Severe tracheobronchial stenosis in a patient with Crohn′s disease

Kuźniar, Tomasz J.; Sleiman, C; Brugière, Olivier; Groussard, O; Mal, Hervé; Mellot, François; Parienté, R; Małolepszy, J; Fournier, Marie

doi:10.1034/j.1399-3003.2000.15a38.x

Cited by 37 publications

(39 citation statements)

References 26 publications

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“…However, pulmonary lesions have been reported in patients with Crohn's disease, such as unexplained chronic bronchitis, bronchiolitis obliterans with organizing pneumonia, pleuropericarditis (1), recurrent pulmonary edema (3), granulomatous (4,5) and nongranulomatous interstitial pulmonary disease (6), granulomatous lung masses (7), bronchiectasis (8), and granulomatous bronchiolitis (9). Tracheal involvement in Crohn's disease is even more unusual and consists of mucosal inflammation (10)(11)(12). Drug therapy is another complicating factor, since sulfasalazine used in the treatment of Crohn's disease can also cause reactions in the lung (13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease

Bártholo

Zaltman

Elia

et al. 2005

Braz J Med Biol Res

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With the aim of investigating the presence of latent inflammatory process in the lungs of patients with Crohn's disease, 15 patients with Crohn's disease were evaluated by spirometry, the methacholine challenge test, induced sputum, and skin tests for inhaled antigens. Serum IgE, erythrocyte sedimentation rate and hematocrit were also determined. The patients were compared with 20 healthy controls by the Mann-Whitney and Fisher exact tests. Their respiratory physical examination was normal. None had a personal or family history of clinical atopy. None had a previous history of pulmonary disease, smoking or toxic bronchopulmonary exposure. None had sinusitis, migraine, diabetes mellitus, or cardiac failure. Four (26.6%) of the patients with Crohn's disease had a positive methacholine challenge test whereas none of the 20 controls had a positive methacholine test (P = 0.026, Fisher exact test). Patients with Crohn's disease had a higher level of lymphocytes in induced sputum than controls (mean 14.59%, range 3.2-50 vs 5.46%, 0-26.92%, respectively; P = 0.011, Mann-Whitney test). Patients with Crohn's disease and a positive methacholine challenge test had an even higher percentage of lymphocytes in induced sputum compared with patients with Crohn's disease and a negative methacholine test (mean 24.88%, range 12.87-50 vs 10.48%, 3.2-21.69%; P = 0.047, Mann-Whitney test). The simultaneous findings of bronchopulmonary lymphocytosis and bronchial hyperresponsiveness in patients with Crohn's disease were not reported up to now. These results suggest that patients with Crohn's disease present a subclinical inflammatory process despite the absence of pulmonary symptoms.

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Section: Introductionmentioning

confidence: 99%

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease

Bártholo

Zaltman

Elia

et al. 2005

Braz J Med Biol Res

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“…Endoscopic studies revealed polypoid or pseudotumoural structures and/or circumferential inflammation obstructing the airway lumen. These lesions were friable and haemorrhagic [16,43,[47][48][49]. Histological examination showed granulation tissue and mixed inflammation with domination of lymphocytes and plasma cells [43,[47][48][49].…”

Section: Airways Diseases -Larynx Trachea Bronchi Bronchiolimentioning

confidence: 99%

“…It may occur at any level from the larynx to the segmental bronchi [16,43,[47][48][49]. Clinical presentation in these cases included dyspnoea, fever, expectoration, stridor and/or wheeze [16,43,[47][48][49].…”

Section: Airways Diseases -Larynx Trachea Bronchi Bronchiolimentioning

confidence: 99%

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Respiratory System Involvement in Inflammatory Bowel Diseases

Kacprzak¹,

Szturmowicz²,

Kuś³

2017

Advances in Respiratory Medicine

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“…UAD may present with hoarseness, stridor and severe respiratory distress or just with cough, phlegm and shortness of breath [43,44] . Physical examination may reveal wheezing during inspiration, expiration or both.…”

Section: Upper Airwaysmentioning

confidence: 99%

Patterns of airway involvement in inflammatory bowel diseases

Papanikolaou

Kagouridis

Papiris

2014

WJGP

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Extraintestinal manifestations occur commonly in inflammatory bowel diseases (IBD). Pulmonary manifestations (PM) of IBD may be divided in airway disorders, interstitial lung disorders, serositis, pulmonary vasculitis, necrobiotic nodules, drug-induced lung disease, thromboembolic lung disease and enteropulmonary fistulas. Pulmonary involvement may often be asymptomatic and detected solely on the basis of abnormal screening tests. The common embryonic origin of the intestine and the lungs from the primitive foregut, the co-existence of mucosa associated lymphoid tissue in both organs, autoimmunity, smoking and bacterial translocation from the colon to the lungs may all be involved in the pathogenesis of PM in IBD. PM are mainly detected by pulmonary function tests and highresolution computed tomography. This review will focus on the involvement of the airways in the context of IBD, especially stenoses of the large airways, tracheobronchitis, bronchiectasis, bronchitis, mucoid impaction, bronchial granulomas, bronchiolitis, bronchiolitis obliterans syndrome and the co-existence of IBD with asthma, chronic obstructive pulmonary disease, sarcoidosis and a1-antitrypsin deficiency.© 2014 Baishideng Publishing Group Inc. All rights reserved. Key words: Inflammatory bowel diseases; Airways; BronchiolitisCore tip: The lung is commonly involved in inflammatory bowel diseases; however, airway involvement is often overlooked. This review will help gastroenterologists recognize the involvement of the airways in the context of inflammatory bowel diseases (IBD), especially stenoses of the large airways, tracheobronchitis, bronchiectasis, bronchitis, mucoid impaction, bronchial granulomas, bronchiolitis, bronchiolitis obliterans syndrome and the co-existence of IBD with asthma, chronic obstructive pulmonary disease, sarcoidosis and a1-antitrypsin deficiency, and appropriately manage their patients.Papanikolaou I, Kagouridis K, Papiris SA. Patterns of airway involvement in inflammatory bowel diseases. World J Gastrointest Pathophysiol

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Severe tracheobronchial stenosis in a patient with Crohn′s disease

Cited by 37 publications

References 26 publications

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease

Bronchial hyperresponsiveness and analysis of induced sputum cells in Crohn's disease

Respiratory System Involvement in Inflammatory Bowel Diseases

Patterns of airway involvement in inflammatory bowel diseases

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