Severity of Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation and an Oral Laser Phototherapy Protocol: A Survey of 30 Patients

Eduardo, Fernanda de Paula; Bezinelli, Letícia Mello; Luiz, Ana Cláudia; Corrêa, Luciana; Vogel, Cristina; Eduardo, Carlos

doi:10.1089/pho.2008.2225

Cited by 13 publications

(17 citation statements)

References 33 publications

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“…The use of therapeutic laser in the present study showed positive outcomes and the efficacy of laser to prevent and treat OM in patients subjected to HSCT, chemotherapy and radiotherapy, in accordance with data found in the literature (8,(11)(12)(13)(14)(15)(16)18,20) and the results were similar to those obtained by Antunes et al (12). The outcomes of the present study add to the evidence that therapeutic laser can be an effective option for the prevention and treatment of OM in patients subjected to HSCT with the absence of adverse effects or discomfort, as suggested by other authors (11,13).…”

Section: Discussionsupporting

confidence: 92%

“…nm (9), while current studies use several types of diodes such as the InGaAIP laser of 660 nm (18), the InGaAlP laser of 685 nm (14) and 660 nm (12), the GaAlAs laser of 830 nm (16). Eduardo et al (18) reported the use of a InGaAIP laser (660 nm) with 40 mW and energy density of 4 J/ cm 2 (for prevention of ulceration) or 6 J/cm 2 (for treatment of confirmed ulcerations) in 30 patients undergoing autologous (63.3%) or allogeneic (36.7%) HSCT.…”

Section: Discussionmentioning

confidence: 99%

“…Eduardo et al (18) reported the use of a InGaAIP laser (660 nm) with 40 mW and energy density of 4 J/ cm 2 (for prevention of ulceration) or 6 J/cm 2 (for treatment of confirmed ulcerations) in 30 patients undergoing autologous (63.3%) or allogeneic (36.7%) HSCT. The results showed improvement of OM after laser therapy.…”

Section: Discussionmentioning

confidence: 99%

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Use of therapeutic laser for prevention and treatment of oral mucositis

et al. 2009

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Oral mucositis (OM) affects patients who are submitted to hematopoietic stem cell transplantation (HSCT) due to high doses of chemotherapy and/or radiotherapy. The purpose of this investigation was to perform a comparative study of the frequency and evolution of OM among patients subjected to therapeutic laser and to the conventional therapy (use of mouthwash called "Mucositis Formula"). The patients were subjected to a myeloablative conditioning regimen before the allogeneic HSCT. Twenty-two patients were selected and divided into 2 groups: group I was irradiated with InGaAlP laser (660 nm) and GaAlAs laser (780 nm), 25 mW potency, 6.3J/ cm 2 dose, in 10-s irradiation time, followed to conventional treatment; group II was subjected only to the conventional treatment. Both World Health Organization (WHO) scale and the Oral Mucositis Assessment Scale (OMAS) were used to evaluate the results. Data were analyzed by the non-parametric Wilcoxon test, with p<0.05 considered as statistically significant. Group I presented a lower frequency of OM (p=0.02) and lower mean scores, according to WHO and OMAS scales (p<0.01 and p=0.01, respectively). In conclusion, laser reduced the frequency and severity of OM, suggesting that therapeutic laser can be used both as a new form of prevention and treatment of OM.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Use of therapeutic laser for prevention and treatment of oral mucositis

et al. 2009

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“…[3][4][5][6] Studies on the effects of LPT, either alone or in combination with other therapies, conducted in patients with immunosuppression, have shown that LPT promotes a reduction in pain intensity and mucositis severity, acceleration of wound healing, analgesic effects and an increase in the salivary flow rate, with no side effects. [3][4][7][8] Studies involving animal models allow a better understanding of the pathobiology of mucositis and a more in-depth evaluation of the effects of therapies for the prevention and treatment of this disease. The model for induced mucositis in hamsters was initially proposed by Sonis et al 9 and has proven useful in preclinical studies on new treatment options for mucositis.…”

Section: Introductionmentioning

confidence: 99%

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Lopez¹,

Martins²,

Pavesi

et al. 2013

Braz. oral res.

