Severe vitamin <scp>D</scp> deficiency is associated with non‐tuberculous mycobacterial lung disease: A case‐control study

Jeon, Kyeongman; Kim, Su Young; Jeong, Byeong‐Ho; Chang, Betty L.; Shin, Sung Jae; Koh, Won Jung

doi:10.1111/resp.12109

Cited by 34 publications

(33 citation statements)

References 36 publications

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“…Furthermore, the low incidence of NTM infections in warmer months could be linked to seasonal variations in vitamin D levels. Variations in vitamin D metabolism previously have been linked to NTM susceptibility (24,25). However, in our study, patients and healthy controls did not differ in sunlight exposure, and vitamin D supplementation in the first year of life occurred more often in the NTM-infected cohort than in controls.…”

Section: Discussioncontrasting

confidence: 65%

Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

Kuntz¹,

Kohlfürst²,

Feiterna‐Sperling³

et al. 2020

Emerg. Infect. Dis.

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Section: Discussioncontrasting

confidence: 65%

Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

Kuntz¹,

Kohlfürst²,

Feiterna‐Sperling³

et al. 2020

Emerg. Infect. Dis.

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“…Dendritic cells that present antigens to T cells are inhibited by 1,25-dihydroxyvitamin D in their differentiation and activation [19]. Based on this evidence, a large number of trials have examined the link between vitamin D and several infectious conditions such as acute viral respiratory tract infections, recurrent group A streptococcal tonsillopharyngitis, and tuberculosis [20,21,22]. …”

Section: Discussionmentioning

confidence: 99%

The Association between Vitamin D Levels and Urinary Tract Infection in Children

et al. 2015

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Aim: We aimed to examine whether there is any association between serum levels of 25-hydroxyvitamin D [25(OH)D₃] and urinary tract infection (UTI) among children. Methods: White blood cell count, serum C-reactive protein, calcium, phosphorus, alkaline phosphatase, parathormone, and serum 25(OH)D₃ levels were measured in 82 children experiencing a ﬁrst episode of UTI, with no risk factors for UTI, and 64 healthy control children. Results: The mean serum levels of 25(OH)D₃ among children with UTI were significantly lower than those of controls (11.7 ± 3.3 vs. 27.6 ± 4.7 ng/ml; p < 0.001). The serum levels of 25(OH)D₃ were significantly lower in patients with acute pyelonephritis compared to patients with lower UTI (8.6 ± 2.8 vs. 14.2 ± 3.0 ng/ml; p < 0.001). Within the study group, mean serum levels of 25(OH)D₃ among girls were lower than those of boys (10.9 ± 3.4 ng/ml vs. 13.2 ± 4.4 ng/ml; p < 0.001). Multivariate analysis showed that a serum 25(OH)D₃ level of <20 ng/ml (odds ratio 3.503, 95% confidence interval 1.621-7.571; p = 0.001) was associated with UTI in children. Conclusions: Our results suggest that vitamin D deficiency may be a risk factor for UTI in children.

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“…Vitamin D supplements reduce the risk of acute respiratory infection [6, 7]. Many observational studies have shown that vitamin D status is inversely associated with the prevalence of common colds [8–10].…”

Section: Introductionmentioning

confidence: 99%

Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice

Gui

Chen

et al. 2017

Virol J

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BackgroundH9N2 influenza viruses circulate globally and are considered to have pandemic potential. The hyper-inflammatory response elicited by these viruses is thought to contribute to disease severity. Calcitriol plays an important role in modulating the immune response to viral infections. However, its unknown whether calcitriol can attenuate the inflammatory response elicited by H9N2 influenza virus infection.MethodsHuman lung A549 epithelial cells were treated with calcitriol (100 nM) and then infected with an H9N2 influenza virus, or infected and then treated with calcitriol (30 nM). Culture supernatants were collected every 24 h post infection and the viral growth kinetics and inflammatory response were evaluated. Calcitriol (5 mg/kg) was administered daily by intraperitoneal injection to BABL/c mice for 15 days following H9N2 influenza virus infection. Mice were monitored for clinical signs of disease, lung pathology and inflammatory responses.ResultsCalcitriol treatment prior to and post infection with H9N2 influenza significantly decreased expression of the influenza M gene, IL-6, and IFN-β in A549 cells, but did not affect virus replication. In vivo, we found that calcitriol treatment significantly downregulated pulmonary inflammation in mice 2 days post-infection, but increased the inflammatory response 4 to 6 days post-infection. In contrast, the antiviral cytokine IFN-β was significantly higher in calcitriol-treated mice than in the untreated infected mice at 2 days post-infection, but lower than in untreated infected mice on days 4 and 8 post-infection. The elevated levels of pro-inflammatory cytokines and the decreased levels of antiviral cytokine are consistent with the period of maximum body weight loss and the lung damage in calcitriol-treated mice.ConclusionsThese results suggest that calcitriol treatment might have a negative impact on the innate immune response elicited by H9N2 infection in mice, especially at the later stage of influenza virus infection. This study will provide some novel insights into the use of calcitriol to modulate the inflammatory response elicited by influenza virus infection in humans.

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Severe vitamin D deficiency is associated with non‐tuberculous mycobacterial lung disease: A case‐control study

Abstract: Patients with NTM lung disease have a high prevalence of severe VDD and VDD was independently associated with NTM lung disease. Further studies are needed to examine causality.

Cited by 34 publications

References 36 publications

Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

Risk Factors for Complicated Lymphadenitis Caused by Nontuberculous Mycobacteria in Children

The Association between Vitamin D Levels and Urinary Tract Infection in Children

Effects of calcitriol (1, 25-dihydroxy-vitamin D3) on the inflammatory response induced by H9N2 influenza virus infection in human lung A549 epithelial cells and in mice

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