Sévérité de la dermatite atopique et taux de vitamine D : étude transversale

Ronceray, S.; Benkalfate, L.; Saillard, Colette; Ezzedine, Khaled; Adamski, H.; Dupuy, Alain; Droitcourt, Catherine

doi:10.1016/j.annder.2014.01.013

Cited by 6 publications

(1 citation statement)

References 42 publications

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“…As an example, the association between atopic dermatitis (AD) severity and vitamin deficiency is contradictory. Serum vitamin D concentrations were not significantly related to AD severity in different populations [59,60]. Vitamin D receptor polymorphism is associated with AD susceptibility [61][62].…”

Section: Vitamin D Metabolism and Skin Homeostasismentioning

confidence: 99%

A Review of the Role of Vitamins in Psoriasis in Pregnancy

Güngör¹

2016

Int. J. Gynecol. Obstet. & Neona. Care

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Psoriasis is an immune mediated chronic inflammatory disorder. Psoriasis treatment regimen is an immune regulation and inhibition of the cell cycle to prevent hyper proliferation of keratinocytes. Psoriasis does not affect the reproductive ability of patients; however, psoriatic women in reproductive period should be aware of the side effects of psoriatic medication. Understanding the molecular mechanisms beyond Psoriasis is crucial in developing effective treatment options for Psoriasis and preventing birth defects such as spontaneous abortions, intermittent fetal bradycardia, malformations and miscarriages. Vitamin A and vitamin D are the skin hormones that regulate the cell cycle of the keratinocytes. Vitamin A and D deliveries are extensively used in psoriasis treatment. Vitamin A is important for neuronal development; however, excessive use of vitamin A is teratogenic. Vitamin D is useful for Psoriasis treatment and is required for bone integrity. Vitamin D is also important for women's fertility. Both vitamin A and vitamin D play a pleiotropic role in metabolism by regulating different gene expressions. Thus, the use of the vitamins or their derivatives in psoriasis treatment is vital for the fetus development. In this review we focus on the vitamin A and D metabolism, particularly molecular and genetic aspects of psoriasis treatment during pregnancy.

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Section: Vitamin D Metabolism and Skin Homeostasismentioning

confidence: 99%

A Review of the Role of Vitamins in Psoriasis in Pregnancy

Güngör¹

2016

Int. J. Gynecol. Obstet. & Neona. Care

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Systemic Agents for Severe Atopic Dermatitis in Children

Notaro

Sidbury

2015

Pediatr Drugs

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Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial

Borzutzky,

Iturriaga,

Pérez‐Mateluna

et al. 2024

Acad Dermatol Venereol

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BackgroundVitamin D (VD) deficiency is common among patients with atopic dermatitis (AD) and often associated with severity. However, randomized trials of VD supplementation in AD have had equivocal results, and there is little information regarding the effect of VD supplementation on type 2 immunity in AD patients.ObjectivesTo investigate the efficacy of VD supplementation to decrease severity of AD and to alter type 2 immunity biomarkers.MethodsWe performed a randomized, double‐blind, placebo‐controlled trial. We randomly assigned 101 children with AD to weekly oral vitamin D3 (VD3) or placebo for 6 weeks. The primary outcome was the change in the Severity Scoring of AD (SCORAD).ResultsMean age of subjects was 6.3 ± 4.0 years, and baseline SCORAD was 32 ± 29. At baseline, 57% of children were VD deficient, with no difference between groups. Change in 25(OH)D was significantly greater with VD3 than placebo (+43.4 ± 34.5 nmol/L vs. +2.3 ± 21.2 nmol/L, p < 0.001). SCORAD change at 6 weeks was not different between VD and placebo (−5.3 ± 11.6 vs. −5.5 ± 9.9, p = 0.91). There were no significant between‐group differences in change of eosinophil counts, total IgE, Staphylococcal enterotoxin specific IgE, CCL17, CCL22, CCL27, LL‐37 or Staphylococcus aureus lesional skin colonization. Vitamin D receptor (VDR) gene single nucleotide polymorphisms FokI, ApaI and TaqI did not modify subjects' response to VD supplementation.ConclusionsAmong children with AD, weekly VD supplementation improved VD status but did not modify AD severity or type 2 immunity biomarkers compared to placebo (ClinicalTrials.gov NCT01996423).

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Sévérité de la dermatite atopique et taux de vitamine D : étude transversale

Cited by 6 publications

References 42 publications

A Review of the Role of Vitamins in Psoriasis in Pregnancy

A Review of the Role of Vitamins in Psoriasis in Pregnancy

Systemic Agents for Severe Atopic Dermatitis in Children

Effect of weekly vitamin D supplementation on the severity of atopic dermatitis and type 2 immunity biomarkers in children: A randomized controlled trial

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