Severity of Pneumococcal Pneumonia Associated With Genomic Bacterial Load

Rello, Jordi; Lisboa, Thiago; Luján, Manel; Gallego, Miguel; Kee, Cordelia; Kay, Ian; López, Diego Pérez; Waterer, Grant

doi:10.1378/chest.09-0258

Cited by 198 publications

(149 citation statements)

References 25 publications

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“…We could not correlate DBL with mortality because none of our children died. Our data are in accordance with previous reports showing a relationship between DBL and worse outcome [34,10 ] and prolonged length of hospital stay [9] in patients with severe pneumococcal infections such as pneumonia and meningitis; as well as occurred in patients with meningococcal meningitis in whom there was an association between bacterial load and mortality, complications, sequelae and length of hospital stay [35].…”

Section: P=04)supporting

confidence: 93%

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DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema

Muñoz-Almagro

Gala

Selva

et al. 2010

Eur J Clin Microbiol Infect Dis

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Section: P=04)supporting

confidence: 93%

“…Moreover, Real-Time PCR may allow determining the quantification of pneumococcal DNA bacterial load (DBL) in different clinical samples and improving the management of patients with IPD as occur in some viral infections [9,10]. To our knowledge there are no reports about plasma and pleural fluid DBL in children with pneumonia and empyema.…”

Section: Introductionmentioning

confidence: 99%

DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema

Muñoz-Almagro

Gala

Selva

et al. 2010

Eur J Clin Microbiol Infect Dis

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“…This obstacle could potentially be overcome by the use of a quantitative PCR assay [17]. Rello et al reported that determination of bacterial load may increase the diagnosis of pneumococcal pneumonia and may be useful for severity assessment [18].…”

Section: Discussionmentioning

confidence: 99%

Bacterial and viral etiology in hospitalized community acquired pneumonia with molecular methods and clinical evaluation

Serin

Pullukçu

Çiçek

et al. 2014

J Infect Dev Ctries

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Introduction: Polymerase chain reaction (PCR) method has improved the diagnosis rates for patients with community-acquired pneumonia (CAP). We aimed to evaluate the bacterial and viral etiology of hospitalized CAP cases and compare clinical and laboratory findings of patients with pure bacterial and bacterial and viral (mixed) infections. Methodology: A total of 55 patients hospitalized with CAP were enrolled into the prospective study between February 2010 and December 2010. Clinical and laboratory follow-up were performed on days 0, 7 and 14. Deep tracheal aspiration samples were examined for bacterial and viral pathogens by multiplex PCR, and standard bacteriological culture method. Results: The etiological identification rate in 50 patients for bacteria, viruses and mixed virus-bacteria combination by PCR were 62%, 4%, 32%, respectively and 60% in 55 patients by bacterial culture method. Streptococcus pneumoniae concomitant with Haemophilus influenzae (36%) and rhinovirus (16%) was very common, whereas atypical pathogens (only Mycoplasma pneumoniae) were rare (6%). Rhinovirus was the most common viral agent (20%). Recently identified viruses, human coronavirus HKU1 and human bocavirus were not detected except for human metapneumovirus (one case). There was no significant difference in terms of mean age, immune status, leukocyte count, Creactive protein (CRP) values, hospitalization duration and CURB-65 score between bacterial and mixed viral-bacterial detections. Advanced age (p < 0.01) and higher CURB-65 score (p = 0.01) were found to be associated with increased mortality. Conclusion: Concomitance of bacterial and viral agents is frequent and resemble with bacterial infections alone. Further studies are needed for the clinical significance of mixed detections.

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“…Patients with ≥10 3 copies/ml of Streptococcus pneumoniae DNA in their blood were associated with higher risk for septic shock (OR=8.0), need for mechanical ventilation (OR=10.5) and hospital mortality (OR=5.43). (28) Whereas previous studies have suggested that severe sepsis is related to delay in therapy or an exaggerated host inflammatory response, this study suggests for the first time that insult, the bacterial burden, also plays a key role in development multiple organ dysfunction syndrome (MODS). In addition, there was recent demonstration of the correlation of bacterial load measured by quantitative tracheal aspirate (QTA) with serum CRP as an indicator of inflammatory response in episodes of ventilator-associated pneumonia and association of its variation with antibiotic appropriateness.…”

Section: Introductionmentioning

confidence: 75%

Entendendo o conceito PIRO: da teoria à prática clínica - Parte 1

Rabello¹,

Rosolem²,

Leal³

et al. 2009

Rev. bras. ter. intensiva

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Despite recent advances in diagnosis and care of critically ill patients sepsis related mortality rate remains unacceptably high. Therefore, new methods of evaluation are necessary to provide an earlier and more accurate characterization of septic patients. Based on the (oncologic) TNM system, the PIRO concept was introduced as a new staging system for sepsis in order to assess risk and predict prognosis, with potential to assist in inclusion of patients in clinical studies and estimate the probability of response of patients to specific therapeutic interventions.

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Severity of Pneumococcal Pneumonia Associated With Genomic Bacterial Load

Cited by 198 publications

References 25 publications

DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema

DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyema

Bacterial and viral etiology in hospitalized community acquired pneumonia with molecular methods and clinical evaluation

Entendendo o conceito PIRO: da teoria à prática clínica - Parte 1

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