Severity and Management of Drug–Drug Interactions in Acute Geriatric Patients

Lea, Marianne; Rognan, Stine Eidhammer; Koristovic, Radojka; Wyller, Torgeir Bruun; Molden, Espen

doi:10.1007/s40266-013-0091-y

Cited by 23 publications

(29 citation statements)

References 96 publications

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“…In this study, 62.2 % of the respondents were exposed to at least one potential DDI [including contraindicated (3.6 %), major (32.9 %) and moderate (25.7 %)]. The prevalence of major and moderate DDI in the current study is in line with the findings by Luca et al [31] and Lea et al [32], which reported a prevalence of 63.5, 60.5 % potential DDIs respectively. In contrast to this study, lower prevalence of DDIs was reported from other studies focusing on elderly outpatients [33–35].…”

Section: Discussionsupporting

confidence: 93%

Potential drug–drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

et al. 2016

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BackgroundThe elderly are considered as special population, as they differ from younger adults in terms of comorbidity, polypharmacy, pharmacokinetics, vulnerability to drug–drug interactions and adverse drug reactions. Despite the fact that the elderly patients are at high risk of having drug interaction and potential adverse outcomes, studies in this regard are scarce in resource limited settings like Ethiopia. The aim of this study was to assess the prevalence and determinants of potential drug–drug interaction in elderly patients admitted to medical ward of Ayder Referral Hospital in Northern Ethiopia.MethodsA cross sectional study was conducted among elderly inpatients aged 60 years and above. The study was conducted from February to May 2014. Prescribed drugs being taken concurrently for at least 24 h were included and checked for drug–drug interaction using Micromedex® 2.0 online drug reference. Data were analyzed using statistical software, statistical package for social sciences for windows version 20. Logistic regression model was used to analyze factors associated with occurrence of drug interaction. P value of <0.05 was considered statistically significant.ResultsA total of 140 patients were participated in the study. The mean age (±standard deviation) of participants was 68 (±7) years. Majority (61.4 %) of patients were diagnosed with cardiovascular and/or renal diseases. A total of 814 drugs were prescribed with a mean of 6 (±4) medications per patient during a 13 (±9) days of hospital stay. About two-third (62.2 %) of the respondents were exposed to at least one potential drug–drug interaction. Among these 3.6, 32.9 and 25.7 % of patients had taken contraindicated drug combination, at least one major and at least one moderate drug–drug interaction, respectively. Patients with five or more prescribed medications were four times at risk of having drug–drug interaction (P = 0.00; adjusted odds ratio 4.047; 95 % confidence interval 1.867–8.775).ConclusionDrug–drug interaction in elderly patients was common in this resource limited set-up. Awareness creation and clinical pharmacist involvement in minimizing the risk associated with potentially harmful drug combinations are needed.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-016-2238-5) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 93%

Potential drug–drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

et al. 2016

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“…O medicamento contribui para a melhoria da qualidade de vida do idoso, mas pode, também, causar eventos adversos que levam a danos, alguns deles determinados por interações medicamentosas. O consumo de múltiplos medicamentos contribui para a ocorrência de interações medicamentosas não desejáveis 7,[15][16][17] .…”

Section: Resultsunclassified

Interações medicamentosas em prescrições de idosos hipertensos: prevalência e significância clínica

Pinto¹,

Vieira

Pereira³

et al. 2014

Rev. enferm. UERJ

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“…The patients included in this study had the burden of psychiatric disorders and other comorbidities associated with the negative con- The present study showed that the prevalence of potential DDIs was associated with the number of administered drugs. The number of medications has been shown to be a predictive factor for the occurrence of DDIs in elderly patients subjected to pharmacotherapy (Lao et al, 2013;Lea et al, 2013;Mibielli et al, 2014;Oesterhus et al, 2016). Cardiovascular drugs are often involved in DDIs experienced by outpatients and inpatients (Straubhaar, Krähenbühl, & Schlienger, 2006).…”

Section: Discussionmentioning

confidence: 99%

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

Castilho

Reis

Borges

et al. 2017

Psychiatric Ment Health Nurs

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Introduction Despite the impact on patient safety and the fact that prevalence is higher in older patients, previous research did not analyse drug-drug interactions (DDIs) in view of nursing care of elderly psychiatric patients. Aim To identify potential drug-drug interactions and polypharmacy in prescriptions of aged inpatients with psychiatric disorders and analyse associated factors. Methods In this retrospective cross-sectional study, we analysed the medical records of institutionalized patients diagnosed with psychiatric disorders (n = 94), aged >60 years, and prescribed multiple medications. Drug prescriptions were checked at admission, midway through and the last prescription. Factors associated with DDI occurrence were assessed using multivariable logistic regression analysis. Results A DDI prevalence potential of 67.0%, 74.5% and 80.8% occurred in patients at admission, midway through hospitalization and the last prescription, respectively. Most of the prescribed drugs were nervous system agents. A high percentage of serious and contraindicated potential DDIs occurred. Age between 60 and 69 years, use of cardiovascular and respiratory system drugs, and the number of medications contributed significantly to DDI. Implications for mental health nursing Knowledge on the factors associated with DDIs in patients with mental disorders can contribute to the improvement of effectiveness and safety of nursing care.

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Severity and Management of Drug–Drug Interactions in Acute Geriatric Patients

Abstract: The present study shows that acute geriatric patients are frequently exposed to DDIs for which active management is recommended in order to avoid unfavorable clinical outcomes. The integration of pharmacists into interdisciplinary teams could prevent potentially severe DDIs in the elderly.

Cited by 23 publications

References 96 publications

Potential drug–drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

Potential drug–drug interactions among elderly patients admitted to medical ward of Ayder Referral Hospital, Northern Ethiopia: a cross sectional study

Interações medicamentosas em prescrições de idosos hipertensos: prevalência e significância clínica

Potential drug–drug interactions and polypharmacy in institutionalized elderly patients in a public hospital in Brazil

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