Severe veno‐occlusive disease in an overweight infant with a renal tumor

Faqih, Nesreen; Hazin, Ribhi; Barbar, Maha; Ismael, Taleb; Al-Gharabli, Feda; Sultan, Iyad

doi:10.1002/pbc.21944

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2011

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“…Ludwig et al 11 reported a mortality of 8.7% with two deaths out of 23 cases. Otherwise, fatal cases including an adult patient with Wilms tumor, are rarely reported 10,13-15.…”

Section: Discussionmentioning

confidence: 99%

Dactinomycin-induced Hepatic Sinusoidal Obstruction Syndrome Responding to Treatment with N-acetylcysteine

Lee¹,

P²

2011

J. Cancer

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Hepatic sinusoidal obstruction syndrome is commonly described in pediatric oncology as a complication of chemotherapy. It has also been occasionally reported in adult cancer patients. Treatment is largely supportive with fluid restriction. A 16-month-old girl with stage II Wilms tumor receiving post-nephrectomy chemotherapy with dactinomycin and vincristine developed hepatic sinusoidal obstruction syndrome with painful hepatomegaly, ascites with significant weight gain, grossly deranged liver function, severe thrombocytopenia, and reversal of blood flow in the portal vein on Doppler sonography. Treatment with N-acetylcysteine was followed by complete resolution of clinical signs and amelioration of laboratory abnormalities within 72 hours of treatment. N-acetylcysteine is a safe and probably an effective treatment for dactinomycin-induced hepatic sinusoidal obstructive syndrome.

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“…Ludwig et al 11 reported a mortality of 8.7% with two deaths out of 23 cases. Otherwise, fatal cases including an adult patient with Wilms tumor, are rarely reported 10,13-15.…”

Section: Discussionmentioning

confidence: 99%

Dactinomycin-induced Hepatic Sinusoidal Obstruction Syndrome Responding to Treatment with N-acetylcysteine

Lee¹,

P²

2011

J. Cancer

View full text Add to dashboard Cite

show abstract

Severe veno‐occlusive disease in an overweight infant with a renal tumor

Cited by 1 publication

References 6 publications

Dactinomycin-induced Hepatic Sinusoidal Obstruction Syndrome Responding to Treatment with N-acetylcysteine

Dactinomycin-induced Hepatic Sinusoidal Obstruction Syndrome Responding to Treatment with N-acetylcysteine

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