Severity of alcohol dependence and mortality after 20 years in an adult general population sample

John, Ulrich; Rumpf, Hans‐Jürgen; Hanke, Monika; Meyer, Christian

doi:10.1002/mpr.1915

Cited by 8 publications

(4 citation statements)

References 33 publications

(42 reference statements)

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“…This rate is almost equal to the proportion of smokers that has been reported among patients receiving treatment for alcohol dependence [5]. The percentage in our sample seems very high since it may be assumed that treatment is utilized predominantly by severely dependent individuals [22]. In addition, our data revealed a dose-dependent relation between risky alcohol drinking and the proportion of current smokers.…”

Section: Discussionsupporting

confidence: 54%

Alcohol and Nicotine Dependence and Time to Death in a General Adult Population: A Mortality Cohort Study

John,

Rumpf,

Hanke

et al. 2023

Eur Addict Res

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Introduction: Findings from general population studies are lacking in regard to the co-occurrence of alcohol and nicotine dependence in relation to later mortality. The aim of this study was to analyze potential interactions of risky alcohol drinking, tobacco smoking, alcohol and nicotine dependence, and time until the first cigarette is smoked in the morning after awakening in the prediction of mortality. Methods: This study analyzed a random sample of the general population in Northern Germany, which comprised adults aged 18–64 years. Risky alcohol drinking, tobacco smoking, alcohol and nicotine dependence, and the time until the first cigarette in the morning after awakening were assessed for the period of 1996–1997 by applying the Munich-Composite International Diagnostic Interview. Data about all-cause mortality were gathered for the period of 2017–2018 and analyzed using Cox proportional hazards models. Results: Risky alcohol drinking, tobacco smoking, alcohol and nicotine dependence, and the time until the first cigarette in the morning were associated with each other and predicted the time to death. Among participants with a former alcohol dependence, 29.59% had a current nicotine dependence. Participants who had ever been dependent on alcohol at some point in their life before and currently smoked their first cigarette in the morning within 30 min or less after awakening had a hazard ratio of 5.28 (95% confidence interval: 3.33–8.38) for early death compared to low-risk alcohol consumers who had never smoked. Conclusion: Risky alcohol drinking, tobacco smoking, alcohol and nicotine dependence, and the time until the first cigarette in the morning may have a cumulative impact on time to death. The findings suggest that it could be beneficial to provide support for quitting both risky alcohol drinking and tobacco smoking among nondependent individuals in addition to supporting remission from dependence.

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Section: Discussionsupporting

confidence: 54%

Alcohol and Nicotine Dependence and Time to Death in a General Adult Population: A Mortality Cohort Study

John,

Rumpf,

Hanke

et al. 2023

Eur Addict Res

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“…Approximately 56% of deaths were premature (before age 75) [7]. Most of the health burden related to excessive alcohol drinking, specifically deaths, affects individuals suffering from severe AUD [8]. No doubt, the consequences of harmful alcohol consumption on human health are remarkable.…”

Section: Introductionmentioning

confidence: 99%

Neurotensin and Alcohol Use Disorders: Towards a Pharmacological Treatment

Rodríguez

Sánchez

Coveñas

2023

IJMS

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Harmful alcohol use is responsible for a group of disorders collectively named alcohol use disorders (AUDs), according to the DSM-5 classification. The damage induced by alcohol depends on the amount, time, and consumption patterns (continuous and heavy episodic drinking). It affects individual global well-being and social and familial environments with variable impact. Alcohol addiction manifests with different degrees of organ and mental health detriment for the individual, exhibiting two main traits: compulsive drinking and negative emotional states occurring at withdrawal, frequently causing relapse episodes. Numerous individual and living conditions, including the concomitant use of other psychoactive substances, lie in the complexity of AUD. Ethanol and its metabolites directly impact the tissues and may cause local damage or alter the homeostasis of brain neurotransmission, immunity scaffolding, or cell repair biochemical pathways. Brain modulator and neurotransmitter-assembled neurocircuitries govern reward, reinforcement, social interaction, and consumption of alcohol behaviors in an intertwined manner. Experimental evidence supports the participation of neurotensin (NT) in preclinical models of alcohol addiction. For example, NT neurons in the central nucleus of the amygdala projecting to the parabrachial nucleus strengthen alcohol consumption and preference. In addition, the levels of NT in the frontal cortex were found to be lower in rats bred to prefer alcohol to water in a free alcohol–water choice compared to wild-type animals. NT receptors 1 and 2 seem to be involved in alcohol consumption and alcohol effects in several models of knockout mice. This review aims to present an updated picture of the role of NT systems in alcohol addiction and the possible use of nonpeptide ligands modulating the activity of the NT system, applied to experimental animal models of harmful drinking behavior mimicking alcohol addiction leading to health ruin in humans.

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“…Substanzbezogene Störungen insgesamt und speziell alkoholbezogene Störungen gehören nicht nur zu den häufigsten psychischen Störungen [1] [2], sondern gehen mit einer um ca. 20 Jahre gegenüber der Allgemeinbevölkerung verkürzten Lebenserwartung einher [3]. Seit Anfang der 1990er-Jahre ist zudem bekannt, dass ca.…”

Section: Introductionunclassified

Lost in System Gaps – Versorgungslücken bei Suchtkranken und deren Auswirkungen

Reker,

Driessen

2023

PiD - Psychotherapie im Dialog

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Zahlreiche Suchtkranke werden vom Hilfesystem nicht erreicht, insbesondere bei schweren Krankheitsverläufen, komorbiden Störungen und/oder sozialer bzw. beruflicher Desintegration. Die Hintergründe dafür sind vielfältig. Das Versorgungssystem steht vor der Herausforderung, den suchtspezifischen Kompetenzerwerb zu fördern und sich konzeptuell stärker an der Lebenswelt und dem Bedarf der Betroffenen zu orientieren.

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Severity of alcohol dependence and mortality after 20 years in an adult general population sample

Cited by 8 publications

References 33 publications

Alcohol and Nicotine Dependence and Time to Death in a General Adult Population: A Mortality Cohort Study

Alcohol and Nicotine Dependence and Time to Death in a General Adult Population: A Mortality Cohort Study

Neurotensin and Alcohol Use Disorders: Towards a Pharmacological Treatment

Lost in System Gaps – Versorgungslücken bei Suchtkranken und deren Auswirkungen

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