Severe traumatic brain injury (TBI) – a seven-year comparative study in a Department of Forensic Medicine

Ţolescu, Răzvan Ştefan; Zorilă, Marian Valentin; Serbănescu, M; Kamal, Kamal Constantin; Zorilă, George Lucian; Dumitru, Ilie; Florou, Charoula; Mogoantă, Laurențiu; Văduva, Ion Alexandru; Stanca, Liliana; Zăvoi, Roxana Eugenia

doi:10.47162/rjme.61.1.10

Cited by 4 publications

(1 citation statement)

References 57 publications

(66 reference statements)

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“…Our study shows that brain changes in the case of severe TBI are complex, which requires special therapeutic measures to save the patient's life and recovery after neurological sequelae. Most of the studies in recent years showed the severity and complexity of TBI [73][74][75][76] and the need to continue investigations to identify the biological markers that can offer information on the severity of neurological lesions and the efficiency of therapeutic measures.…”

Section: Figure 6 -Ihc Changes In Cerebral Parenchyma In Patients Dec...mentioning

confidence: 99%

Histological and immunohistochemical study of brain damage in traumatic brain injuries in children, depending on the survival period

Ţolescu

Zorilă²,

Kamal³

et al. 2022

Rom J Morphol Embryol

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Numerous studies showed that, at present, traumatic brain injury (TBI) is one of the main causes of death in young adults, but also a main cause of disabilities at all ages. For these reasons, TBI are continuously investigated. In our study, we evaluated the histopathological (HP) and immunohistochemical (IHC) changes that occurred in the brain in underage patients after a severe TBI depending on the survival period. We histopathologically and immunohistochemically analyzed a number of 22 cases of children, deceased in Dolj County, Romania, following some severe TBI, undergoing autopsy within the Institute of Forensic Medicine in Craiova between 2015-2020. Patients were divided into three groups depending on the survival period, namely: (i) patients who died during the first 24 hours of the accident; (ii) patients who died after seven days of survival; (iii) patients who died after 15 days of survival. Microscopic examinations of the brain fragments, collected during the necropsy examination, showed that the traumatic agent caused primary injuries in all brain structures (cerebral parenchyma, meninges, blood vessels). However, HP injuries ranged in size and intensity from one area to another of the brain. In patients with a longer survival period, there was observed the presence of smaller primary injuries and larger secondary injuries. There was also observed a growth in the number of meningo-cerebral microscopic injuries, depending on the increase of the survival period.

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Section: Figure 6 -Ihc Changes In Cerebral Parenchyma In Patients Dec...mentioning

confidence: 99%

Histological and immunohistochemical study of brain damage in traumatic brain injuries in children, depending on the survival period

Ţolescu

Zorilă²,

Kamal³

et al. 2022

Rom J Morphol Embryol

Self Cite

View full text Add to dashboard Cite

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Forensic neuropathology in the past decade: a scoping literature review

Oura

Hakkarainen

Sajantila

2023

Forensic Sci Med Pathol

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While there has been notable research activity in the field of clinical neuropathology over the recent years, forensic approaches have been less frequent. This scoping literature review explored original research on forensic neuropathology over the past decade (January 1, 2010, until February 12, 2022) using the MEDLINE database. The aims were to (1) analyze the volume of research on the topic, (2) describe meta-level attributes and sample characteristics, and (3) summarize key research themes and methods. Of 5053 initial hits, 2864 fell within the target timeframe, and 122 were included in the review. Only 3–17 articles were published per year globally. Most articles originated from the Europe (39.3%) and Asia (36.1%) and were published in forensic journals (57.4%). A median sample included 57 subjects aged between 16 and 80 years. The most common research theme was traumatic intracranial injury (24.6%), followed by anatomy (12.3%) and substance abuse (11.5%). Key methods included immunotechniques (31.1%) and macroscopic observation (21.3%). Although a number of novel findings were reported, most were of preliminary nature and will require further validation. In order to reach breakthroughs and validate novel tools for routine use, more research input is urged from researchers across the world. It would be necessary to ensure appropriate sample sizes and make use of control groups.

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Centella asiatica effect on traumatic brain injury: A systematic review

Rosyidi,

Rusidi,

Januarman

et al. 2024

Surgical Neurology International

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Background: Mortality and morbidity in traumatic brain injury (TBI) cases remain a global problem. Various therapeutic modalities have been researched, including using herbal medicine. Centella asiatica has a lot of potential in neuropharmacology for various diseases. This systematic review aims to comprehensively review the currently available data about the impact of C. asiatica on TBI in a rat model. Methods: Systematic searches were conducted on PubMed, Scopus, and Google Scholar up to July 2023. This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. Researchers screened the titles and abstracts of all identified studies and then selected relevant studies through full-text reviews. Studies reported the effect of C. asiatica on animal model of TBI were included in the study. Data were extracted, and the result was reported using descriptive analysis. The risk of bias was evaluated using SYRCLE. Results: Four studies met the inclusion criteria. One study highlighted the potential neuroprotective effects of Asiatic acid, one study explored spade leaf extract phytosome, while the rest used C. asiatica extracts. The primary findings of the included research revealed that C. asiatica might reduce oxidative stress, decrease neuronal apoptosis, have anti-inflammatory properties, alleviate neurological dysfunction, reduce cerebral edema, and boost cognitive performance in the TBI-induced rat’s model. Conclusion: This review suggests that C. asiatica had the potential to benefit the TBI-induced rat model in terms of decreasing morbidity. Nevertheless, more studies are needed to perform a meta-analysis and ascertain the effects of C. asiatica on TBI in animal models.

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Severe traumatic brain injury (TBI) – a seven-year comparative study in a Department of Forensic Medicine

Cited by 4 publications

References 57 publications

Histological and immunohistochemical study of brain damage in traumatic brain injuries in children, depending on the survival period

Histological and immunohistochemical study of brain damage in traumatic brain injuries in children, depending on the survival period

Forensic neuropathology in the past decade: a scoping literature review

Centella asiatica effect on traumatic brain injury: A systematic review

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