Severe vitamin D deficiency among pregnant women and their newborns in Turkey

Parlak, Mesut; Kalay, Salih; Kalay, Zuhal; Kireçci, Ahmet; Guney, Ozgur; Köklü, Esad

doi:10.3109/14767058.2014.924103

Cited by 45 publications

(30 citation statements)

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“…Vitamin D insufficiency in women of childbearing years is well-documented (40-44). The intent of reporting the preliminary findings of this pilot study is to demonstrate an approach to investigate maternal vitamin D status during pregnancy that likely impacts biological mechanisms e.g.…”

Section: Discussionmentioning

confidence: 99%

Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: A pilot study

Reed

Voronca

Wingate

et al. 2017

Pediatric Dental Journal

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Background Enamel hypoplasia (EH) increases risk for dental caries and also is associated with vitamin D deficiencies. This pilot study evaluates the feasibility to determine the association of human maternal circulating vitamin D concentrations during pregnancy and EH in infant’s teeth that develop in utero. Methods A pilot population of 37 children whose mothers participated in a RCT of vitamin D supplementation during pregnancy was evaluated. Major outcome was EH and major exposure was maternal monthly serum circulating 25(OH)D concentrations during pregnancy. EH was assessed using the Enamel Defect Index and digital images made by a ProScope High Resolution™ handheld digital USB microscope at 50x magnification. Results During initial 8 weeks of study, 29/37 children had evaluable data with mean age of 3.6 ± 0.9 years; 48% male; and 45% White, 31% Hispanic, and 24% Black. EH was identified in 13 (45%) of the children. Maternal mean 25(OH)D concentrations were generally lower for those children with EH. Conclusions Preliminary results suggest follow-up of children of mothers in a vitamin D supplementation RCT during pregnancy provides an important approach to study the etiology of EH in the primary teeth. Further study is needed to discern thresholds and timing of maternal serum 25(OH)D concentrations during pregnancy associated with absence of EH in teeth that develop in utero. Potential dental public health implications for prevention of early childhood caries via sound tooth structure as related to maternal vitamin D sufficiency during pregnancy need to be determined.

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Section: Discussionmentioning

confidence: 99%

Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: A pilot study

Reed

Voronca

Wingate

et al. 2017

Pediatric Dental Journal

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“…The most optimal course of pregnancy was observed among the patients taking vitamin D and Ca from the period of pregravid preparation and during pregnancy, the complications of the pregnancy course were more often recorded among the women who had not undergone pregravid preparation. Among the patients who used vitamin D and Ca during pregravid preparation and during pregnancy, the premature detachment of the normally located placenta (PDNLP) was observed 3 times less frequently, the placental changes in the form of its volume decrease or increase were 3 times less often, the syndrome of fetus delayed development was 3.6 times less often (Table 3) (González and Villalobos-Antúnez, 2016;Parlak et al, 2015). Table-3.…”

Section: Resultsmentioning

confidence: 99%

Borrowings in the Lexical-Semantic System of the Russian Literary Language

2018

TJSSR

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Despite some success in the study of pre-eclampsia, it is still one of the main causes in the structure of maternal mortality. The tissues of the reproductive organs: ovaries, uterus, placenta, testis and pituitary have the receptors for vitamin D, and the association of vitamin D role with reproductive health is evident. The aim of the study was to study the effect of vitamin D deficiency on renin concentration among pregnant women from the groups of preeclampsia development risk. The pregnant women with pre-eclampsia and the patients with a high risk of preeclampsia development who are planning pregnancy were studied for vitamin D, endothelin and renin concentrations, since it is known from literature data that enzymes like renin are found in the uterus, placenta and in the walls of some large arteries. The material of the study was blood. The method of enzyme immunoassay and the sets of biomedicagruppe (Germany) were used to determine the availability of vitamin D, the enzyme immunoassay and Immuno Chem (USA) sets were used to determine the renin concentration. The patients with developed preeclampsia showed highly reliable correlations between low vitamin D values and high blood pressure (r = 0.68, p < 0.01), high endothelin level in blood (r = 0.56, p < 0.01), high renin concentration (r = 0.72, p < 0.01), an early onset of PE (r = 0.46 p < 0.05). The risk group of pre-eclampsia development among the women planning a pregnancy was composed of 30 women with hypertension, 31 -with kidney disease, 24 -with obesity (BMI > 34), 13 -with body weight deficit. The supply of vitamin D and the level of ionized Ca among these women were significantly lower (0.07 ± 0.01 mmol/l) than among the women not included in risk group (1.2 ± 0.02 mmol/l); the renin concentration exceeded the mean values among the women of the control group. The patients with hypertension and obesity had the renin concentration at the upper limit of physiological parameters (30.4 ± 1.8 and 28.4 ± 1.6 pg/ml, respectively), and the level of vitamin D was lower than in other nosologies among the patients of high risk group (14.8 ± 1.5 and 13.9 ± 1.5 ng/ml, respectively). At renal diseases and body mass deficiency, the renin concentration was 16.6 ± 0.7 and 12.4 ± 0.8 pg/ml, respectively, while the level of vitamin D was 17.4 ± 1.5 and 16.9 ± 1.2 ng/ml.

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“…В исследо-ваниях последних лет отмечено, что снижение концен-трации витамина D -потенциальный значимый фактор риска для таких заболеваний, как рак, сердечно-сосуди-стые заболевания [31][32][33], сахарный диабет [34][35][36], артериальная гипертензия [37][38][39], аутоиммунные заболевания [40][41][42], нарушения обмена веществ [43,44], инфекционные заболевания, вызванные снижени-ем иммунитета [45], и некоторые психоневрологиче-ские расстройства [46]. Дефицит витамина D увеличива-ет частоту преждевременных родов, снижение веса при рождении и гипертонической болезни во время бере-менности [47][48][49][50][51][52]. Авторы полагают, что эти состояния могут возникать в результате недостаточного влияния витамина D на иммуносупрессию или плацентарное развитие у пациенток с дефицитом витамина D [53].…”

Section: рисунок 2 эффекты витамина Dunclassified

Global vitamin D status problems: causes, pathogenetic mechanisms, treatment, prevention measures

2018

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There is a need to improve the status of vitamin D. Vitamin D not only affects the processes of formation of the musculoskeletal system, but also actively participates in many extra-osseous effects of cholecalciferol. Modern publications point to a number of positive effects of vitamin D for people of all ages. The modern vitamin D3 preparation Detrimax is recommended as an active food additive (tablet form containing 1000 IU of vitamin D3 (cholecalciferol)) and corresponds to the most frequent daily requirement for vitamin D3. Prophylaxis of vitamin D deficiency should be a priority in health policy.

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Severe vitamin D deficiency among pregnant women and their newborns in Turkey

Cited by 45 publications

References 15 publications

Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: A pilot study

Prenatal vitamin D and enamel hypoplasia in human primary maxillary central incisors: A pilot study

Borrowings in the Lexical-Semantic System of the Russian Literary Language

Global vitamin D status problems: causes, pathogenetic mechanisms, treatment, prevention measures

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