Severity and Outcomes of Dengue in Hospitalized Jamaican Children in 2018–2019 During an Epidemic Surge in the Americas

Lue, Aileen May; Richards-Dawson, Michelle-Ann; Gordon‐Strachan, Georgiana; Kodilinye, Syed Matthew; Dunkley-Thompson, Jacqueline Anne Theresa; James-Powell, T; Pryce, Curtis Alphonso; Mears, Chadwic De'sean; Anzinger, Joshua J.; Webster-Kerr, Karen; Christie, Celia D. C.

doi:10.3389/fmed.2022.889998

Cited by 10 publications

(13 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

Section: Denguementioning

confidence: 99%

“…Children are significantly affected by dengue fever epidemics within the Caribbean [ 16 , 17 , 18 ▪▪ , 19 – 23 , 24 ▪ ]. Jamaica has reported trends of dengue in children over the years [ 16 , 18 ▪▪ , 19 – 21 , 24 ▪ ]. During the 2018–2019 epidemic, Jamaican children were most significantly affected with increased attributable morbidity and mortality [ 16 , 18 ▪▪ , 24 ▪ ].…”

Section: Denguementioning

confidence: 99%

“…Jamaica has reported trends of dengue in children over the years [ 16 , 18 ▪▪ , 19 – 21 , 24 ▪ ]. During the 2018–2019 epidemic, Jamaican children were most significantly affected with increased attributable morbidity and mortality [ 16 , 18 ▪▪ , 24 ▪ ]. Those under 15 years of age represented 41% of the total reported 10 411 cases and 42% of those who were hospitalized [ 16 ].…”

Section: Denguementioning

confidence: 99%

See 2 more Smart Citations

Dengue, chikungunya and zika arbovirus infections in Caribbean children

Christie

Lue²,

Melbourne-Chambers

2023

Current Opinion in Pediatrics

View full text Add to dashboard Cite

Purpose of reviewDengue, chikungunya and zika have caused significant epidemics in the Caribbean in recent years. This review highlights their impact in Caribbean children.Recent findingsDengue has been increasingly intense and severe, seroprevalence is 80–100% in the Caribbean, children have increased attributable morbidity and mortality. Severe dengue, especially dengue with haemorrhage was significantly associated with haemoglobin SC disease and multiple organ-systems involved. These included the gastrointestinal and haematologic systems with extremely high lactate dehydrogenases and creatinine phosphokinases and severely abnormal bleeding indices. Despite appropriate interventions, mortality was highest within the first 48 h of admission. Chikungunya, a togavirus, affected 80% of some Caribbean populations. Paediatric presentations included high fever, skin, joint and neurological manifestations. Children less than 5 years of age had the highest morbidity and mortality. This maiden chikungunya epidemic was explosive and overwhelmed public health systems. Zika, another flavivirus, has a seroprevalence of 15% in pregnancy, so the Caribbean remains susceptible. Paediatric complications include pregnancy losses, stillbirths, Congenital Zika syndrome, Guillain–Barre syndrome, acute disseminated encephalomyelitis and transverse myelitis. Neurodevelopment stimulation programs for zika-exposed infants have been effective in improving language and positive behaviour scores.SummaryCaribbean children remain at risk for dengue, chikungunya and zika, with high attributable morbidity and mortality.

show abstract

Section: Denguementioning

confidence: 99%

Section: Denguementioning

confidence: 99%

Section: Denguementioning

confidence: 99%

See 1 more Smart Citation

Dengue, chikungunya and zika arbovirus infections in Caribbean children

Christie

Lue²,

Melbourne-Chambers

2023

Current Opinion in Pediatrics

View full text Add to dashboard Cite

show abstract

“…Jamaica has experienced several DENV outbreaks of increasing intensity, severity, and magnitude in recent years (2010, 2012, and 2018-2019), with increased attributable morbidity and mortality in the very young, including reported cases of neonatal microcephaly [11][12][13][14]. Jamaica also experienced an explosive CHIKV epidemic in 2014 [3,[15][16][17][18]: >80% of the general and antenatal populations were affected, with significant perinatal (maternal and newborn) illnesses, increased attributable neonatal morbidity and mortality [3,16,19], and >2500 deaths during the epidemic year nationally [18].…”

Section: Introductionmentioning

confidence: 99%

Detection of Potential Arbovirus Infections and Pregnancy Complications in Pregnant Women in Jamaica Using a Smartphone App (ZIKApp): Pilot Evaluation Study

