Severe Trauma to the Liver With “Hepatorenal Syndrome”

McCorkle, H.J.; Howard, Frederick S.

doi:10.1097/00000658-194208000-00007

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…From the 1920s up to the 1950s, the abdominal surgeon James Gordon Heyd described this clinical phenomenon thoroughly, which has thus also been referred to as Flint’s syndrome or Heyd’s syndrome, respectively [24,25]. During the past century, the term ‘hepatorenal syndrome’ has undergone several and often drastic redefinitions and reclassifications while the understanding of the underlying pathophysiology was improving.…”

Section: Association Between the Liver And The Kidney From A Historicmentioning

confidence: 99%

“…The association of fulminant renal failure with diseases of the liver and the biliary tract is known for more than a century and has already been reported, in 1863 by Austin Flint, in a case series of patients with cirrhosis and ascites [ 23 ]. From the 1920s up to the 1950s, the abdominal surgeon James Gordon Heyd described this clinical phenomenon thoroughly, which has thus also been referred to as Flint’s syndrome or Heyd’s syndrome, respectively [ 24 , 25 ]. During the past century, the term ‘hepatorenal syndrome’ has undergone several and often drastic redefinitions and reclassifications while the understanding of the underlying pathophysiology was improving.…”

Section: Association Between the Liver And The Kidney From A Historicmentioning

confidence: 99%

“…He suspected endotoxin-induced vasospasm and ischemia as the pathophysiologic mechanism [ 29 ]. During the following decades, the ‘hepatorenal syndrome’ became increasingly recognized as its own entity as an own entity of renal failure in patients with cirrhosis characterized by fulminant progression and high mortality [ 24 , 25 , 30–33 ].…”

Section: Association Between the Liver And The Kidney From A Historicmentioning

confidence: 99%

See 2 more Smart Citations

Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome

Bucsics

Krones

2017

Gastroenterology Report

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Renal dysfunction is a common complication of liver cirrhosis and of utmost clinical and prognostic relevance. Patients with cirrhosis are more prone to developing acute kidney injury (AKI) than the non-cirrhotic population. Pre-renal AKI, the hepatorenal syndrome type of AKI (HRS-AKI, formerly known as ‘type 1’) and acute tubular necrosis represent the most common causes of AKI in cirrhosis. Correct differentiation is imperative, as treatment differs substantially. While pre-renal AKI usually responds well to plasma volume expansion, HRS-AKI and ATN require different specific approaches and are associated with substantial mortality. Several paradigms, such as the threshold of 2.5 mg/dL for diagnosis of HRS-AKI, have recently been abolished and novel urinary biomarkers are being investigated in order to facilitate early and correct diagnosis and treatment of HRS-AKI and other forms of AKI in patients with cirrhosis. This review summarizes the current diagnostic criteria, as well as pathophysiologic and therapeutic concepts for AKI and HRS-AKI in cirrhosis.

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Section: Association Between the Liver And The Kidney From A Historicmentioning

confidence: 99%

Section: Association Between the Liver And The Kidney From A Historicmentioning

confidence: 99%