized, and 4 of the 10 (40%) studies were scored as having “some concerns” in the Risk of Bias analysis [ 25 , 32 , 33 , 35 ].…”

A comparison of quality of life between patients with small and large gastric remnant volumes after gastrectomy for gastric cancer

“…Postgastrectomy syndrome includes the late postoperative complication that presents as the symptoms and signs, such as delayed gastric emptying, Roux stasis, dumping syndrome, bile reflux gastritis, postvagotomy diarrhea, and small gastric remnant syndrome [19–22] . The intractable symptoms from postgastrectomy syndrome can affect the QOL of gastrectomized patients [23,24] . Considering the recent number of early detections of GC through health screening systems and the increase in morbidly obese patients, interest in QOL is gradually increasing [2,25–27] …”

“…[19][20][21][22] The intractable symptoms from postgastrectomy syndrome can affect the QOL of gastrectomized patients. [23,24] Considering the recent number of early detections of GC through health screening systems and the increase in morbidly obese patients, interest in QOL is gradually increasing. [2,[25][26][27] Radical gastrectomy with sufficient lymph node dissection is necessary for the treatment of GC.…”