Ruiz-Burga¹,

Bruijning-Verhagen²,

Palmer³

et al. 2022

JMIR Form Res

View full text Add to dashboard Cite

Background There is growing evidence of the benefits of mobile health technology, which include symptom tracking apps for research, surveillance, and prevention. No study has yet addressed arbovirus symptom tracking in pregnancy. Objective This study aimed to evaluate the use of a smartphone app (ZIKApp) to self-report arbovirus symptoms and pregnancy complications and to assess compliance with daily symptom diaries during pregnancy in a cohort of women in an arbovirus-endemic, subtropical, middle-income country (Jamaica). Methods Pregnant women aged ≥16 years, having a smartphone, and planning on giving birth at the recruiting center were enrolled between February 2020 and July 2020. ZIKApp comprised a daily symptom diary based on algorithms to identify potential episodes of arbovirus infection and pregnancy complications. Sociodemographic, epidemiological, and obstetric information was collected at enrollment, with additional review of medical records, and users’ perception was collected through an exit survey. Descriptive analyses and logistic regression analysis of possible factors associated with diary adherence were performed. Results Of the 173 women enrolled, 157 (90.8%) used ZIKApp for a median duration of 155 (IQR 127-173) days until pregnancy end, 6 (3.5%) used the app for <7 days, and 10 (5.8%) exited the study early. For each successive 30-day period from enrollment up to 150 days after enrollment, of these 157 women, 121 (77.1%) to 129 (82.2%) completed their daily symptom diary; 50 (31.8%) to 56 (35.7%) did so on the same day. Overall, 31.8% (50/157) of the women had good adherence to diary reporting (ie, they completed the task on the same day or 2 to 3 days later for ≥80% of the days enrolled). There were 3-fold higher odds of good adherence for participants aged >34 years versus those aged 25 to 29 years (adjusted odds ratio 3.14, 95% CI 1.10-8.98) and 2-fold higher odds for women with tertiary versus secondary education (adjusted odds ratio 2.26, 95% CI 1.06-4.83). Of the 161 women who ever made a diary entry, 5454 individual symptom reports were made (median 17 per woman; IQR 4-42; range 0-278); 9 (5.6%) women reported symptom combinations triggering a potential arbovirus episode (none had an adverse pregnancy outcome) and 55 (34.2%) reported painful uterine contractions or vaginal bleeding, mainly in the month before delivery. Overall, 51.8% (71/137) of the women rated the app as an excellent experience and were less likely to be poor diary adherers (P=.04) and 99.3% (138/139) reported that the app was easy to understand and use. Conclusions This pilot found a high adherence to ZIKApp. It demonstrated the feasibility and usability of the app in an arbovirus-endemic region, supporting its future development to contribute to surveillance and diagnosis of arbovirus infections in pregnancy and to optimize maternal care.

show abstract

“…Several markers including sickle cell disease (haemoglobin SC and SS), change in haematological parameters (decreased platelets, leucopenia), elevated levels of hepatic enzymes (transaminases, creatine kinase) have been associated with dengue haemorrhagic fever, dengue shock and mortality [12][13][14][15][16][17]. However, reliable predictive biomarkers of cardiac impairment as predictor of SD are lacking and remains a challenge in the clinical management of febrile dengue patients.…”

Section: Introductionmentioning

confidence: 99%

Clinical and prognostic relevance of sST2 in adults with dengue-associated cardiac impairment and severe dengue

Teo

Chia²,

Ramireddi³

et al. 2022

PLoS Negl Trop Dis

View full text Add to dashboard Cite

Background Dengue can be complicated by severe outcomes including cardiac impairment, and the lack of reliable prognostic biomarkers poses a challenge in managing febrile dengue patients. Here, we investigated the functionality of soluble suppressor of tumorigenicity (sST2) as a predictive marker of severe dengue and its association in dengue-associated cardiac impairment. Methods Plasma samples, aged >16 years, collected from 36 dengue fever, 43 dengue with warning signs, 11 severe dengue (collected at febrile, critical and recovery phases) and 30 controls were assayed for plasma levels of sST2, troponin T and N-terminal (NT)-pro hormone brain natriuretic peptide (NT-proBNP) by ELISA. Cardiac parameters: stroke index (SI), cardiac index (CI) and Granov-Goor Index (GGI) were measured with a bioimpedance device during the different phases for dengue subjects and once for the controls. Principal findings In the febrile, critical and early recovery phases, sST2 levels were significantly elevated in dengue participants and sST2 levels increased with increasing disease severity (P < 0.01 for all). sST2 concentrations were negatively correlated with SI (r = -0.48; P < 0.001, r = -0.55; P < 0.001), CI (r = -0.26; P = 0.02, r = -0.6: P < 0.001) and GGI (r = -0.44; P < 0.001, r = -0.57; P < 0.001) in the critical and early recovery phases. In contrast, sST2 levels in the febrile and critical phases, were positive correlated to troponin T (r = 0.44, P < 0.001; r = 0.22, P = 0.03, respectively) and NT-proBNP (r = 0.21, P = 0.03; r = 0.35, P < 0.001). ROC analysis demonstrated sST2 as a good biomarker of severe dengue in the critical phase, AUROC 0.79, P < 0.001. Conclusion/Significance sST2 levels were elevated in patients with dengue especially in cases of severe dengue. Furthermore, increased sST2 levels were associated with cardiac indicators suggesting lower cardiac performance. While further research is needed to demonstrate its clinical utility, sST2 may be a useful prognostic biomarker of severe dengue.

show abstract

Severity and Outcomes of Dengue in Hospitalized Jamaican Children in 2018–2019 During an Epidemic Surge in the Americas

Cited by 10 publications

References 33 publications

Dengue, chikungunya and zika arbovirus infections in Caribbean children

Dengue, chikungunya and zika arbovirus infections in Caribbean children

Detection of Potential Arbovirus Infections and Pregnancy Complications in Pregnant Women in Jamaica Using a Smartphone App (ZIKApp): Pilot Evaluation Study

Clinical and prognostic relevance of sST2 in adults with dengue-associated cardiac impairment and severe dengue

Contact Info

Product

Resources

About