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The aim of this study was to investigate the effect of laser phototherapy (LPT) in the prevention and/or treatment of oral mucositis induced by 5-fluorouracil (5-FU; Eurofarma, São Paulo, Brazil) in hamsters. Ninety-six hamsters were divided into four groups (n = 24): Control (no treatment); Preventive [LPT from day (D) D−5 to D+5]; Therapeutic (LPT from D+5 to D+15); and Combined (preventive plus therapeutic LPT from D−5 to D+15). The animals received an intraperitoneal injection of 5-FU on Days 0 and 2. The pouch mucosa was scratched on Days 3 and 4. The irradiation parameters were: indium-gallium-aluminum-phosphide (InGaAlP) diode laser (MM Optics, São Carlos, Brazil) (660 nm), beam area of 0.036 cm², 40 mW, 1.11 W/cm², 6.6 J/cm², power density applied daily of 39.6 J/cm², in punctual mode (six points and six seconds per point) and contact mode, one application per day. The animals were sacrificed on Days 0, 5, 10 and 15 (n = 6) and weighed, and the pouch mucosa was removed for histopathological analysis. Clinical and corresponding histological scores were compared using ANOVA and Tukey's test (p ≤ 0.05). Similar weight losses ranging from 5% to 10% occurred in all groups. The therapeutic group had significantly lower clinical and histological scores than the other groups at Day 10. This study showed that positive effects on oral mucositis management were obtained only when LPT was applied in the therapeutic protocol (from D+5 to D+15 after chemotherapy).

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“…Les lasers hélium-néon (He/Ne, longueur d'ondes 632,8 nm) et à diode (longueur d'ondes 650 à 905 nm) sont les plus fréquemment rapportés dans ces indications, comme le laser InGaAIP de 660 nm [17] et 685 nm [18] et le laser GaAlAs de 830 nm [19]. Bien que l'intérêt du laser dans les mucites soit maintenant incontestable, la question de la puissance utilisée et du protocole fait actuellement débat.…”

Section: Commentairesunclassified

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

Lescaille

Lang

Ernenwein

et al. 2010

Med Buccale Chir Buccale

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Mots clés : mucite buccale / laser / douleur / cancers des voies aéro-digestivesRésumé -La mucite est une complication classique de la radiothérapie et/ou de la chimiothérapie dans le traitement des cancers des voies aéro-digestives supérieures. Sa prise en charge est avant tout symptomatique : prescription d'un traitement antalgique, topique et systémique. Depuis quelques années, l'utilisation de différents lasers s'est révélée particulièrement intéressante pour le traitement préventif et curatif des mucites radio et/ou chimio-induites. L'objectif de cet article est de faire le point sur les mécanismes d'action du laser de basse énergie et ses indications dans le traitement de lésions muqueuses spécifiques. Nous rapportons ici l'exemple d'un cas de mucite de grade 3 radio-induite chez un patient en cours de radiothérapie postopératoire pour un carcinome épidermoïde du rebord maxillaire. La prise en charge classique (soins locaux et antalgiques) a été mise en place, en association avec des séances de laser Nd :YAP (1,34 μm). Le retour à une toxicité muqueuse ≤ 2 et une cicatrisation de la plupart des zones ulcérées ont été observés dès la première semaine d'application. Parallèlement, un effet antalgique rapide était constaté avec une diminution de la douleur qui est passée de 90 à 30 sur l'EVA.Key words: oral mucositis / laser / pain / head and neck cancers Abstract -Lasers in the treatment of oral mucositis. Report of a case and review of littérature. The mucositis is a common complication of radiotherapy and/or chemotherapy in the treatment of head and neck cancers. Its management is symptomatic with topical and systemic analgesics. In recent years, the use of various lasers has proved particularly interesting for the preventive and curative treatment of mucositis induced by radiotherapy and chemotherapy. The aim of this article is to review the mechanisms of action of low energy laser and its indications in the treatment of mucosal lesion. We report here the case of mucositis grade 3 radiation-induced in a patient during postoperative radiotherapy for squamous cell carcinoma of the maxillary. Classical treatment (local care and analgesics) was set up in conjunction with sessions of Nd:YAP (1.34 mm). The return to ≤ 2 mucosal toxicity and scarring of the ulcerated areas were most observed in the first week of application. Meanwhile a rapid analgesic effect was observed with a decrease in pain that went from 90-30 on the VAS.La radiothérapie, exclusive ou postopératoire, occupe une place fondamentale dans le traitement des cancers des voies aéro-digestives supérieures. Dans les formes avancées, le bé-néfice d'une chimiothérapie concomitante à l'irradiation a été clairement démontré : elle permet d'améliorer le contrôle local

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Severity of Oral Mucositis in Patients Undergoing Hematopoietic Cell Transplantation and an Oral Laser Phototherapy Protocol: A Survey of 30 Patients

Abstract: The low grades of OM observed in this survey show the beneficial effects of laser phototherapy, but randomized clinical trials are necessary to confirm these findings.

Cited by 13 publications

References 33 publications

Use of therapeutic laser for prevention and treatment of oral mucositis

Use of therapeutic laser for prevention and treatment of oral mucositis

Effect of laser phototherapy in the prevention and treatment of chemo-induced mucositis in hamsters

Intérêt de la photothérapie au laser pour le traitement des mucites de la cavité buccale. Présentation d’un cas et revue de la littérature

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