Severity of alcoholism in Indian males: Correlation with age of onset and family history of alcoholism

Johnson, Pradeep R; Banu, Saira; Mysore, Ashok

doi:10.4103/0019-5545.70977

Cited by 25 publications

(20 citation statements)

References 36 publications

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“…When age of onset of drinking was analyzed in relation to family history, it was found that family history of alcohol consumption was significantly associated with age at initiation of drinking (p < 0.05). The finding of this study is in agreement with the findings of Sarkar AP et al [13] and Pradeep RJ et al [14]. The most common type of alcohol consumed by the study subjects in the present study was brandy, followed by toddy.…”

Section: Discussionsupporting

confidence: 93%

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A study on socio-demographic factors of alcoholics attending a deaddiction centre in Kannur district

Mohandas

Vivek²,

Ratheesh

et al. 2019

Public Health Rev: Int J Public Health Res

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Background: Alcoholism is a major public health problem in Kerala. It leads to serious social, mental and physical consequences. Method: A deaddiction centre based cross sectional study was done on 370 individuals using a predesigned questionnaire during the period of 2012-2013. The data was analyzed using SPSS version 17. Chi-Square test was used to find association between the study variables. Results: The study was done on 370 alcohol dependent subjects. The mean age of the study subjects was 38.08±8.46 years. 64.3% of the study subjects were from rural areas. The mean age of starting alcohol consumption was 25.46±6.6 years. Family history of alcohol consumption was present in 99 (26.8%) patients. The age at initiation of alcohol intake was significantly (p < 0.05) associated with family history. The mean duration of drinking was 12.62±7.47 years. 42.4% of the study subjects consumed brandy. 37.6% of them consumed < 200ml of alcohol per day. Peer pressure was the most common reason cited by 44.1% individuals for starting alcohol consumption. The most common reason cited by 30.5% individuals for continuing alcohol consumption was because they liked its effect. Family problems and financial problems were the most common reasons cited wanting to stop alcohol consumption. Conclusion: Alcohol use is a serious public health problem. Awareness programs regarding its harmful use should be given to the people in the community.

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Section: Discussionsupporting

confidence: 93%

“…The mean age of starting alcohol consumption was 25.46±6.6 years in the present study. But it was slightly lower in the study done by Pradeep RJ et al where it was 21.39±5.34 years [14].…”

Section: Discussionmentioning

confidence: 59%

A study on socio-demographic factors of alcoholics attending a deaddiction centre in Kannur district

Mohandas

Vivek²,

Ratheesh

et al. 2019

Public Health Rev: Int J Public Health Res

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“…High anxiety levels, family history (FH) positive for alcoholism and early onset of alcoholism (EOA) have been correlated with the severity of alcoholism (e.g. Johnson et al, 2010; Gleeson et al, 2009; Leggio et al, 2009); therefore these factors were explored as potential moderators of baclofen’s response. Additionally, we attempted to explore possible genetic moderators with the overall goal to provide very preliminary information that might guide possible fully-powered studies.…”

Section: Introductionmentioning

confidence: 99%

A human laboratory pilot study with baclofen in alcoholic individuals

Leggio

Zywiak

McGeary

et al. 2013

Pharmacology Biochemistry and Behavior

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Preclinical and clinical studies show that the GABAB receptor agonist baclofen may represent a pharmacotherapy for alcohol dependence (AD). However, the mechanisms by which baclofen affects drinking are not well characterized; thus this pilot study investigated possible baclofen’s biobehavioral mechanisms. The design was a double-blind controlled randomized human laboratory pilot study. Fourteen non-treatment seeking alcohol-dependent heavy drinking subjects received either baclofen 10 mg t.i.d. or an active placebo (cyproheptadine 2 mg t.i.d., to control for sedation) for a 7-day period. At day 8, participants performed an alcohol cue-reactivity (CR) followed by an alcohol self-administration (ASA). Additionally, we explored possible moderators that might guide future larger studies, i.e. anxiety, family history and onset of alcoholism, and D4 dopamine receptor (DRD4) and 5-HTTLPR polymorphisms. The main results were a significant effect of baclofen for increasing stimulation (p=.001) and sedation (p<.01). Furthermore, when drinking during the ASA and the 2 days before was analyzed as a composite variable, there was a significant effect of baclofen to reduce alcohol consumption (p<.01). As for the exploratory analyses, baclofen’s effects to increase alcohol sedation and to reduce alcohol consumption were limited to those individuals with DRD4 ≥7 repeats (DRD4L). Yet, baclofen’s effects on alcohol consumption were also moderated by 5-HTTLPR LL genotype. In conclusion, baclofen’s ability to reduce alcohol drinking may be related to its effects on the biphasic effects of alcohol, but larger studies are needed to confirm these preliminary findings.

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“…In India Alcohol Use Disorder Identification Test (AUDIT),[ 1 ] CAGE,[ 2 ] and Michigan Alcoholism Screening Test (MAST)[ 3 ] have been commonly used. [ 4 5 6 7 ]…”

Section: Introductionmentioning

confidence: 99%

“…[ 9 ] The questionnaire method has depended on Severity of Alcohol Dependence Data (SADD)[ 5 ] and Severity of Alcohol Dependence Questionnaire (SADQ). [ 7 10 ]…”

Section: Introductionmentioning

confidence: 99%

Do SADQ and AUDIT identify independent impacts of alcohol abuse - clinical and biochemical markers respectively?

Pradeep

Andrew

Mysore

2015

Indian J Psychiatry

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Background and Objectives:We have analyzed extant data to see if Alcohol Use Disorder Identification Test (AUDIT) and Severity of Alcohol Dependence Questionnaire (SADQ) assess overlapping aspects of alcoholism, and how they relate to lab measures of alcoholism.Materials and Methods:Consecutive male patients between 20 and 50 years were recruited from varied departments of a general hospital. AUDIT and SADQ, as well as liver function tests, were part of the data obtained.Results:Despite, a significant correlation between total scores of SADQ and AUDIT (ρ = 0.188, P < 0.021) and some of their sub-scores. SADQ scores alone were significantly correlating with clinical variables of alcoholism such as family history and age of onset; AUDIT did not. On the other hand, AUDIT total scores correlated with total and conjugated bilirubin, while SADQ did not.Interpretation and Conclusion:Our data suggests that the two scales, AUDIT and SADQ may be tapping into two different outcomes of increased alcohol use namely clinical and biochemical markers, respectively. SADQ could be useful in studies looking at withdrawal related severity and clinical aspects of alcoholism; while AUDIT could be more suitable for studies looking at alcoholism-related medical morbidity. This needs to be confirmed in larger unselected samples from different community and clinical settings.

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Severity of alcoholism in Indian males: Correlation with age of onset and family history of alcoholism

Cited by 25 publications

References 36 publications

A study on socio-demographic factors of alcoholics attending a deaddiction centre in Kannur district

A study on socio-demographic factors of alcoholics attending a deaddiction centre in Kannur district

A human laboratory pilot study with baclofen in alcoholic individuals

Do SADQ and AUDIT identify independent impacts of alcohol abuse - clinical and biochemical markers respectively?

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