Severity of Obstructive Sleep Apnea Related to Aldosterone Levels in Subjects With Resistant Hypertension: PP.32.274

Gonzaga, Carolina C.; Ac, Cordeiro; Lotaif, Leda; Sousa, M. G.; Passarelli, Oswaldo; Borelli, Fao; Amodeo, Celso; Sousa, A

doi:10.1097/01.hjh.0000379812.66839.11

Cited by 34 publications

(46 citation statements)

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“…In one study of 109 patients with resistant hypertension, OSA was found in 84% of patients with PA, supporting the concept that in subjects with resistant hypertension, the severity of OSA is greater in those patients with hyperaldosteronism and correlates with the degree of aldosterone access [12]. In another study …”

Section: Discussionmentioning

confidence: 58%

“…PA also overlapped with MS and OSA [6]. Because the coexistence of PA and OSA in patients with resistant hypertension has been reported only by a few authors, we analysed the relationship between PA and OSA, metabolic abnormalities and cardiac structure in patients with true resistant hypertension enrolled in the RESIST-POL Study [6,11,12].…”

Section: Introductionmentioning

confidence: 99%

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Relationship between primary aldosteronism and obstructive sleep apnoea, metabolic abnormalities and cardiac structure in patients with resistant hypertension

Prejbisz¹,

Florczak²,

Klisiewicz³

et al. 2013

Endokrynologia Polska

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Section: Discussionmentioning

confidence: 58%

Section: Introductionmentioning

confidence: 99%

Relationship between primary aldosteronism and obstructive sleep apnoea, metabolic abnormalities and cardiac structure in patients with resistant hypertension

Prejbisz¹,

Florczak²,

Klisiewicz³

et al. 2013

Endokrynologia Polska

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“…A SAOS tem sido reconhecida ainda como a principal causa secundária de hipertensão arterial resistente pelas diretrizes europeias e americanas e pela VI Diretriz Brasileira de Hipertensão Arterial 24 . Estudos investigam o papel do hiperaldosteronismo como importante ponte dessa relação, principalmente na SAOS grave, com resultados promissores do uso de antagonista da aldosterona nessa população 25,26 .…”

Section: Hipertensão Arterial Sistêmicaunclassified

Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares

Campostrini

Prado

2014

RNC

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RESUMOIntrodução. A Síndrome da Apneia Obstrutiva do Sono (SAOS) é caracterizada por obstrução parcial ou completa da via aérea superior, de forma intermitente e recorrente durante o sono. As principais manifestações durante o sono incluem roncos, pausas respiratórias, fragmentação do sono, levando a prejuízos diurnos incapacitantes, como sonolência excessiva diurna, alterações cognitivas e cefaléia matinal. Além das manifestações respiratórias clássicas, resulta em alterações metabólicas e hemodinâmicas que predispõem ao desenvolvimento e agravamento de doenças cardiovasculares, tais como hipertensão arterial sistêmica, insuficiência cardíaca congestiva, doença arterial coronariana e arritmias. Objetivo. Abordar aspectos clínicos, fisiopatológicos e diagnósticos da SAOS, bem como seus efeitos deletérios no sistema cardiovascular. Método. Revisão da literatura acerca da SAOS e suas consequências cardiovasculares através de artigos selecionados no PubMed. Conclusão. A apneia obstrutiva do sono e as doenças cardiovasculares têm origem multifatorial e alta prevalência na população mundial. Considerando que as doenças cardiovasculares são a maior causa atual de morbidade e mortalidade no mundo, a determinação de fatores de risco possíveis de controle e tratamento, como a SAOS, torna-se fundamental para prevenção e tratamento das doenças cardiovasculares.Unitermos. Síndrome da Apneia Obstrutiva do Sono, Doenças Cardiovasculares, Hipertensão, insuficiência Cardíaca Congestiva, Doença da Artéria Coronariana, Arritmias Cardíacas.Citação. Campostrini DDA, Prado LBF, Prado GF. Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares. ABSTRACTIntroduction. Obstructive Sleep Apnea Syndrome (OSAS) is characterized by partial or complete obstruction of the upper airway, intermittently and recurrently during sleep. The main manifestations during sleep include snoring, pauses in breathing, sleep fragmentation, resulting in excessive daytime sleepiness, cognitive dysfunction and morning headaches. Besides the classic respiratory symptoms, OSAS results in metabolic and hemodynamic alterations that predispose to the development and worsening of cardiovascular diseases such as hypertension, congestive heart failure, coronary artery disease and arrhythmias. Objective. Reporting clinical, pathophysiological and diagnostic aspects of OSAS and its deleterious effects on the cardiovascular system. Method. Review of literature about OSAS and its cardiovascular consequences through selected articles in PubMed. Conclusion. Obstructive sleep apnea and cardiovascular diseases have multifactorial origin and high prevalence in the global population. Because cardiovascular diseases are the main cause of the current morbidity and mortality worldwide, determining possible treatable risk factors, such as OSAS, it is fundamental to prevention and treatment of cardiovascular diseases.

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“…60 Among subjects with resistant hypertension, a significant prevalence of aldosteronism can be observed, that reaches 28%. 20,67,68 In individuals with resistant hypertension, aldosterone excess promotes greater fluid retention, worsening OSA severity. On the other hand, OSA may further increase sympathetic nervous and renin-angiotensin- …”

Section: Aldosterone and Fluid Retentionmentioning

confidence: 99%

“…7,[17][18][19] When resistant hypertension is considered, the prevalence of OSA increases up to 64%-83%, depending on the AHI considered for the diagnosis. [20][21][22][23] Diurnal hypersomnia due to frequent nocturnal arousals, asthenia, snoring, and witnessed apnea are the main symptoms of OSA. When OSA is suspected, the Epworth Sleepiness Scale or the Berlin Questionnaire could be used respectively to measure daytime sleepiness and to identify patients at higher risk for OSA.…”

Section: Introductionmentioning

confidence: 99%

Cardiac function and hypertension in patients with obstructive sleep apnea

Bertolami¹,

Gonzaga²,

Amodeo³

2014

RRCC

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Cardiovascular disease is one of the major causes of death worldwide. Among its risk factors, obstructive sleep apnea (OSA) is a common but still underestimated condition. OSA often coexists and interacts with obesity, sharing multiple pathophysiological mechanisms and subsequent cardiovascular risk factors, such as type 2 diabetes, dyslipidemia, systemic inflammation, and in particular hypertension. There is also evidence suggesting an increased risk of arrhythmia, heart failure, renal failure, acute myocardial infarction, stroke, and death. OSA is characterized by recurrent episodes of partial (hypopnea) or complete interruption (apnea) of breathing during sleep due to airway collapse in the pharyngeal region. The main mechanisms linking OSA to impaired cardiovascular function are secondary to hypoxemia and reoxygenation, arousals, and negative intrathoracic pressure. Consequently, the sympathetic nervous and the renin-angiotensin-aldosterone systems may be overestimulated, and blood pressure increased. Resistance to treatment for hypertension represents a growing issue, and given that OSA has been recognized as the major secondary cause of resistant hypertension, clinical investigation for apnea is mandatory in this population. Standard diagnosis includes polysomnography, and treatment for OSA should include control of risk factors for cardiovascular disease, including obesity. So far, continuous positive airway pressure is the treatment of choice for OSA, impacting positively on blood pressure goals; however, the impact on long-term follow-up and on cardiovascular disease should be better assessed.

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Severity of Obstructive Sleep Apnea Related to Aldosterone Levels in Subjects With Resistant Hypertension: PP.32.274

Cited by 34 publications

References 0 publications

Relationship between primary aldosteronism and obstructive sleep apnoea, metabolic abnormalities and cardiac structure in patients with resistant hypertension

Relationship between primary aldosteronism and obstructive sleep apnoea, metabolic abnormalities and cardiac structure in patients with resistant hypertension

Síndrome da Apneia Obstrutiva do Sono e Doenças Cardiovasculares

Cardiac function and hypertension in patients with obstructive sleep apnea

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